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Browsing by Author "Oni, Tolu"

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A mixed methods approach to exploring the moderating factors of implementation fidelity of the integrated chronic disease management model in South Africa

Author: Lebina, Limakatso ; Oni, Tolu ; Alaba, Olufunke A ; Kawonga, Mary Date: 06 Jul 2020 Abstract Background Chronic care models like the Integrated Chronic Disease Management (ICDM) model strive to improve the efficiency and quality of care for patients with chronic diseases. However, there is a dearth of studies assessing the ... Read more
Analysis of Cameroon’s Sectoral Policies on Physical Activity for Noncommunicable Disease Prevention

Author: Tatah, Lambed ; Mapa-Tassou, Clarisse ; Shung-King, Maylene ; Oni, Tolu ; Woodcock, James ; Weimann, Amy ; McCreedy, Nicole ; Muzenda, Trish ; Govia, Ishtar ; Mbanya, Jean Claude ; Assah, Felix Date: 02 Dec 2021 Physical inactivity is increasing in low- and middle-income countries (LMICs), where noncommunicable diseases (NCDs), urbanisation and sedentary living are rapidly growing in tandem. Increasing active living requires the participation of ... Read more c b
Cardio-thoracic ratio is stable, reproducible and has potential as a screening tool for HIV-1 related cardiac disorders in resource poor settings

Author: Esmail, Hanif ; Oni, Tolu ; Thienemann, Friedrich ; Omar-Davies, Nashreen ; Wilkinson, Robert J ; Ntsekhe, Mpiko Date: 2016 BACKGROUND: Cardiovascular disorders are common in HIV-1 infected persons in Africa and presentation is often insidious. Development of screening algorithms for cardiovascular disorders appropriate to a resource-constrained setting could ... Read more c b
Chronic diseases and multi-morbidity - a conceptual modification to the WHO ICCC model for countries in health transition

Author: Oni, Tolu ; McGrath, Nuala ; BeLue, Rhonda ; Roderick, Paul ; Colagiuri, Stephen ; May, Carl R ; Levitt, Naomi S Date: 09 Jun 2014 Background: The burden of non-communicable diseases is rising, particularly in low and middle-income countries undergoing rapid epidemiological transition. In sub-Saharan Africa, this is occurring against a background of infectious chronic ... Read more c b
Completion of isoniazid preventive therapy and factors associated with non-completion in an antiretroviral therapy-naive HIV-infected cohort in Cape Town by Tolu Oni.

Author: Oni, Tolu Date: 2012 TB incidence in South Africa remains high, despite high rates of successful treatment suggesting ongoing transmission and a large reservoir of latently infected persons. Isoniazid preventive therapy (IPT) is recommended as preventive therapy ... Read more
Detectable changes in the blood transcriptome are present after two weeks of antituberculosis therapy

Author: Bloom, Chloe I ; Graham, Christine M ; Berry, Matthew P R ; Wilkinson, Katalin A ; Oni, Tolu ; Rozakeas, Fotini ; Xu, Zhaohui ; Rossello-Urgell, Jose ; Chaussabel, Damien ; Banchereau, Jacques Date: 2012 Rationale: Globally there are approximately 9 million new active tuberculosis cases and 1.4 million deaths annually . Effective antituberculosis treatment monitoring is difficult as there are no existing biomarkers of poor adherence or ... Read more c b
Detection of tuberculosis in HIV-infected and-uninfected African adults using whole blood RNA expression signatures: a case-control study

Author: Kaforou, Myrsini ; Wright, Victoria J ; Oni, Tolu ; French, Neil ; Anderson, Suzanne T ; Bangani, Nonzwakazi ; Banwell, Claire M ; Brent, Andrew J ; Crampin, Amelia C ; Dockrell, Hazel M Date: 2013 Background: A major impediment to tuberculosis control in Africa is the difficulty in diagnosing active tuberculosis (TB), particularly in the context of HIV infection. We hypothesized that a unique host blood RNA transcriptional signature ... Read more c b
Geospatial patterns and determinants of choice of secondary healthcare facilities among National Health Insurance enrolees in Ibadan, Nigeria

Author: Adewole, David Ayobami Date: 2021 Introduction Choice and access to health care are important determinants of health outcomes. Various issues influence choice and determine the degree of, and differences in access to health care. Choice of health care facilities by individuals ... Read more
Hypoxia induces an immunodominant target of tuberculosis specific T cells absent from common BCG vaccines

Author: Gideon, Hannah Priyadarshini ; Wilkinson, Katalin Andrea ; Rustad, Tige R ; Oni, Tolu ; Guio, Heinner ; Kozak, Robert Andrew ; Sherman, David R ; Meintjes, Graeme ; Behr, Marcel A ; Vordermeier, Hans Martin Date: 2010 Author Summary Mycobacterium tuberculosis (the cause of tuberculosis) can persist for many years in humans without causing disease but has the potential to reactivate. One of the conditions the bacterium must survive in these circumstances ... Read more c b
Impairment of IFN-gamma response to synthetic peptides of mycobacterium tuberculosis in a 7-day whole blood assay

