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Browsing by Author "Njoroge, Mathew"

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In vitro metabolism of tetrazole aminoquinolines and derivatives of metergoline and fusidic acid

Author: Njoroge, Mathew Date: 2014 Drug metabolism is recognised as a key component of the drug discovery and development process. It exerts an influence on the action, duration of action and toxicity of a drug in vivo. The integration of drug metabolism studies is therefore ... Read more
Synthesis and In Vitro Antiprotozoan Evaluation of 4-/8-Aminoquinoline-based Lactams and Tetrazoles

Author: Tukulula, Matshawandile ; Louw, Stefan ; Njoroge, Mathew ; Chibale, Kelly Date: 15 Dec 2020 A second generation of 4-aminoquinoline- and 8-aminoquinoline-based tetrazoles and lactams were synthesized via the Staudinger and Ugi multicomponent reactions. These compounds were subsequently evaluated in vitro for their potential ... Read more c b
Total Synthesis of the Antimycobacterial Natural Product Chlorflavonin and Analogs via a Late-Stage Ruthenium(II)-Catalyzed ortho-C(sp2)-H-Hydroxylation

Author: Berger, Alexander ; Knak, Talea ; Kiffe-Delf, Anna-Lene ; Mudrovcic, Korana ; Singh, Vinayak ; Njoroge, Mathew ; Burckhardt, Bjoern B. ; Gopalswamy, Mohanraj ; Lungerich, Beate ; Ackermann, Lutz ; Gohlke, Holger ; Chibale, Kelly ; Kalscheuer, Rainer ; Kurz, Thomas Date: 10 Aug 2022 The continuous, worldwide spread of multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis (TB) endanger the World Health Organization’s (WHO) goal to end the global TB pandemic by the year 2035. During the past 50 ... Read more c b

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Browsing by Author "Njoroge, Mathew"

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