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Browsing by Author "Pepper, Dominique J"

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Altered ratio of IFN-γ/IL-10 in patients with drug resistant Mycobacterium tuberculosis and HIV-tuberculosis immune reconstitution inflammatory syndrome

Author: Skolimowska, Keira H ; Rangaka, Molebogeng X ; Meintjes, Graeme ; Pepper, Dominique J ; Seldon, Ronnett ; Matthews, Kerryn ; Wilkinson, Robert J ; Wilkinson, Katalin A Date: 2012 We have described a clinical relationship between HIV-Tuberculosis Immune Reconstitution Inflammatory Syndrome (TB-IRIS) and anti-tubercular drug resistance. Here we studied the immune response of TB-IRIS patients from whom a drug-resistant ... Read more c b
Assessment at antiretroviral clinics during TB treatment reduces loss to follow-up among HIV-infected patients

Author: Pepper, Dominique J ; Marais, Suzaan ; Bhaijee, Feriyl ; Wilkinson, Robert J ; De Azevedo, Virginia ; Meintjes, Graeme Date: 2012 Setting: A South African township clinic where loss to follow-up during TB treatment may prevent HIV-infected TB patients from receiving life-saving ART. Objective: To determine factors associated with loss to follow-up during TB treatment. ... Read more c b
Barriers to initiation of antiretrovirals during antituberculosis therapy in Africa

Author: Pepper, Dominique J ; Marais, Suzaan ; Wilkinson, Robert J ; Bhaijee, Feriyl ; De Azevedo, Virginia ; Meintjes, Graeme Date: 2011 BACKGROUND: In the developing world, the principal cause of death among HIV-infected patients is tuberculosis (TB). The initiation of antiretroviral therapy (ART) during TB therapy significantly improves survival, however it is not known which ... Read more c b
Central nervous system disorders afrer starting antiretroviral therapy in South Africa

Author: Asselman, Valerie ; Thienemann, Fredrich ; Pepper, Dominique J ; Boulle, Andrew ; Wilkinson, Robert J ; Graeme Meintjes ; Marais, Suzaan Date: 2010 Objective: To describe the spectrum of central nervous system (CNS) disease during the first year of antiretroviral therapy (ART), and to determine the contribution of neurological immune reconstitution inflammatory syndrome (IRIS). Design: ... Read more
Clinical deterioration during antitubercular treatment at a district hospital in South Africa: the importance of drug resistance and AIDS defining illnesses

Author: Pepper, Dominique J ; Rebe, Kevin ; Morroni, Chelsea ; Wilkinson, Robert J ; Meintjes, Graeme Date: 2009 BACKGROUND: Clinical deterioration on drug therapy for tuberculosis is a common cause of hospital admission in Africa. Potential causes for clinical deterioration in settings of high HIV-1 prevalence include drug resistant Mycobacterium ... Read more c b
Presentation and outcome of tuberculous meningitis in a high HIV prevalence setting

Author: Marais, Suzaan ; Pepper, Dominique J ; Schutz, Charlotte ; Wilkinson, Robert J ; Meintjes, Graeme Date: 2011 BACKGROUND: Mycobacterium tuberculosis is a common, devastating cause of meningitis in HIV-infected persons. Due to international rollout programs, access to antiretroviral therapy (ART) is increasing globally. Starting patients with ... Read more c b
Prolonged tuberculosis-associated immune reconstitution inflammatory syndrome: characteristics and risk factors

Author: Bana, Tasnim M ; Lesosky, Maia ; Pepper, Dominique J ; van der Plas, Helen ; Schutz, Charlotte ; Goliath, Rene ; Morroni, Chelsea ; Mendelson, Marc ; Maartens, Gary ; Wilkinson, Robert J ; Meintjes, Graeme Date: 27 Sep 2016 Background: In a proportion of patients with HIV-associated tuberculosis who develop paradoxical immune reconstitution inflammatory syndrome (IRIS), the clinical course of IRIS is prolonged necessitating substantial health care utilization ... Read more c b
Randomized placebo-controlled trial of prednisone for paradoxical tuberculosis-associated immune reconstitution inflammatory syndrome

Author: Meintjes, Graeme ; Wilkinson, Robert J ; Morroni, Chelsea ; Pepper, Dominique J ; Rebe, Kevin ; Rangaka, Molebogeng X ; Oni, Tolu ; Maartens, Gary Date: 2010 Objective: Paradoxical tuberculosis-associated immune reconstitution inflammatory syndrome (TB-IRIS) is a frequent complication of antiretroviral therapy in resource-limited countries. We aimed to assess whether a 4 week course of prednisone ... Read more

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Browsing by Author "Pepper, Dominique J"

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