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Browsing by Author "Okpechi, Ikechi G"

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An African perspective on the genetic risk of chronic kidney disease: a systematic review

Author: George, Cindy ; Yako, Yandiswa Y ; Okpechi, Ikechi G ; Matsha, Tandi E ; Kaze Folefack, Francois J ; Kengne, Andre P Date: 19 Oct 2018 Background Individuals of African ethnicity are disproportionately burdened with chronic kidney disease (CKD). However, despite the genetic link, genetic association studies of CKD in African populations are lacking. ... Read more
Baseline predictors of mortality among predominantly rural-dwelling end-stage renal disease patients on chronic dialysis therapies in Limpopo, South Africa

Author: Isla, Ramon A Tamayo ; Ameh, Oluwatoyin I ; Mapiye, Darlington ; Swanepoel, Charles R ; Bello, Aminu K ; Ratsela, Andrew R ; Okpechi, Ikechi G Date: 2016 BACKGROUND: Dialysis therapy for end-stage renal disease (ESRD) continues to be the readily available renal replacement option in developing countries. While the impact of rural/remote dwelling on mortality among dialysis patients in developed ... Read more c b
Clinico-pathological correlation and outcome in patients with mesangioproliferative glomerulonephritis in Cape Town: A single centre study

Author: Barday, Zibya Date: 2018 Background Glomerulonephritis is a major cause of end-stage kidney disease (ESRD) in Africa. There is scanty data on the clinico-pathological characteristics and outcome of the mesangioproliferative glomerulonephritides in Africa, despite the ... Read more
Clinico-pathological features of repeat renal biopsies in patients with lupus nephritis at Groote Schuur Hospital, Cape Town

Author: Kajawo, Shepherd Date: 2017 Background: Repeat renal biopsies in patients with lupus nephritis (LN) are usually done to guide treatment or to establish disease chronicity. Their value is not clear from available literature. There is also no available data in Africa to ... Read more
Complications of percutaneous native kidney biopsies in adults in low and middle-income countries: A Systematic review and meta-analysis

Author: Kajawo, Shepherd Date: 2021 Introduction: Kidney biopsy supports diagnoses, choice of treatment and prognostication in management of kidney diseases. Complications associated with this procedure varies among countries depending on several clinical and technical factors. ... Read more
Diagnostic performance of glomerular PLA2R and THSD7A antibodies in biopsy confirmed primary membranous nephropathy in South Africans

Author: Lwezaula, Bingileki F ; Ameh, Oluwatoyin I ; Ekrikpo, Udeme E ; Botha, Francois C ; Okpechi-Samuel, Ugochi S ; Wearne, Nicola ; Ronco, Pierre ; Bello, Aminu K ; Okpechi, Ikechi G Date: 07 Jan 2021 Background: Serum and tissue-based tests using phospholipase A2 receptor 1 (PLA2R) and thrombospondin type-1 domain containing 7A (THSD7A) are established immune biomarkers for the diagnosis of primary membranous nephropathy (PMN). This study ... Read more
Epidemiology and clinical outcomes of patients with idiopathic membranous glomerulonephritis at Groote Schuur Hospital over a ten year period

Author: Ameh, Oluwatoyin Idaomeh Date: 2015 BACKGROUND: Glomerulonephritis is a common cause of end-stage renal disease (ESRD) in developing countries. Idiopathic membranous nephropathy (IMGN) is an identified cause of nephrotic syndrome in South Africa. Early attainment of complete ... Read more
Epidemiology of histologically proven Glomerulonephritis in Africa: A systematic review and meta-analysis

Author: Okpechi, Ikechi G ; Ameh, Oluwatoyin I ; Bello, Aminu K ; Ronco, Pierre ; Swanepoel, Charles R ; Kengne, Andre P Date: 2016 Background and aim: Glomerulonephritis (GN) is a leading cause of end-stage renal disease (ESRD) in Africa. Data on epidemiology and outcomes of glomerular diseases from Africa is still limited. We conducted a systematic review on the ... Read more c b
Genetic variation at selected SNPs in the leptin gene and association of alleles with markers of kidney disease in a Xhosa population of South Africa

Author: Okpechi, Ikechi G ; Rayner, Brian L ; van der Merwe, Lize ; Mayosi, Bongani M ; Adeyemo, Adebowale ; Tiffin, Nicki ; Ramesar, Rajkumar Date: 2010 BACKGROUND: Chronic kidney disease (CKD) is a significant public health problem that leads to end-stage renal disease (ESRD) with as many as 2 million people predicted to need therapy worldwide by 2010. Obesity is a risk factor for CKD and ... Read more c b
Outcome of patients with primary immune-complex type Mesangiocapillary Glomerulonephritis (MCGN) in Cape Town South Africa

