OpenUCT Home
→
Browsing by Author

Browsing by Author "Scheffler, Konrad"

Now showing items 1-5 of 5

Evidence of HIV-1 adaptation to host HLA alleles following chimp-to-human transmission

Author: Ngandu, Nobubelo ; Seoighe, Cathal ; Scheffler, Konrad Date: 2009 BACKGROUND:The cytotoxic T-lymphocyte immune response is important in controlling HIV-1 replication in infected humans. In this immune pathway, viral peptides within infected cells are presented to T-lymphocytes by the polymorphic human ... Read more c b
Extensive purifying selection acting on synonymous sites in HIV-1 Group M sequences

Author: Ngandu, Nobubelo ; Scheffler, Konrad ; Moore, Penny ; Woodman, Zenda ; Martin, Darren ; Seoighe, Cathal Date: 2008 BACKGROUND: Positive selection pressure acting on protein-coding sequences is usually inferred when the rate of nonsynonymous substitution is greater than the synonymous rate. However, purifying selection acting directly on the nucleotide ... Read more c b
Frequent toggling between alternative amino acids is driven by selection in HIV-1

Author: Delport, Wayne ; Scheffler, Konrad ; Seoighe, Cathal Date: 2008 Author Summary Viruses, such as HIV, are able to evade host immune responses through escape mutations, yet sometimes they do so at a cost. This cost is the reduction in the ability of the virus to replicate, and thus selective pressure exists ... Read more c b
Genome-wide survey of allele-specific splicing in humans

Author: Nembaware, Victoria ; Lupindo, Bukiwe ; Schouest, Katherine ; Spillane, Charles ; Scheffler, Konrad ; Seoighe, Cathal Date: 2008 BACKGROUND: Accurate mRNA splicing depends on multiple regulatory signals encoded in the transcribed RNA sequence. Many examples of mutations within human splice regulatory regions that alter splicing qualitatively or quantitatively have been ... Read more c b
Non-Negative Matrix Factorization for Learning Alignment-Specific Models of Protein Evolution

Author: Murrell, Ben ; Weighill, Thomas ; Buys, Jan ; Ketteringham, Robert ; Moola, Sasha ; Benade, Gerdus ; Buisson, Lise du ; Kaliski, Daniel ; Hands, Tristan ; Scheffler, Konrad Date: 2011 Models of protein evolution currently come in two flavors: generalist and specialist. Generalist models (e.g. PAM, JTT, WAG) adopt a one-size-fits-all approach, where a single model is estimated from a number of different protein alignments. ... Read more c b

Now showing items 1-5 of 5

Browse

All of OpenUCT

Browsing by Author "Scheffler, Konrad"

Browsing by Author "Scheffler, Konrad"

Browse

All of OpenUCT