OpenUCT Home
→
Browsing by Author

Browsing by Author "Russell, Vivienne A"

Now showing items 1-15 of 15

Developmental stress elicits preference for methamphetamine in the spontaneously hypertensive rat model of attention-deficit/hyperactivity disorder

Author: Womersley, Jacqueline S ; Mpeta, Bafokeng ; Dimatelis, Jacqueline J ; Kellaway, Lauriston A ; Stein, Dan J ; Russell, Vivienne A Date: 17 Jun 2016 Background: Developmental stress has been hypothesised to interact with genetic predisposition to increase the risk of developing substance use disorders. Here we have investigated the effects of maternal separation-induced developmental ... Read more c b
Effect of age and unilateral dopamine depletion on striatal NMDA receptor function

Author: Khoboko, Thabelo Date: 2005 Includes bibliographical references. Read more
The effect of exercise on spatial learning and hippocampal proteins in maternally separated adult rats

Author: Makena, Nokuthula Date: 2014 Repeated maternal separation (MS) has been reported to induce changes in hypothalamic-pituitary- adrenal (HPA) axis activity leading to abnormal stress responses later in life. Such alterations have also been linked to poor cognitive function. ... Read more
The effect of light on a rat model of depression

Author: Mtintsilana, Asanda Date: 2014 Background: Depression is a debilitating mood disorder, negatively affecting an individual’s health and well-being. Despite this, the aetiology of depression remains poorly understood. Consistently, depression treatments are far from satisfactory ... Read more
Effect of maternal separation on stress-related proteins measured in a 6-hydroxydopamine rat model of Parkinson’s disease

Author: Tomes, Hayley Sarah Date: 2014 The developing central nervous system is especially vulnerable and research has implicated early life stress (ELS) as a potentiating factor to cell death in a rat model of Parkinson’s disease (PD). PD is a movement disorder resulting from the ... Read more
The effect of voluntary exercise on adult hippocampal neurogenesis in maternally separated rats

Author: Hardcastle, Natasha Sema Date: 2016 Maternal separation (MS) has been shown to produce depression-like symptoms in male Sprague Dawley rats. The underlying mechanisms responsible for the development of these depression-like behaviors are unknown. However, a growing body of ... Read more
The effects of early developmental stress and exercise intervention on neurodegeneration in a rat model of Parkinson's disease

Author: Warton, Fleur L Date: 2010 Early developmental stress has been shown to produce numerous deleterious effects, e.g. the later development of affective disorders, and this has been related to chronic enhanced hypothalamic-pituitary-adrenal axis activity. Animal studies ... Read more
Locus-coeruleus norepinephrine system function in a developmental animal model of schizophrenia: the socially isolated rat

Author: Atmore, Katherine H Date: 2017 Introduction: Schizophrenia is a chronic, debilitating mental disorder characterised by positive, negative and cognitive symptoms. Current treatment regimens fail to adequately address the cognitive and negative symptoms of the disorder. ... Read more
Methamphetamine and cocaine effects on dopamine neurons in a rat model of developmental stress and attention-deficit/hyperactivity disorder

Author: Womersley, Jacqueline Samantha Date: 2014 Attention-deficit/hyperactivity disorder (ADHD) is a developmental disorder characterised by age-inappropriate levels of inattention, hyperactivity and impulsivity and is theorised to be caused by dopaminergic dysregulation. Developmental ... Read more
Perceived mental effort correlates with changes in tonic arousal during attentional tasks

Author: Howells, Fleur M ; Stein, Dan J ; Russell, Vivienne A Date: 2010 Background: It has been suggested that perceived mental effort reflects changes in arousal during tasks of attention. Such changes in arousal may be tonic or phasic, and may be mediated by the locus-coeruleus norepinephrine (LC-NE) system. ... Read more
A Role for glutamate and Gaba in attention-deficit/hyperactivity disorder: a study of the spontaneously hypertensive rat

Author: Sterley, Toni-Lee Date: 2014 Attention-deficit/hyperactivity disorder (ADHD) is a heterogeneous, developmental disorder characterised by behavioural symptoms of inattention, hyperactivity, and impulsivity. The present thesis investigated how the main excitatory and ... Read more
A study of an animal model of Attention-Deficit/ Hyperactivity Disorder using in vivo chronoamperometry and behavioural responses to methylphenidate and guanfacine

Author: Hsin-Wen Hsieh, Jennifer Date: 2010 Attention-Deficit/Hyperactivity Disorder (ADHD) is a childhood disorder that is behaviorally characterized by developmentally inappropriate levels of inattention, impulsivity and hyperactivity. Among several hypotheses of ADHD etiology the ... Read more
A study of glutamate receptor function in the rat barrel cortex

Author: Lehohla, Molupe Date: 2001 Bibliography: leaves 137-156. Read more
A study of the WKY as a rat model of depression

Author: Van Zyl, Petrus Jurgens Date: 2015 Major depression is a heterogeneous neuropsychiatric disorder with a significant genetic - stress interaction. The Wistar - Kyoto (WKY) rat displays hypersensitivity to stress and depression - like behaviour and is used as a genetic model of ... Read more
The effects of prenatal and early-postnatal ethanol exposure on rat brain neurochemistry and behaviour

Author: Swart, Patricia Cathryn Date: 2018 Foetal alcohol spectrum disorder (FASD), the umbrella term used to describe the wide range of cognitive and behavioural deficits observed after exposure to alcohol in utero, is a major public health issue specifically in South Africa. South ... Read more