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Browsing by Author "Nicol, Mark P"

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Azithromycin versus placebo for the treatment of HIV-associated chronic lung disease in children and adolescents (BREATHE trial): study protocol for a randomised controlled trial

Author: Gonzalez-Martinez, Carmen ; Kranzer, Katharina ; McHugh, Grace ; Corbett, Elizabeth L ; Mujuru, Hilda ; Nicol, Mark P ; Rowland-Jones, Sarah ; Rehman, Andrea M ; Gutteberg, Tore J ; Flaegstad, Trond ; Odland, Jon O ; Ferrand, Rashida A Date: 28 Dec 2017 Background: Human immunodeficiency virus (HIV)-related chronic lung disease (CLD) among children is associated with substantial morbidity, despite antiretroviral therapy. This may be a consequence of repeated respiratory tract infections ... Read more c b
Characterisation of STEC and other diarrheic E. coli isolated on CHROMagar™STEC at a tertiary referral hospital, Cape Town

Author: Kalule, John B ; Keddy, Karen H ; Nicol, Mark P Date: 08 Jun 2018 Abstract Background Shiga toxin producing E. coli (STEC) is an emerging zoonotic pathogen that can cause acute renal failure, especially in children. Clinical microbiology laboratories may ... Read more
Characterization of Mycobacterium tuberculosis isolates with discordant rifampicin susceptibility test results

Author: Ghebrekristos, Yonas Date: 2018 Background: The Xpert MTB/RIF assay was adopted as the initial diagnostic test for patients with presumptive tuberculosis (TB) by the South African National TB Control programme in December 2010. Rifampicin (RIF) resistance detected by the ... Read more
Comparison of a real-time multiplex PCR and sequetyping assay for pneumococcal serotyping

Author: Dube, Felix S ; van Mens, Suzan P ; Robberts, Lourens ; Wolter, Nicole ; Nicol, Paul ; Mafofo, Joseph ; Africa, Samantha ; Zar, Heather J ; Nicol, Mark P Date: 2015 BACKGROUND: Pneumococcal serotype identification is essential to monitor pneumococcal vaccine effectiveness and serotype replacement. Serotyping by conventional serological methods are costly, labour-intensive, and require significant technical ... Read more c b
Correction to: Diagnostic accuracy of the Xpert MTB/Rif Ultra for tuberculosis adenitis

Author: Antel, Katherine ; Oosthuizen, Jenna ; Malherbe, Francois ; Louw, Vernon J ; Nicol, Mark P ; Maartens, Gary ; Verburgh, Estelle Date: 02 Mar 2020 After publication of the original article [1], we were notified that there is a mistake in the article note. Read more c b
Detection of Streptococcus pneumoniae from different types of nasopharyngeal swabs in children

Author: Dube, Felix S ; Kaba, Mamadou ; Whittaker, Elizabeth ; Zar, Heather J ; Nicol, Mark P Date: 2013 BACKGROUND: A better understanding of the epidemiology of nasopharyngeal carriage of Streptococcus pneumoniae is important to assess the impact of vaccination and the pathogenesis of pneumococcal disease. We compared the recovery of S. ... Read more c b
Diagnostic accuracy of the Xpert MTB/Rif Ultra for tuberculosis adenitis

Author: Antel, Katherine ; Oosthuizen, Jenna ; Malherbe, Francois ; Louw, Vernon J ; Nicol, Mark P ; Maartens, Gary ; Verburgh, Estelle Date: 13 Jan 2020 Abstract Background The WHO recently recommended the new Xpert MTB/RIF Ultra assay (Ultra) instead of the Xpert MTB/RIF assay because Ultra has improved sensitivity. We report the diagnostic accuracy of Ultra for tuberculous adenitis in a ... Read more
Impact of Xpert MTB/RIF for TB diagnosis in a primary care clinic with high TB and HIV prevalence in South Africa: a pragmatic randomised trial

Author: Cox, Helen S ; Mbhele, Slindile ; Mohess, Neisha ; Whitelaw, Andrew ; Muller, Odelia ; Zemanay, Widaad ; Little, Francesca ; Azevedo, Virginia ; Simpson, John ; Boehme, Catharina C ; Nicol, Mark P Date: 2014 Background: Xpert MTB/RIF is approved for use in tuberculosis (TB) and rifampicin-resistance diagnosis. However, data are limited on the impact of Xpert under routine conditions in settings with high TB burden. Methods and Findings: A pragmatic ... Read more c b
Improving point-of-care diagnosis of tuberculosis: development and evaluation of novel technologies

Author: Moodley, Vineshree Mischka Date: 2017 With an estimated third of all tuberculosis (TB) cases being missed, the need to develop rapid, simple and accurate diagnostic tests is critical. The last five years has seen an unprecedented activity in the development of a range of new ... Read more
Modern lineages of Mycobacterium tuberculosis exhibit lineage-specific patterns of growth and cytokine induction in human monocyte-derived macrophages

Author: Sarkar, Rajesh ; Lenders, Laura ; Wilkinson, Katalin A ; Wilkinson, Robert J ; Nicol, Mark P Date: 2012 BACKGROUND: Strains of Mycobacterium tuberculosis vary in virulence. Strains that have caused outbreaks in the United States and United Kingdom have been shown to subvert the innate immune response as a potential immune evasion mechanism. ... Read more c b
Molecular epidemiology of Staphylococcus aureus in African children from rural and urban communities with atopic dermatitis

