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Browsing by Author "Rybicki, Ed"

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Assessing TMV as an immunogenic particle : the expression of HIV-1 subtype C V3 loop neutralizing antibody epitopes on the surface of TMV virions

Author: Valley-Omar, Ziyaad Date: 2005 In an attempt to establish a plant-based Human immunodeficiency virus-1 (HIV-1) subtype C neutralizing antibody stimulating vaccine, a Tobacco mosaic virus (TMV) derived vector was used to express recognized HIV neutralizing antibody epitopes. ... Read more
Beak and feather disease virus candidate vaccine development

Author: Duvenage, Lucian Date: 2012 [Fix supervisors field.] Psittacine beak and feather disease, caused by a circovirus known as beak and feather disease virus (BFDV), is a threat to both wild and captive psittacine species. There is currently no vaccine against BFDV and safe ... Read more
BioMed Central Membership

Author: Rybicki, Ed Date: May 2012 BioMed Central is an internet publishing platform, recently purchased by Springer. They publish a suite of 233 Open Access peer-reviewed biomedical journals online, which are now joined by another, more social science-oriented set of offerings ... Read more c b a
Construction and characterization of chimaeric human immunodefiency virus type 1 subtype C Gag virus-like particles

Author: Halsey, Richard James Date: 2006 In this study I explored the possibility of making HIV-1 subtype C Pr55gag-based chimaeric virus-like particles (VLPs) as a boost to the HIV-IC multigene DNA vaccine pTHr.grttnC, which encodes a modified Gag-RT-Tat-Nef fusion protein (GRTTN). ... Read more
Development of candidate Human papillomavirus vaccines

Author: Varsani, Arvind Date: 2003 The objective of this thesis was to investigate novel and plant-based vaccines against the Human papillomavirus type 16 (HPV-16), which is primarily responsible for cervical cancer. As a first study, the L1 gene of a South Africna variant of ... Read more
Development of plant-produced African horse sickness vaccines

Author: Dennis, Susan Jennifer Date: 2019 African horse sickness is a devastating disease that causes great suffering and many fatalities amongst horses in sub-Saharan Africa. It is caused by nine different serotypes of the orbivirus African horse sickness virus (AHSV) and it is ... Read more
Development of West Nile virus candidate vaccines in Nicotiana benthamiana

Author: Wayland, Jennifer Date: 2021 West Nile virus (WNV) is a widely disseminated flavivirus, with a geographical range that now includes Africa, America, Europe, the Middle East, West Asia and Australia. The virus is vectored by Culex mosquitoes and is maintained in a ... Read more
Experimental investigations of mastrevirus molecular biology and evolution

Author: Van der Walt, Eric Date: 2008 This dissertation describes three major sets of experiments, all of which involved the construction and use of various reciprocal chimaeric MSV constructs. First, chimaeric viruses were used in genetic complementation-type experiments to ... Read more
Expression of HIV-1 subtype C nef in E. coli and Nicotiana benthamiana : development of plant-based vaccines for HIV

Author: Bandawe, Gama Date: 2003 Expression of the nefgene from HIV-1 subtype C in Nicotiana benthamiana was carried out using a TMV -based vector with the aim of developing a plant-based candidate vaccine for HIV-1. The nef gene of the DU151 isolate of mV-l subtype C taken ... Read more
Expression of HPV-16 L2 in plants

Author: Pereira, Roman Date: 2008 This study demonstrates high level expression of L2, 25 mg.kg⁻¹of leaf material, is achievable. Interestingly, expression was best when coded for by a mammalian codon-optimized form of the L2 gene as opposed to the wildtype or plant codon-optimized ... Read more
Generation and characterization of HIV-1 subtype C candidate vaccines that will induce high titre antibody responses to HIV-1 envelope glycoprotein

Author: van Diepen, Michiel Theodoor Date: 2020 Despite huge strides being made towards decreasing the number of individuals getting newly infected with HIV-1, and in reducing AIDS-related deaths, unfortunately current predictions are that the 2020 UNAIDS goals (90-90-90 targets, where 90% ... Read more
HPV pseudovirion production in plants

Author: Kennedy, Paul Date: 2013 Human papilloma virus (HPV) infection is the most common etiological agent of cervical cancer, the most common cancer in women in Africa. The lifecycle of HPV has historically made the virus difficult to culture in vitro, and this has hindered ... Read more
Human papillomavirus prevalence, viral load and pre-cancerous lesions of the cervix in women initiating highly active antiretroviral therapy in South Africa: a cross-sectional study

Author: Moodley, Jennifer ; Constant, Deborah ; Hoffman, Margaret ; Salimo, Anna ; Allan, Bruce ; Rybicki, Ed ; Hitzeroth, Inga ; Williamson, Anna Lise Date: 2009 BACKGROUND:Cervical cancer and infection with human immunodeficiency virus (HIV) are both important public health problems in South Africa (SA). The aim of this study was to determine the prevalence of cervical squamous intraepithelial lesions ... Read more c b
An in depth study of human papillomavirus diversity in South African women infected with HIV

Author: Salimo, Anna T Date: 2009 Cervical cancer is the second most common cancer affecting women and in most developing countries it remains the leading cause of cancer deaths. In South Africa, more than 3 400 women succumb to the disease every year and 1 in 31 women develop ... Read more
Introduction to Molecular Virology

Author: Rybicki, Ed Date: 16 Sep 2014 Introductory Virology for 2nd and 3rd year courses. The material consists of a series of linked pages exploring an introduction to the concept of viruses, and an exploration of their general properties. Virology teaching material used for ... Read more c b n d
An investigation into improved HIV-1 subtype C envelope based vaccine design

Author: Margolin, Emmanuel Aubrey Date: 2014 Includes abstract. Includes bibliographical references. Read more
An investigation into the development of plant-derived vaccines against human papillomavirus type 11 and Cottontail rabbit papillomavirus

Author: Kohl, Thomas Oliver Date: 2004 The principal object of this thesis was to investigate the feasibility of developing a novel plant-derived vaccine against Human papillomavirus type 11 (HPV -11), the causal agent of genital warts and laryngeal condylomas. A secondary objective ... Read more
Investigation of particulate HIV-1 Env vaccine candidates using Zera® and SpyTag/SpyCatcher technologies

Author: Ximba, Phindile Thobeka Date: 2022 The HIV-1 envelope glycoprotein (Env) is the primary focus of prophylactic HIV vaccine development. However, the unusually low density of Env spikes on the virion (≈14 spikes/virion) is unfavourable for eliciting high titre, long-lasting ... Read more
Investigations of the molecular determinants of maize streak virus replication

Author: Willment, Janet Anne Date: 1999 Geminiviruses replicate via a rolling circle mechanism, which initiates at the origin of replication located within the long intergenic region (LIR). The viral replication associated-protein (Rep) in conjunction with the host's DNA replication ... Read more
Isolation, identification and characterisation of three viruses from Pisum sativum in South Africa

Author: Jooste, A E C Date: 2000 Three virus isolates from pea plants (Pisum sativum) from different regions in South Africa were identified and are discussed in this thesis. A number of techniques were used to identify the viruses including serology, electron microscopy, ... Read more

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