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Browsing by Author "Ntsekhe, Mpiko"

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Achievement of secondary prevention goals 6 to 9 months after Acute Coronary Syndrome : a retrospective, cross-sectional analysis

Author: Griffiths, Bradley Paul Date: 2014 Study Rationale: Good evidence exists to support the use of secondary prevention medications (aspirin, HMG-CoA reductase inhibitors [statins], beta-blockers and angiotensin-converting enzyme inhibitors [ACEIs] or angiotensin receptor blockers ... Read more
Advancing global health through cardiovascular research, mentorship, and capacity building: in memoriam, professor Bongani Mayosi (1967–2018)

Author: Nachega, Jean B ; Ntsekhe, Mpiko ; Volmink, Jimmy ; Thabane, Lehana Date: 03 Oct 2018 We are deeply saddened by the passing of Professor Bongani Mayosi. Bongani was one of the inaugural board members of Pilot and Feasibility Studies. He contributed greatly to the design and conduct of pilot and feasibility studies in cardiovascular ... Read more
Cardio-thoracic ratio is stable, reproducible and has potential as a screening tool for HIV-1 related cardiac disorders in resource poor settings

Author: Esmail, Hanif ; Oni, Tolu ; Thienemann, Friedrich ; Omar-Davies, Nashreen ; Wilkinson, Robert J ; Ntsekhe, Mpiko Date: 2016 BACKGROUND: Cardiovascular disorders are common in HIV-1 infected persons in Africa and presentation is often insidious. Development of screening algorithms for cardiovascular disorders appropriate to a resource-constrained setting could ... Read more c b
Clinical characteristics and initial management of patients with tuberculous pericarditis in the HIV era: the Investigation of the Management of Pericarditis in Africa (IMPI Africa) registry

Author: Mayosi, Bongani ; Wiysonge, Charles ; Ntsekhe, Mpiko ; Volmink, Jimmy ; Gumedze, Freedom ; Maartens, Gary ; Aje, Akinyemi ; Thomas, Baby ; Thomas, Kandathil ; Awotedu, Abolade ; Thembela, Bongani ; Mntla, Phindile ; Maritz, Frans ; Blackett, Kathleen ; Nkouonlack, Date: 2006 BACKGROUND:The incidence of tuberculous pericarditis has increased in Africa as a result of the human immunodeficiency virus (HIV) epidemic. However, the effect of HIV co-infection on clinical features and prognosis in tuberculous pericarditis ... Read more c b
Clinical profiles and outcomes of patients receiving acute renal replacement therapy in the cardiac intensive care unit at a South African tertiary centre

Author: Mbanga, Luyanda C Date: 2022 Background At least a quarter of patients admitted to the Cardiac Intensive Care Unit (CICU) will develop Acute Kidney Injury (AKI) and some of these patients receive Renal Replacement Therapy (RRT). The clinical profiles and outcomes of CICU ... Read more
Development of a risk score for constrictive pericarditis using the Investigation of the Management of Pericarditis randomised clinical trial dataset

Author: Geffen, Hayli Date: 2022 Despite the recent global decline of tuberculosis infections, constrictive pericarditis, one of the most serious consequences of tuberculous pericarditis, continues to be a major cause of morbidity and mortality in sub-Saharan Africa. Currently, ... Read more
Diagnostic accuracy of quantitative PCR (Xpert MTB/RIF) for tuberculous pericarditis compared to adenosine deaminase and unstimulated interferon-γ in a high burden setting: a prospective study

Author: Pandie, Shaheen ; Peter, Jonathan G ; Kerbelker, Zita S ; Meldau, Richard ; Theron, Grant ; Govender, Ureshnie ; Ntsekhe, Mpiko ; Dheda, Keertan ; Mayosi, Bongani M Date: 18 Jun 2014 Background: Tuberculous pericarditis (TBP) is associated with high morbidity and mortality, and is an important treatable cause of heart failure in developing countries. Tuberculous aetiology of pericarditis is difficult to diagnose promptly. ... Read more
Diagnostic utility of pericardial fluid pH in diagnosing infectious pericardial effusions among patients with moderate and large effusions undergoing pericardiocentesis at Groote Schuur Hospital: a subs-study of the IMPI trial

Author: Kiggundu, Brian Date: 2020 Diagnosis of infectious pericardial disease has been challenging in the developing world despite improvement of treatment modalities. The diagnostic utility of pH in diagnosing infectious pericardial fluid is unknown, yet this concept is well ... Read more
HIV infection is associated with a lower incidence of constriction in presumed tuberculous pericarditis: a prospective observational study

Author: Ntsekhe, Mpiko ; Wiysonge, Charles S ; Gumedze, Freedom ; Maartens, Gary ; Commerford, Patrick J ; Volmink, Jimmy A ; Mayosi, Bongani M Date: 2008 BACKGROUND: Pericardial constriction is a serious complication of tuberculous pericardial effusion that occurs in up to a quarter of patients despite anti-tuberculosis chemotherapy. The impact of human immunodeficiency virus (HIV) infection ... Read more c b
International normalised ratio control in a non-metropolitan setting in Western Cape Province, South Africa

