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Browsing by Author "Peter, Jonathan G"

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Approaches to the diagnosis of smear-negative and sputum-scarce TB in South Africa

Author: Peter, Jonathan G Date: 2013 In South Africa, an HIV-endemic setting, the burden of smear-negative (SN) and sputum-scarce (SS) TB is a major public health catastrophe. Diagnostic delay or failure is a key bottleneck. We hypothesised that i) assisted sputum smpling using ... Read more
Can point-of-care urine LAM strip testing for tuberculosis add value to clinical decision making in hospitalised HIV-infected persons

Author: Peter, Jonathan G ; Theron, Grant ; Dheda, Keertan Date: 2013 BACKGROUND: The urine lipoarabinomannan (LAM) strip-test (Determine®-TB) can rapidly rule-in TB in HIV-infected persons with advanced immunosuppression. However, given high rates of empiric treatment amongst hospitalised patients in high-burden ... Read more c b
Delirium in general medical in-patients in South Africa: development of the 4-question "RACY" tool for simple and effective delirium screening by Jonathan G. Peter.

Author: Peter, Jonathan G Date: 2012 Includes abstract. Includes bibliographical references. Read more
Diagnostic accuracy of quantitative PCR (Xpert MTB/RIF) for tuberculous pericarditis compared to adenosine deaminase and unstimulated interferon-γ in a high burden setting: a prospective study

Author: Pandie, Shaheen ; Peter, Jonathan G ; Kerbelker, Zita S ; Meldau, Richard ; Theron, Grant ; Govender, Ureshnie ; Ntsekhe, Mpiko ; Dheda, Keertan ; Mayosi, Bongani M Date: 18 Jun 2014 Background: Tuberculous pericarditis (TBP) is associated with high morbidity and mortality, and is an important treatable cause of heart failure in developing countries. Tuberculous aetiology of pericarditis is difficult to diagnose promptly. ... Read more
The diagnostic accuracy of urine-based Xpert MTB/RIF in HIV-infected hospitalized patients who are smear-negative or sputum scarce

Author: Peter, Jonathan G ; Theron, Grant ; Muchinga, Tapuwa E ; Govender, Ureshnie ; Dheda, Keertan Date: 2012 BACKGROUND: Hospitals in sub-Saharan Africa are inundated with HIV-infected patients and tuberculosis (TB) is the commonest opportunistic infection in this sub-group. Up to one third of TB-HIV co-infected patients fail to produce a sputum ... Read more c b
Early morning urine collection to improve the sensitivity of LAM in hospitalised TB/HIV co-infected patients

Author: Gina, Ntombenhle Phindile Date: 2016 Point-of-care detection of urine lipoarabinomannan (LAM) is a low-cost rapid TB diagnostic for use in HIV co-infected patients. However, its sensitivity in these patients is suboptimal. Strategies to improve its performance is a need. The ... Read more
Feasibility and diagnostic utility of antigen-specific interferon-gamma responses for rapid immunodiagnosis of tuberculosis using induced sputum

Author: Cashmore, Tamaryn J ; Peter, Jonathan G ; Van Zyl-Smit, Richard N ; Semple, Patricia L ; Maredza, Alice ; Meldau, Richard ; Zumla, Alimuddin ; Nurse, Barbara ; Dheda, Keertan Date: 2010 BACKGROUND: The diagnosis of smear-negative or sputum-scarce tuberculosis (TB) is problematic as culture takes several weeks and representative biological samples are difficult to obtain. RD-1 antigen-specific interferon-γ release assays ... Read more c b

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Browsing by Author "Peter, Jonathan G"

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