Browsing by Author "Sinxadi, Phumla Z"

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Association of lopinavir concentrations with plasma lipid or glucose concentrations in HIV-infected South Africans: a cross sectional study

Author: Sinxadi, Phumla Z ; McIlleron, Helen M ; Dave, Joel A ; Smith, Peter J ; Levitt, Naomi S ; Maartens, Gary Date: 26 Oct 2012 Abstract Background Dyslipidaemia and dysglycaemia have been associated with exposure to ritonavir-boosted protease inhibitors. Lopinavir/ritonavir, the most commonly used protease inhibitor ... Read more c b
Efavirenz pharmacogenetics and metabolic toxicity in black South Africans

Author: Makgai, Lesiba Meshack Date: 2022 Background: Efavirenz is associated with hepatotoxicity, dyslipidaemia and dysglycaemia. We aimed to determine if CYP2B6 composite metaboliser genotypes influence lipids, glucose and ALT concentrations. Methods: Data and DNA from South African ... Read more
Pharmacogenomics and pharmacokinetics of antiretroviral drugs and their associations with metabolic complications in HIV-infected Black South Africans

Author: Sinxadi, Phumla Z Date: 2016 BACKGROUND: Antiretroviral therapy (ART), notably efavirenz and lopinavir, have been associated with metabolic abnormalities known to increase cardiovascular risk. Efavirenz and lopinavir pharmacokinetics demonstrate considerable interindividual ... Read more

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