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Browsing by Author "Smith, Peter"

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A Review of Psychotropic drug prescription for patients with Intellectual disability at Alexandra Hospital (a specialist Intellectual Disability psychiatric hospital) outpatient clinic

Author: Akpabio, Idorenyin Ubon Date: 2021 Background: People with intellectual disability are more likely than the general population to be prescribed psychotropic agents. The most common indications include treatment of a psychiatric disorder and management of behaviours that ... Read more
The antimalarial potential of Ugandan traditional medicines : a study of six plants used to treat malaria symptoms

Author: Waako, Paul Date: 2003 The study investigates the antimalarial potential of six Ugandan traditional medicinal plants Senecfo discifolius oliv, Senecio stuhlmannii, Indigofera emarginella steud. Ex A. Rich, Aspifia africana (Pers) C.D. Adams, Cardiospermum halicacabum ... Read more
Artesunate and amodiaquine : tolerability and drug interaction study in healthy normal volunteers

Author: Orrell, Catherine Date: 2005 Includes bibliographical references. Read more
Association of lopinavir concentrations with plasma lipid or glucose concentrations in HIV-infected South Africans: a cross sectional study

Author: Sinxadi, Phumla ; McIlleron, Helen ; Dave, Joel ; Smith, Peter ; Levitt, Naomi ; Maartens, Gary Date: 2012 BACKGROUND: Dyslipidaemia and dysglycaemia have been associated with exposure to ritonavir-boosted protease inhibitors. Lopinavir/ritonavir, the most commonly used protease inhibitor in resource-limited settings, often causes dyslipidaemia. ... Read more c b
Characterisation of Mefloquine accumulation in Plasmodium falciparum

Author: Walden, Jason C Date: 2003 Meﬂoquine has been in use for over twenty years and still very little is known about its interaction with Plasmodium falciparum. In 1979, Fitch er al carried out the only other published extensive investigation of meﬂoquine accumulation, but ... Read more
Complementary and alternate medicines: a forensic analysis of the potential adulteration of over-the-counter anorectics and "lifestyle" medicines in South Africa

Author: Catterson, Sandra Lynne Date: 2017 Background: Complementary and Alternate Medicines (CAMs) in South Africa are not yet subjected to the same rigorous testing required for allopathic (prescription) medication, yet they are freely available as over-the-counter medicines. Past ... Read more
The correlation between raised liver enzyme levels and high concentrations of rifampicin and its metabolites : 25-desacetyl rifampicin and 3-formyl rifampicin

Author: Reuter, Galya Dominique Date: 2001 Bibliography: leaves [98]-109. Read more
Curcumin-related hybrid compounds as potential antimalarial agents : design, synthesis, mechanistic investigations, biological evaluation and pharmacokinetic studies

Author: Guantai, Eric Date: 2010 Malaria remains one of the most devastating tropical diseases, with staggering infection and mortality statistics. Over 200 million clinical cases of malaria (resulting in 1 - 3 million deaths) are reported annually. Africa bears the greatest ... Read more
Determination of biomarkers for toxicity and antiretroviral adherence in hair in South African patients

Author: Johnston, Jenna Date: 2018 Background: Substance abuse is one of the many factors associated with poor levels of antiretroviral adherence and is also prevalent among HIV-infected individuals. Ethyl glucuronide, a minor metabolite of alcohol, is a stable biomarker in ... Read more
Determination of the effect of blood testing intervals on bioavailability and bioequivalence assessment of fixed-dose drug combination anti-tuberculosis drugs

Author: Gabriels, Gary Anthony Date: 2003 Includes bibliographical references. Read more
Development and partial validation of a method for the quantification of benzodiazepines and antidepressants in whole blood, serum and urine by liquid chromotography - Tandem mass spectrometry

Author: Pieters, Janke Date: 2015 The aim of this project is to develop a single quantification method for certain benzodiazepines, opiates and antidepressants in whole blood, serum and urine by LC-MS/M5 and to consequently validate the analytical method for official use in ... Read more
Development of a method for the screening and quantification of methamphetamine, and its major metabolite amphetamine, in hair using liquid chromatography-tandem mass spectrometry

Author: Johnston, Jenna Date: 2015 Hair has, over recent years, become widely recognised as an alternate or complementary matrix to blood and urine for drug analysis. Hair analysis offers a wider detection window after drug exposure than blood or urine testing and can provide ... Read more
The development, implementation and validation of a plasma-based high performance liquid chromatographic assay for Isoniazid and N-Acetylisoniazid: an acetylator status population study at Brewelskloof Hospital

