Browsing by Author "Pillay, Sirika"

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Chimaeric HIV-1 subtype C Gag molecules with large in-frame C-terminal polypeptide fusions form virus-like particles.

Author: Halsey, Richard J ; Tanzer, Fiona L ; Meyers, Ann ; Pillay, Sirika ; Lynch, Alisson ; Shephard, Enid ; Williamson, Anna-Lise ; Rybicki, Edward P Date: 2008 HIV-1 Pr55 Gag virus-like particles (VLPs) are strong immunogens with potential as candidate HIV vaccines. VLP immunogenicity can be broadened by making chimaeric Gag molecules: however, VLPs incorporating polypeptides longer than 200 aa fused ... Read more
HIV-1 sub-type C chimaeric VLPs boost cellular immune responses in mice

Author: Pillay, Sirika ; Shephard, Enid ; Meyers, Ann ; Williamson, Anna-Lise ; Rybicki, Edward P Date: 2010 Several approaches have been explored to eradicate HIV; however, a multigene vaccine appears to be the best option, given their proven potential to elicit broad, effective responses in animal models. The Pr55Gag protein is an excellent vaccine ... Read more c b
Optimization of chimaeric HIV-1 virus-like particle (VLP) production and immunogenicity testing of VLPs in mice

Author: Pillay, Sirika Date: 2008 The devastating effect the HIV pandemic has had on the human population in the last twenty five years has highlighted the great need to develop a prophylactic HIV vaccine. The manufacture of a vaccine has proven difficult though, with a number ... Read more

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