Author: Okpechi, Ikechi G ; Dlamini, Thandiwe A L ; Duffield, Maureen ; Rayner, Brian L ; Moturi, George ; Swanepoel, Charles R Date: 2014 Background and Aim Mesangiocapillary glomerulonephritis (MCGN) is a common cause of chronic kidney disease in developing countries. Data on the renal outcome of patients with idiopathic MCGN is limited. The aim of this study is to investigate ... Read more c b
Outcomes of renal transplantation in patients with lupus nephritis: a single centre study in Cape Town

Author: Almradi, Ahmed Khalifa Mohamed Date: 2017 Background: Kidney disease (lupus nephritis [LN]) constitutes a feature of systemic lupus erythematosus (SLE) in up to 50 - 70% of patients with the disease. Although most LN patients are suitable for renal transplantation when they develop ... Read more
A practical approach to the nutritional management of chronic kidney disease patients in Cape Town, South Africa

Author: Ameh, Oluwatoyin I ; Cilliers, Lynette ; Okpechi, Ikechi G Date: 08 Jul 2016 Background: The multi-racial and multi-ethnic population of South Africa has significant variation in their nutritional habits with many black South Africans undergoing a nutritional transition to Western type diets. In this review, we describe ... Read more c b
Prevalence of polypharmacy and associated adverse health outcomes in adult patients with chronic kidney disease: protocol for a systematic review and meta-analysis

Author: Okpechi, Ikechi G ; Tinwala, Mohammed M ; Muneer, Shezel ; Zaidi, Deenaz ; Ye, Feng ; Hamonic, Laura N ; Khan, Maryam ; Sultana, Naima ; Brimble, Scott ; Grill, Allan ; Klarenbach, Scott ; Lindeman, Cliff ; Molnar, Amber ; Nitsch, Dorothea ; Ronksley, Paul ; Shojai, Soroush ; Soos, Boglarka ; Tangri, Navdeep ; Thompson, Stephanie ; Tuot, Delphine ; Drummond, Neil ; Mangin, Dee ; Bello, Aminu K Date: 04 Jul 2021 Background Polypharmacy, often defined as the concomitant use of ≥ 5 medications, has been identified as a significant global public health threat. Aging and multimorbidity are key drivers of polypharmacy and have been linked ... Read more c b
Standardised Outcomes in Nephrology – Chronic Kidney Disease (SONG-CKD): a protocol for establishing a core outcome set for adults with chronic kidney disease who do not require kidney replacement therapy

Author: Evangelidis, Nicole ; Sautenet, Benedicte ; Madero, Magdalena ; Tong, Allison ; Ashuntantang, Gloria ; Sanabria, Laura C ; de Boer, Ian H ; Fung, Samuel ; Gallego, Daniel ; Levey, Andrew S ; Levin, Adeera ; Lorca, Eduardo ; Okpechi, Ikechi G ; Rossignol, Patrick ; Sola, Laura ; Usherwood, Tim ; Wheeler, David C ; Cho, Yeoungjee ; Howell, Martin ; Guha, Chandana ; Scholes-Robertson, Nicole ; Widders, Katherine ; Gonzalez, Andrea M ; Teixeira-Pinto, Armando ; Viecelli, Andrea K ; Bernier-Jean, Amelie ; Anumudu, Samaya ; Dunn, Louese ; Wilkie, Martin ; Craig, Jonathan C Date: 09 Sep 2021 Background Globally, over 1.2 million people die from chronic kidney disease (CKD) every year. Patients with CKD are up to 10 times more likely to die prematurely than progress to kidney failure requiring kidney replacement ... Read more c b
The effects of add-on corticosteroids on renal outcomes in patients with biopsy proven HIV associated nephropathy: a single centre study from South Africa

Author: Wearne, Nicola ; Swanepoel, Charles R ; Duffield, Maureen S ; Davidson, Bianca J ; Manning, Kathryn ; Tiffin, Nicki ; Boulle, Andrew ; Rayner, Brian L ; Naidu, Priyanka ; Okpechi, Ikechi G Date: 06 Feb 2019 Background The aim of this study was to assess, the efficacy and safety of add-on corticosteroids to antiretroviral therapy [ART] in patients with biopsy proven HIV associated nephropathy. ... Read more

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Browsing by Author "Okpechi, Ikechi G"

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