Author: Cockcroft, Jennifer Jean Date: 2001 A novel high performance liquid chromatographic assay has been developed for the simultaneous determination of isoniazid and N-acetylisoniazid in plasma. Solid phase extraction involving C18 columns is used to extract the drug and the metabolite ... Read more
Disruption of maternal gut microbiota during gestation alters offspring microbiota and immunity

Author: Nyangahu, Donald D ; Lennard, Katie S ; Brown, Bryan P ; Darby, Matthew G ; Wendoh, Jerome M ; Havyarimana, Enock ; Smith, Peter ; Butcher, James ; Stintzi, Alain ; Mulder, Nicola ; Horsnell, William ; Jaspan, Heather B Date: 07 Jul 2018 Background: Early life microbiota is an important determinant of immune and metabolic development and may have lasting consequences. The maternal gut microbiota during pregnancy or breastfeeding is important for defining infant gut microbiota. ... Read more
Effects of amodiaquine and artesunate on sulphadoxine-pyrimethamine pharmacokinetic parameters in children under five in Mali

Author: Tekete, Mamadou ; Toure, Sekou ; Fredericks, Alfia ; Beavogui, Abdoul ; Sangare, Cheick ; Evans, Alicia ; Smith, Peter ; Maiga, Hamma ; Traore, Zoumana ; Doumbo, Ogobara ; Barnes, Karen ; Djimde, Abdoulaye Date: 2011 BACKGROUND:Sulphadoxine-pyrimethamine, in combination with artesunate or amodiaquine, is recommended for the treatment of uncomplicated malaria and is being evaluated for intermittent preventive treatment. Yet, limited data is available on ... Read more c b
Fast in vitro methods to determine the speed of action and the stage-specificity of anti-malarials in Plasmodium falciparum

Author: Le Manach, Claire ; Scheurer, Christian ; Sax, Sibylle ; Schleiferbock, Sarah ; Cabrera, Diego ; Younis, Yassir ; Paquet, Tanya ; Street, Leslie ; Smith, Peter ; Ding, Xavier ; Waterson, David ; Witty, Michael ; Leroy, Didier ; Chibale, Kelly ; Wittlin, Sergio Date: 2013 BACKGROUND: Recent whole cell in vitro screening campaigns identified thousands of compounds that are active against asexual blood stages of Plasmodium falciparum at submicromolar concentrations. These hits have been made available to the ... Read more c b
In vitro anti-plasmodial activity of Dicoma anomala subsp. gerrardii (Asteraceae): identification of its main active constituent, structure-activity relationship studies and gene expression profiling

Author: Becker, John ; van der Merwe, Marina ; van Brummelen, Anna ; Pillay, Pamisha ; Crampton, Bridget ; Mmutlane, Edwin ; Parkinson, Chris ; van Heerden, Fanie ; Crouch, Neil ; Smith, Peter ; Mancama, Dalu ; Maharaj, Vinesh Date: 2011 BACKGROUND: Anti-malarial drug resistance threatens to undermine efforts to eliminate this deadly disease. The resulting omnipresent requirement for drugs with novel modes of action prompted a national consortium initiative to discover new ... Read more c b
Integration of In Silico and In Vitro ADMET properties in lead identification and optimization of compounds for the treatment of parasitic diseases

Author: Thelingwani, Roslyn Date: 2012 Parasitic infections are the major causes of illness and death in tropical regions especially in Africa. The main parasitic diseases include leishmaniasis, filariasis, malaria, river blindness, Chagas disease and schistosomiasis. With the ... Read more
The investigation and assessment of Nutritional and Traditional Supplement products for content validity, contamination and adulteration

Author: Gabriels, Gary Anthony Date: 2013 Nutritional supplements are used by competitive and recreational athletes of all ages. As a consequence the supplement industry has grown to meet the increasing demand. The regulation of the supplement industry is unrefined, which increases ... Read more
An investigation of tetrahydrocannabinol, cannabidiol and cannabinol content of cannabis confiscated by the South African Police Service's Forensic Laboratories from various regions of South Africa

Author: Londt, Rolanda Sabrina Date: 2014 Includes abstract. Includes bibliographical references. Read more

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