Author: Gideon, Hannah Priyadarshini ; Hamilton, Melissa Shea ; Wood, Kathryn ; Pepper, Dominique ; Oni, Tolu ; Seldon, Ronnett ; Banwell, Claire ; Langford, Paul R ; Wilkinson, Robert J ; Wilkinson, Katalin A Date: 2013 Studies on Mycobacterium tuberculosis (MTB) antigens are of interest in order to improve vaccine efficacy and to define biomarkers for diagnosis and treatment monitoring. The methodologies used for these investigations differ greatly between ... Read more c b
Intersectoral Action for Addressing NCDs through the Food Environment: An Analysis of NCD Framing in Global Policies and Its Relevance for the African Context

Author: Weimann, Amy ; Shung-King, Maylene ; McCreedy, Nicole ; Tatah, Lambed ; Mapa-Tassou, Clarisse ; Muzenda, Trish ; Govia, Ishtar ; Were, Vincent ; Oni, Tolu Date: 26 Oct 2021 Noncommunicable diseases contribute the greatest to global mortality. Unhealthy diet—a prominent risk factor—is intricately linked to urban built and food environments and requires intersectoral efforts to address. Framings of the noncommunicable ... Read more c b
Intersectoral policy approaches to healthy cities with a focus on built and food environments

Author: Weimann, Amy Date: 2021 Rapid urbanisation in many low- and middle-income countries in Africa has led to substantial changes in both built and food environments, with resultant changes to housing and diet, respectively. These changes interact with factors that ... Read more
Missed opportunities for NCD multimorbidity prevention in adolescents and youth living with HIV in urban South Africa

Author: Kamkuemah, Monika ; Gausi, Blessings ; Oni, Tolu Date: 01 Jun 2020 Abstract Background Epidemiological transition in high HIV-burden settings is resulting in a rise in HIV/NCD multimorbidity. The majority of NCD risk behaviours start during adolescence, making this an important target group for NCD ... Read more
Patterns of HIV, TB, and non-communicable disease multi-morbidity in an informal peri-urban setting in Cape Town, South Africa

Author: Oni, Tolu Date: 2015 BACKGROUND: Many low and middle-income countries are experiencing colliding epidemics of chronic infectious (ID) and non-communicable diseases (NCD). As a result, the prevalence of multiple morbidities (MM) is rising. METHODS: We conducted a ... Read more
Patterns of HIV, TB, and non-communicable disease multi-morbidity in peri-urban South Africa- a cross sectional study

Author: Oni, Tolu ; Youngblood, Elizabeth ; Boulle, Andrew ; McGrath, Nuala ; Wilkinson, Robert J ; Levitt, Naomi S Date: 17 Jan 2015 Background: Many low and middle-income countries are experiencing colliding epidemics of chronic infectious (ID) and non-communicable diseases (NCD). As a result, the prevalence of multiple morbidities (MM) is rising. Methods: We conducted a ... Read more c b
Process evaluation of implementation fidelity of the integrated chronic disease management model in two districts, South Africa

Author: Lebina, Limakatso ; Alaba, Olufunke ; Ringane, Ashley ; Hlongwane, Khuthadzo ; Pule, Pogiso ; Oni, Tolu ; Kawonga, Mary Date: 16 Dec 2019 Abstract Background The Integrated Chronic Disease Management (ICDM) model has been implemented in South Africa to enhance quality of clinical services in Primary Healthcare (PHC) clinics in a context of a high prevalence of chronic conditions ... Read more
Protocol for a Multi-Level Policy Analysis of Non-Communicable Disease Determinants of Diet and Physical Activity: Implications for Low- and Middle-Income Countries in Africa and the Caribbean

Author: Shung-King, Maylene ; Weimann, Amy ; McCreedy, Nicole ; Tatah, Lambed ; Mapa-Tassou, Clarisse ; Muzenda, Trish ; Govia, Ishtar ; Were, Vincent ; Oni, Tolu Date: 10 Dec 2021 Non-communicable diseases (NCDs) are the leading cause of death globally. Despite significant global policy development for addressing NCDs, the extent to which global policies find expression in low-and-middle income countries’ (LMIC) ... Read more c b
A qualitative study on the experiences and perspectives of public sector patients in Cape Town in managing the workload of demands of HIV and type 2 diabetes co-morbidity

Author: Matima, Rangarirai Date: 2016 Health systems' strengthening is essential in South Africa in an era of the convergence of communicable and non-communicable diseases. Whilst TB is ranked first in all-cause mortality, non-communicable diseases which include cerebrovascular ... Read more
QuantiFERON conversion following tuberculin administration is common in HIV infection and relates to baseline response

Author: Esmail, Hanif ; Thienemann, Friedrich ; Oni, Tolu ; Goliath, Rene ; Wilkinson, Katalin A ; Wilkinson, Robert J Date: 07 Oct 2016 Background: HIV-1 infection impairs tuberculosis (TB) specific immune responses affecting the diagnosis of latent TB. We aimed to (1) determine the proportion of HIV-1-infected adults with a negative QuantiFERON®-TB Gold in-tube (QFT-GIT) and ... Read more c b
Randomized placebo-controlled trial of prednisone for paradoxical tuberculosis-associated immune reconstitution inflammatory syndrome

Author: Meintjes, Graeme ; Wilkinson, Robert J ; Morroni, Chelsea ; Pepper, Dominique J ; Rebe, Kevin ; Rangaka, Molebogeng X ; Oni, Tolu ; Maartens, Gary Date: 2010 Objective: Paradoxical tuberculosis-associated immune reconstitution inflammatory syndrome (TB-IRIS) is a frequent complication of antiretroviral therapy in resource-limited countries. We aimed to assess whether a 4 week course of prednisone ... Read more

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