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Browsing by Author "Rebe, Kevin"

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Clinical and financial burdens of secondary level care in a public sector antiretroviral roll-out setting (G F Jooste Hospital)

Author: Kevany, Sebastian ; Meintjes, Graeme ; Rebe, Kevin ; Maartens, Gary ; Cleary, Susan Date: 2009 Background: Antiretroviral therapy (ART) is being extended across South Africa. While efforts have been made to assess the costs of providing ART via accredited service points, little information is available on its downstream costs, particularly ... Read more c b
Clinical deterioration during antitubercular treatment at a district hospital in South Africa: the importance of drug resistance and AIDS defining illnesses

Author: Pepper, Dominique J ; Rebe, Kevin ; Morroni, Chelsea ; Wilkinson, Robert J ; Meintjes, Graeme Date: 2009 BACKGROUND: Clinical deterioration on drug therapy for tuberculosis is a common cause of hospital admission in Africa. Potential causes for clinical deterioration in settings of high HIV-1 prevalence include drug resistant Mycobacterium ... Read more c b
Comparison of an in-house real-time duplex PCR assay with commercial HOLOGIC® APTIMA assays for the detection of Neisseria gonorrhoeae and Chlamydia trachomatis in urine and extra-genital specimens

Author: Venter, Johanna M E ; Mahlangu, Precious M ; Müller, Etienne E ; Lewis, David A ; Rebe, Kevin ; Struthers, Helen ; McIntyre, James ; Kularatne, Ranmini S Date: 03 Jan 2019 Abstract Background Extra-genital Neisseria gonorrhoeae and Chlamydia trachomatis infections are mostly asymptomatic, and important reservoir sites of infection as they often go undetected and ... Read more
Cost effectiveness analysis of two alternative interventions for the integration of Tenofovir into South Africa's public sector First Line Antiretroviral treatment regimen

Author: Lin, Iming Date: 2009 In 2003, South Africa's National Department of Health (DoH) initiated the roll out of antiretroviral therapy (ART) for HIV positive individuals in the public health sector. Based on World Health Organization (WHO) guidelines, South Africa's ... Read more
A cross sectional analysis of Gonococcal and Chlamydial infections among men-who-have-sex-with-men in Cape Town, South Africa

Author: Rebe, Kevin ; Lewis, David ; Myer, Landon ; de Swardt, Glenn ; Struthers, Helen ; Kamkuemah, Monika ; McIntyre, James Date: 2015 BACKGROUND: Men-who-have-sex-with-men (MSM) are at high risk of HIV and sexually transmitted infection (STI) transmission. Asymptomatic STIs are common in MSM and remain undiagnosed and untreated where syndromic management is advocated. ... Read more c b
Cryptococcal immune reconstitution inflammatory syndrome presenting with erosive bone lesions, arthritis and subcutaneous abscesses

Author: Burton, Rosie ; Gogela, Neliswa ; Rebe, Kevin ; McNally, Matt ; Meintjes, Graeme Date: 2009 A 35-year-old South African man was diagnosed with pulmonary tuberculosis (TB) in August 2007 and started on a 6-month course of treatment (intensive phase of rifampicin, isoniazid, ethambutol and pyrazinamide for 2 months, followed by ... Read more
Detectable HIV-1 in semen in individuals with very low blood viral loads

Author: Kariuki, Samuel M ; Selhorst, Philippe ; Norman, Jennifer ; Cohen, Karen ; Rebe, Kevin ; Williamson, Carolyn ; Dorfman, Jeffrey R Date: 05 Mar 2020 Abstract Background Several reports indicate that a portion (5–10%) of men living with HIV-1 intermittently shed HIV-1 RNA into seminal plasma while on long term effective antiretroviral therapy (ART). This is highly suggestive of an HIV-1 ... Read more
Early severe morbidity and resource utilization in South African adults on antiretroviral therapy

Author: de Cherif, Teresa ; Schoeman, Jan ; Cleary, Susan ; Meintjes, Graeme ; Rebe, Kevin ; Maartens, Gary Date: 2009 BACKGROUND:High rates of mortality and morbidity have been described in sub-Saharan African patients within the first few months of starting highly active antiretroviral therapy (HAART). There is limited data on the causes of early morbidity ... Read more c b
Mortality in patients treated for tuberculous pericarditis in sub-Saharan Africa.

