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Browsing by Author "Nicol, Mark"

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“A very humiliating illness”: a qualitative study of patient-centered Care for Rifampicin-Resistant Tuberculosis in South Africa

Author: Furin, Jennifer ; Loveday, Marian ; Hlangu, Sindisiwe ; Dickson-Hall, Lindy ; le Roux, Sacha ; Nicol, Mark ; Cox, Helen Date: 17 Jan 2020 Abstract Background Patient-centered care is pillar 1 of the “End TB” strategy, but little has been documented in the literature about what this means for people living with rifampicin-resistant (RR-TB). Optimizing care for such individuals ... Read more
Ambulatory and hospitalized childhood pneumonia: a longitudinal study in a peri-urban low-income community with high vaccination coverage in Sub-Saharan Africa

Author: le Roux, David Date: 2022 Background Child pneumonia is a substantial cause of childhood mortality and morbidity; it is the largest single cause of under-5 mortality outside the neonatal period. Incidence of child pneumonia, and pneumonia mortality, have decreased ... Read more
Determine TB-LAM lateral flow urine antigen assay for HIV-associated tuberculosis: recommendations on the design and reporting of clinical studies

Author: Lawn, Stephen ; Dheda, Keertan ; Kerkhoff, Andrew ; Peter, Jonathan ; Dorman, Susan ; Boehme, Catharina ; Nicol, Mark Date: 2013 Detection of the Mycobacterium tuberculosis cell wall antigen lipoarabinomannan (LAM) in urine permits diagnoses of tuberculosis (TB) to be made in HIV-infected patients with advanced immunodeficiency. This can be achieved at the point-of-care ... Read more c b
Dynamics of faecal bacterial populations in early infancy as determined by massively parallel sequencing

Author: Claassen, Shantelle Date: 2015 Background: Meconium microbiota have recently gained great interest; however very few studies have included meconium specimens when longitudinally characterizing the infant GIT microbiota. This study therefore aimed to longitudinally characterize ... Read more
Epidemiology of extended spectrum beta-lactamase and carbapenemase-producing bacteria in stool from apparently healthy children, South Africa

Author: Manenzhe, Rendani Innocent Date: 2015 Background: The prevalence of extended-spectrum beta-lactamase (ESBL) - and carbapenemase-producing Enterobacteriaceae in healthy humans in the community is largely unknown. We aimed to determine the prevalence and genetic characteristics of ... Read more
High levels of multidrug resistant tuberculosis in new and treatment-failure patients from the Revised National Tuberculosis Control Programme in an urban metropolis (Mumbai) in Western India

Author: D'souza, Desiree TB ; Mistry, Nerges F ; Vira, Tina N ; Dholakia, Yatin ; Hoffner, Sven ; Pasvol, Geoffrey ; Nicol, Mark ; Wilkinson, Robert J Date: 2009 BACKGROUND: India, China and Russia account for more than 62% of multidrug resistant tuberculosis (MDRTB) globally. Within India, locations like urban metropolitan Mumbai with its burgeoning population and high incidence of TB are suspected ... Read more c b
The house dust microbiota in the Drakenstein Child Health Study

Author: Duyver, Menna Date: 2015 Introduction: The indoor home environment comprises many niches that are occupied by bacterial communities. The composition of these bacterial communities may be influenced by numerous factors such as number of occupants, pets, season and ... Read more
Impact of a novel molecular TB diagnostic system in patients at high risk of TB mortality in rural South Africa (Uchwepheshe): study protocol for a cluster randomised trial

Author: Lessells, Richard ; Cooke, Graham ; McGrath, Nuala ; Nicol, Mark ; Newell, Marie-Louise ; Godfrey-Faussett, Peter Date: 2013 BACKGROUND: Tuberculosis control in sub-Saharan Africa has long been hampered by poor diagnostics and weak health systems. New molecular diagnostics, such as the Xpert(R) MTB/RIF assay, have the potential to improve patient outcomes. We present ... Read more c b
The innate immune response to Mycobacterium tuberculosis is dependent on strain lineage and on host population

Author: Sarkar, Rajesh Date: 2013 The genome structure of Mycobacterium tuberculosis is strongly clonal, in the absence of horizontal gene transfer. Thus it is feasible that clonal lineages may exhibit particular phenotypic characteristics, which may, in turn, result in ... Read more
Nasopharyngeal colonization dynamics with Streptococcus pneumoniae and associated antimicrobial resistance in a South African birth cohort

Author: Manenzhe, Rendani Innocent Date: 2019 Introduction: Nasopharyngeal (NP) colonization by Streptococcus pneumoniae (the pneumococcus) precedes the development of respiratory tract infection. Colonization by antimicrobial-resistant pneumococci, especially in infants, is a major ... Read more
Novel Diagnostic approach for tuberculosis diagnosis

Author: Milovic, Ana Date: 2010 There is a clear need for a rapid, inexpensive point-of-care diagnostic test for tuberculosis (TB). The aim of this study was to analyze the performance of a novel rapid diagnostic test for TB, GeneXpert MTB/RIF, in symptomatic adults and to ... Read more
Reversion and conversion of Mycobacterium tuberculosis IFN-gamma ELISpot results during anti-tuberculous treatment in HIV-infected children

Author: Connell, Tom ; Davies, Mary-Ann ; Johannisen, Christine ; Wood, Kathryn ; Pienaar, Sandy ; Wilkinson, Katalin ; Wilkinson, Robert ; Zar, Heather ; Beatty, David ; Nicol, Mark ; Curtis, Nigel ; Eley, Brian Date: 2010 BACKGROUND: Recent interest has focused on the potential use of serial interferon gamma (IFN-gamma) release assay (IGRA) measurements to assess the response to anti-tuberculous (TB) treatment. The kinetics of IFN-gamma responses to Mycobacterium ... Read more c b
The bacteriome and metabolome of human breast milk and their association with infant growth

Author: Ojo, Anna Olutoyin Date: 2019 Human breast milk is a complex species-specific biological fluid universally known as the optimal postnatal source of nutrition for infants and therefore, recommended by the World Health Organization as the exclusive food for infants in the ... Read more

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