Browsing by Author "Pienaar, Sandra"

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Polymorphic variation in TIRAP is not associated with susceptibility to childhood TB but may determine susceptibility to TBM in some ethnic groups

Author: Dissanayeke, Shobana Rebecca ; Levin, Samuel ; Pienaar, Sandra ; Wood, Kathryn ; Eley, Brian ; Beatty, David ; Henderson, Howard ; Anderson, Suzanne ; Levin, Michael Date: 2009 Host recognition of mycobacterial surface molecules occurs through toll like receptors (TLR) 2 and 6. The adaptor protein TIRAP mediates down stream signalling of TLR2 and 4, and polymorphisms in the TIRAP gene ( TIRAP ) have been associated ... Read more c b
X-linked Hyper IgM (HIGM1) in an African kindred: the first report from South Africa

Author: Pienaar, Sandra ; Eley, Brian ; Hughes, Jane ; Henderson, Howard Date: 2003 BACKGROUND:The objective of this study was to describe the clinical and molecular features of the first South African family with X-linked hyper-IgM syndrome (HIGM1). METHODS: Diagnoses were based on immunoglobulin results and the absence of ... Read more c b

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