Author: Prinsloo, Dawid Nicolaas Date: 2021 Background: The quality of INR control determines the effectiveness and safety of Warfarin. Data on INR control in non-metropolitan settings of South Africa (SA) is sparse. Objectives: To examine the Time in Therapeutic Range (TTR) and its ... Read more
The investigation of the management of pericarditis in Africa (IMPI Africa) project : rationalé, design, baseline characteristics and mortality in a multinational registry of suspected tuberculous pericarditis

Author: Ntsekhe, Mpiko Date: 2006 Includes bibliographical references. Read more
Investigation of the management of tuberculous pericarditis (IMPI) registry : survival and outcomes sub-study

Author: Mubanga, Mwenya Date: 2012 Includes abstract. Includes bibliographical references. Read more
Mortality in patients treated for tuberculous pericarditis in sub-Saharan Africa.

Author: Mayosi, Bongani M ; Wiysonge, Charles Shey ; Ntsekhe, Mpiko ; Gumedze, Freedom ; Volmink Jimmy A ; Maartens, Gary ; Aje, Akinyemi ; Thomas, Baby M ; Thomas, Kandathil M ; Awotedu, Abolade A ; Bongani, Thembela ; Mntla, Phindile ; Maritz, Frans ; Blackett, Kathleen Ngu ; Nkouonlack, Duquesne C ; Burch, Vanessa C ; Rebe, Kevin ; Parrish, Andy ; Sliwa, Karen ; Vezi, Brian Z ; Alam, Nowshad ; Brown, Basil G ; Gould, Trevor ; Visser, Tim ; Magula, Nombulelo P ; Commerford, Patrick J Date: 2008 Tuberculous pericarditis is one of the most severe forms of extrapulmonary tuberculosis, causing death or disability in a substantial proportion of affected people.1,2 In Africa, the incidence of tuberculous pericarditis is rising as a result ... Read more
Prevalence, hemodynamics, and cytokine profile of effusive-constrictive pericarditis in patients with tuberculous pericardial effusion

Author: Ntsekhe, Mpiko ; Matthews, Kerryn ; Syed, Faisal F ; Deffur, Armin ; Badri, Motasim ; Commerford, Patrick J ; Gersh, Bernard J ; Wilkinson, Katalin A ; Wilkinson, Robert J ; Mayosi, Bongani M Date: 2013 BACKGROUND: Effusive constrictive pericarditis (ECP) is visceral constriction in conjunction with compressive pericardial effusion. The prevalence of proven tuberculous ECP is unknown. Whilst ECP is distinguished from effusive disease on ... Read more c b
Profile, Presentation and Outcomes of Prosthetic Valve Endocarditis in a South African Tertiary Hospital: Insights From the Groote Schuur Hospital Infective Endocarditis Registry

Author: Mkoko, Philasande Date: 2022 Background Prosthetic valve infective endocarditis (PVE) is associated with high morbidity and mortality. The prevalence of PVE in local retrospective studies ranges between 13% and 16%. However, the clinical patient profile and outcomes ... Read more
Quantification of echodensities in tuberculous pericardial effusion using fractal geometry: a proof of concept study

Author: Ntsekhe, Mpiko ; Mayosi, Bongani ; Gumbo, Tawanda Date: 2012 BACKGROUND:The purpose of this study was to quantify the heterogeneous distribution of echodensities in the pericardial fluid of patients with tuberculous pericarditis using echocardiography and fractal analysis, and to determine whether there ... Read more c b
Studies of effusive constrictive pericarditis

Author: Ntsekhe, Mpiko Date: 2011 Tuberculous (TB) pericarditis is associated with a mortality rate of 17-40% despite treatment with anti-tuberculosis drugs. The complications of TB pericarditis that confer mortality and morbidity are pericardial tamponade, effusive constrictive ... Read more
The changing landscape of infective endocarditis in South Africa

Author: de Villiers, Marthinus Coenraad Date: 2019 Background. Little is known about the current clinical profile and outcomes of patients with infective endocarditis (IE) in South Africa. Methods. We conducted a retrospective review of the records of patients admitted to Groote Schuur Hospital ... Read more
The impact of HIV on 30-day survival amongst patients undergoing cardiac surgery at Groote Schuur Hospital in the ART era

Author: Boloko, Linda Date: 2020 Introduction: The impact of HIV on the one-month perioperative morbidity and mortality in patients undergoing cardiac surgery in sub-Saharan Africa (SSA) in the AntiRetroviral Therapy (ART) era is not known. Pre ART era data from South Africa ... Read more
The prevalence, profile, and prognosis of heart failure with preserved ejection fraction: A South African tertiary hospital experience

Author: Nshuti, Shema David Date: 2022 Background. There is limited data on heart failure with preserved ejection fraction (HFpEF) in Sub-Saharan Africa. We therefore aimed to describe the prevalence, profile and outcomes of HFpEF patients admitted to a South African tertiary ... Read more

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