Author: Mayosi, Bongani M ; Wiysonge, Charles Shey ; Ntsekhe, Mpiko ; Gumedze, Freedom ; Volmink Jimmy A ; Maartens, Gary ; Aje, Akinyemi ; Thomas, Baby M ; Thomas, Kandathil M ; Awotedu, Abolade A ; Bongani, Thembela ; Mntla, Phindile ; Maritz, Frans ; Blackett, Kathleen Ngu ; Nkouonlack, Duquesne C ; Burch, Vanessa C ; Rebe, Kevin ; Parrish, Andy ; Sliwa, Karen ; Vezi, Brian Z ; Alam, Nowshad ; Brown, Basil G ; Gould, Trevor ; Visser, Tim ; Magula, Nombulelo P ; Commerford, Patrick J Date: 2008 Tuberculous pericarditis is one of the most severe forms of extrapulmonary tuberculosis, causing death or disability in a substantial proportion of affected people.1,2 In Africa, the incidence of tuberculous pericarditis is rising as a result ... Read more
Randomized placebo-controlled trial of prednisone for paradoxical tuberculosis-associated immune reconstitution inflammatory syndrome

Author: Meintjes, Graeme ; Wilkinson, Robert J ; Morroni, Chelsea ; Pepper, Dominique J ; Rebe, Kevin ; Rangaka, Molebogeng X ; Oni, Tolu ; Maartens, Gary Date: 2010 Objective: Paradoxical tuberculosis-associated immune reconstitution inflammatory syndrome (TB-IRIS) is a frequent complication of antiretroviral therapy in resource-limited countries. We aimed to assess whether a 4 week course of prednisone ... Read more
Reduced referral and case fatality rates for severe symptomatic hyperlactataemia in a South African public sector antiretroviral programme: a retrospective observational study

Author: Schutz, Charlotte ; Boulle, Andrew ; Stead, Dave ; Rebe, Kevin ; Osler, Meg ; Meintjes, Graeme Date: 2010 BACKGROUND: Interventions to promote prevention and earlier diagnosis of severe symptomatic hyperlactataemia (SHL) were implemented in the Western Cape provincial antiretroviral programme (South Africa) from 2004. Interventions included ... Read more c b
Relationship of cerebrospinal fluid pressure, fungal burden and outcome in patients with cryptococcal meningitis undergoing serial lumbar punctures

Author: Bicanic, Tihana ; Brouwer, Annemarie E ; Meintjes, Graeme ; Rebe, Kevin ; Limmathurotsakul, Direk ; Chierakul, Wirongrong ; Teparrakkul, Praprit ; Loyse, Angela ; White, Nicholas J ; Wood, Robin ; Jaffar, Shabbar ; Harrison, Thomas Date: 2009 Objectives: To assess impact of serial lumbar punctures on association between cerebrospinal fluid (CSF) opening pressure and prognosis in HIV-associated cryptococcal meningitis; to explore time course and relationship of opening pressure ... Read more
Symptomatic relapse of HIV-associated cryptococcal meningitis in South Africa: The role of inadequate secondary prophylaxis

Author: Jarvis, Joseph N ; Meintjes, Graeme ; Williams, Zomzi ; Rebe, Kevin ; Harrison, Thomas S Date: 2010 Objectives. Cryptococcal meningitis is the most common cause of adult meningitis in southern Africa. Much of this disease burden is thought to be due to symptomatic relapse of previously treated infection. We studied the contribution of ... Read more

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