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Browsing by Author "Seldon, Ronnett"

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Altered ratio of IFN-γ/IL-10 in patients with drug resistant Mycobacterium tuberculosis and HIV-tuberculosis immune reconstitution inflammatory syndrome

Author: Skolimowska, Keira H ; Rangaka, Molebogeng X ; Meintjes, Graeme ; Pepper, Dominique J ; Seldon, Ronnett ; Matthews, Kerryn ; Wilkinson, Robert J ; Wilkinson, Katalin A Date: 2012 We have described a clinical relationship between HIV-Tuberculosis Immune Reconstitution Inflammatory Syndrome (TB-IRIS) and anti-tubercular drug resistance. Here we studied the immune response of TB-IRIS patients from whom a drug-resistant ... Read more c b
Easy-To-Access Quinolone Derivatives Exhibiting Antibacterial and Anti-Parasitic Activities

Author: Beteck, Richard M ; Jordaan, Audrey ; Seldon, Ronnett ; Laming, Dustin ; Hoppe, Heinrich C ; Warner, Digby F ; Khanye, Setshaba D Date: 20 Feb 2021 The cell wall of Mycobacterium tuberculosis (Mtb) has a unique structural organisation, comprising a high lipid content mixed with polysaccharides. This makes cell wall a formidable barrier impermeable to hydrophilic agents. In addition, ... Read more
Identification of Antimycobacterial Natural Products from a Library of Marine Invertebrate Extracts

Author: Acquah, Kojo Sekyi ; Beukes, Denzil R ; Seldon, Ronnett ; Jordaan, Audrey ; Sunassee, Suthananda N ; Warner, Digby F ; Gammon, David W Date: 28 Jan 2022 Tuberculosis (TB) remains a public health crisis, requiring the urgent identification of new anti-mycobacterial drugs. We screened several organic and aqueous marine invertebrate extracts for their in vitro inhibitory activity against the ... Read more c b
Impairment of IFN-gamma response to synthetic peptides of mycobacterium tuberculosis in a 7-day whole blood assay

Author: Gideon, Hannah Priyadarshini ; Hamilton, Melissa Shea ; Wood, Kathryn ; Pepper, Dominique ; Oni, Tolu ; Seldon, Ronnett ; Banwell, Claire ; Langford, Paul R ; Wilkinson, Robert J ; Wilkinson, Katalin A Date: 2013 Studies on Mycobacterium tuberculosis (MTB) antigens are of interest in order to improve vaccine efficacy and to define biomarkers for diagnosis and treatment monitoring. The methodologies used for these investigations differ greatly between ... Read more c b
The Phenotypical Analysis of Mycobacterium Tuberculosis Specific CD4 T Cells that expand during combined antiretroviral therapy in people with latent turbeculosis infection

Author: Seldon, Ronnett Date: 2009 Read more
Smoking, BCG and employment and the risk of tuberculosis infection in HIV-infected persons in South Africa

Author: Oni, Tolu ; Gideon, Hannah P ; Bangani, Nonzwakazi ; Tsekela, Relebohile ; Seldon, Ronnett ; Wood, Kathryn ; Wilkinson, Katalin A ; Goliath, Rene T ; Ottenhoff, Tom H M ; Wilkinson, Robert J Date: 2012 BACKGROUND: The increased susceptibility to latent tuberculosis infection (LTBI) of HIV-1-infected persons represents a challenge in TB epidemic control. However few studies have evaluated LTBI predictors in a generalized HIV/TB epidemic ... Read more c b

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Browsing by Author "Seldon, Ronnett"

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