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Browsing by Author "September, Alison"

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A pilot study to identify links between genetic variation and shoulder pain and dysfunction after breast cancer radiotherapy

Author: McLarty, Callum Date: 2021 Introduction – Treatment for breast cancer is associated with a risk of chronic shoulder and upper limb morbidity in up to 30% of patients. There is currently no consensus for the possible reason for this often repeated finding in the literature. ... Read more
Extracellular matrix gene sequence variant analyses and Achilles tendinopathy

Author: Saunders, Colleen Jayne Date: 2013 The primary aim of this thesis was to identify additional genetic elements predisposing individuals to risk of AT using a candidate gene, case-control genetic association approach, and to propose the biological mechanisms underlying this ... Read more
An investigation of DNA sequence variants in genes that regulate collagen fibrillogenesis and predisposition to musculoskeletal soft tissue injuries

Author: Hay, Melanie Date: 2013 The aim of this dissertation was to use a case-control genetic study to investigate the association of polymorphisms within the COL5A1, MIR608, COL11A1 and COL11A2, genes with AT and/or ACL injuries in Caucasian populations. These aims were ... Read more
The molecular investigation of Stargardt disease in South Africa

Author: September, Alison Date: 2003 Hereditary macular degeneration describes a group of conditions causing macular pathology. Stargardt disease (STGD) is the most common inherited juvenile macular dystrophy characterised by severed reduction of central visual acuity and normal ... Read more
A pathway-based approach investigating DNA sequence variants to implicate the inflammatory pathway in the predisposition to Achilles tendinopathy

Author: Nell, Erica-Mari Date: 2011 The aims of this dissertation were therefore (i) to follow a pathway-based approach investigating genes encoding proteins involved in the ECM degradation and apoptosis signalling cascade for associations with AT and (ii) to identify a polygenic ... Read more
Proteoglycan genes and anterior cruciate ligament injury susceptibility

Author: Mannion, Sasha Date: 2013 Genetic variants within genes involved in fibrillogenesis, including a polymorphism in the COL5A1 gene, have previously been associated with anterior cruciate ligament (ACL) injury susceptibility, specifically in females. Proteoglycans have ... Read more
Reliability of a Robotic Knee Testing Tool to Assess Rotational Stability of the Knee Joint in Healthy Female and Male Volunteers

Author: Beckley, Samantha ; Stinton, Shaun ; Lesosky, Maia ; September, Alison ; Collins, Malcolm ; Branch, Thomas ; Posthumus, Mike Date: 03 Aug 2020 Abstract Background Several clinical tests exist to assess knee laxity. Although these assessments are the predominant tools of diagnosis, they are subjective and rely on the experience of the clinician. The robotic knee testing (RKT) device ... Read more
The aetiology of pain in chronic midportion Achilles tendinopathy

Author: Mkumbuzi, Nonhlanhla Sharon Date: 2021 Background Achilles tendinopathy (AT) is a common injury in athletes and sedentary individuals, which presents as pain and loss of function in the lower limb. Tendon pathology can exist without pain, but the hallmark of the condition is pain, ... Read more

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Browsing by Author "September, Alison"

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