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Browsing by Author "Randall, Philippa"

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Early morning urine collection to improve the sensitivity of LAM in hospitalised TB/HIV co-infected patients

Author: Gina, Ntombenhle Phindile Date: 2016 Point-of-care detection of urine lipoarabinomannan (LAM) is a low-cost rapid TB diagnostic for use in HIV co-infected patients. However, its sensitivity in these patients is suboptimal. Strategies to improve its performance is a need. The ... Read more
Reactivation of M. tuberculosis infection in trans-membrane tumour necrosis factor mice

Author: Dambuza, Ivy ; Keeton, Roanne ; Allie, Nasiema ; Hsu, Nai-Jen ; Randall, Philippa ; Sebesho, Boipelo ; Fick, Lizette ; Quesniaux, Valerie J F ; Jacobs, Muazzam Date: 2011 Of those individuals who are infected with M. tuberculosis , 90% do not develop active disease and represents a large reservoir of M. tuberculosis with the potential for reactivation of infection. Sustained TNF expression is required for ... Read more c b
TNF-dependent regulation and activation of innate immune cells are essential for host protection against cerebral tuberculosis

Author: Francisco, Ngiambudulu ; Hsu, Nai-Jen ; Keeton, Roanne ; Randall, Philippa ; Sebesho, Boipelo ; Allie, Nasiema ; Govender, Dhirendra ; Quesniaux, Valerie ; Ryffel, Bernhard ; Kellaway, Lauriston ; Jacobs, Muazzam Date: 2015 BACKGROUND: Tuberculosis (TB) affects one third of the global population, and TB of the central nervous system (CNS-TB) is the most severe form of tuberculosis which often associates with high mortality. The pro-inflammatory cytokine tumour ... Read more c b

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Browsing by Author "Randall, Philippa"

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