Author: Ndhlovu, Gillian O N ; Abotsi, Regina E ; Shittu, Adebayo O ; Abdulgader, Shima M ; Jamrozy, Dorota ; Dupont, Christopher L ; Mankahla, Avumile ; Nicol, Mark P ; Hlela, Carol ; Levin, Michael E ; Lunjani, Nonhlanhla ; Dube, Felix S Date: 13 Apr 2021 Abstract Background Staphylococcus aureus has been associated with the exacerbation and severity of atopic dermatitis (AD). Studies have not investigated the colonisation dynamics of S. aureus ... Read more
One Health-One City; the extent of Shiga-toxin producing Escherichia coli in Cape Town

Author: Kalule, John Bosco Date: 2017 The estimated global burden of STEC (Shiga toxin producing Escherichia coli) is 2,481,511 illnesses, 269 deaths, and 26,827 DALYs with 48% of these being foodborne. This thesis provides information on STEC diagnostic strategy, undetected STEC ... Read more
Optimizing 16S rRNA gene profile analysis from low biomass nasopharyngeal and induced sputum specimens

Author: Claassen-Weitz, Shantelle ; Gardner-Lubbe, Sugnet ; Mwaikono, Kilaza S ; du Toit, Elloise ; Zar, Heather J ; Nicol, Mark P Date: 12 May 2020 Careful consideration of experimental artefacts is required in order to successfully apply high-throughput 16S ribosomal ribonucleic acid (rRNA) gene sequencing technology. Here we introduce experimental design, quality control and “denoising” ... Read more
Outbreak of multi-drug resistant Pseudomonas aeruginosa bloodstream infection in the haematology unit of a South African academic hospital

Author: Mudau, Maanda ; Jacobson, Rachael ; Minenza, Nadia ; Kuonza, Lazarus ; Morris, Vida ; Engelbrecht, Heather ; Nicol, Mark P ; Bamford, Colleen Date: 2013 Objective: To describe an outbreak of multi-resistant Pseudomonas aeruginosa bloodstream infections (MRPA-BSI) that occurred in the haematology ward of a tertiary academic hospital in Cape Town, South Africa, and determine risk factors for ... Read more c b
Prevalence and antibiotic susceptibility patterns of enteric bacterial pathogens in human and non-human sources in an urban informal settlement in Cape Town, South Africa

Author: Kalule, John B ; Smith, Anthony M ; Vulindhlu, Mjikisile ; Tau, Nomsa P ; Nicol, Mark P ; Keddy, Karen H ; Robberts, Lourens Date: 06 Nov 2019 Abstract Background In light of rampant childhood diarrhoea, this study investigated bacterial pathogens from human and non-human sources in an urban informal settlement. Meat ... Read more
Prevalence and antimicrobial resistance profiles of respiratory microbial flora in African children with HIV-associated chronic lung disease

Author: Abotsi, Regina E ; Nicol, Mark P ; McHugh, Grace ; Simms, Victoria ; Rehman, Andrea M ; Barthus, Charmaine ; Mbhele, Slindile ; Moyo, Brewster W ; Ngwira, Lucky G ; Mujuru, Hilda ; Makamure, Beauty ; Mayini, Justin ; Odland, Jon Ø ; Ferrand, Rashida A ; Dube, Felix S Date: 25 Feb 2021 Background HIV-associated chronic lung disease (CLD) is common among children living with HIV (CLWH) in sub-Saharan Africa, including those on antiretroviral therapy (ART). However, the pathogenesis of CLD and its possible ... Read more c b
Rapid diagnosis of tuberculosis with the Xpert MTB/RIF assay in high burden countries: a cost-effectiveness analysis

Author: Vassall, Anna ; van Kampen, Sanne ; Sohn, Hojoon ; Michael, Joy S ; John, K R ; den Boon, Saskia ; Davis, J Lucian ; Whitelaw, Andrew ; Nicol, Mark P ; Gler, Maria Tarcela ; Khaliqov, Anar ; Zamudio, Carlos ; Perkins, Mark D ; Boehme, Catharina C ; Cobelens, Frank Date: 2011 Background: Xpert MTB/RIF (Xpert) is a promising new rapid diagnostic technology for tuberculosis (TB) that has characteristics that suggest large-scale roll-out. However, because the test is expensive, there are concerns among TB program ... Read more c b
Respiratory microbes present in the nasopharynx of children hospitalised with suspected pulmonary tuberculosis in Cape Town, South Africa

Author: Dube, Felix S ; Kaba, Mamadou ; Robberts, F J Lourens ; Tow, Lemese A ; Lubbe, Sugnet ; Zar, Heather J ; Nicol, Mark P Date: 24 Oct 2016 Background: Lower respiratory tract infection in children is increasingly thought to be polymicrobial in origin. Children with symptoms suggestive of pulmonary tuberculosis (PTB) may have tuberculosis, other respiratory tract infections or ... Read more c b
Screening for HIV-associated tuberculosis and rifampicin resistance before antiretroviral therapy using the Xpert MTB/RIF assay: a prospective study

Author: Lawn, Stephen D ; Brooks, Sophie V ; Kranzer, Katharina ; Nicol, Mark P ; Whitelaw, Andrew ; Vogt, Monica ; Bekker, Linda-Gail ; Wood, Robin Date: 2011 Background: The World Health Organization has endorsed the Xpert MTB/RIF assay for investigation of patients suspected of having tuberculosis (TB). However, its utility for routine TB screening and detection of rifampicin resistance among ... Read more c b

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Browsing by Author "Nicol, Mark P"

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