Browsing by Author "Negroni, Matteo"

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Molecular mechanisms of recombination restriction in the envelope gene of the human immunodeficiency virus

Author: Simon-Loriere, Etienne ; Galetto, Roman ; Hamoudi, Meriem ; Archer, John ; Lefeuvre, Pierre ; Martin, Darren P ; Robertson, David L ; Negroni, Matteo Date: 2009 Author Summary Recombination allows mixing portions of genomes of different origins, generating chimeric genes and genomes. With respect to the random generation of new mutations, it can lead to the simultaneous insertion of several substitutions, ... Read more c b
Potent sensitisation of cancer cells to anticancer drugs by a quadruple mutant of the human deoxycytidine kinase

Author: Coulibaly, Safiatou T ; Rossolillo, Paola ; Winter, Flore ; Kretzschmar, Franziska K ; Brayé, Mélanie ; Martin, Darren P ; Lener, Daniela ; Negroni, Matteo Date: 2015 Identifying enzymes that, once introduced in cancer cells, lead to an increased efficiency of treatment constitutes an important goal for biomedical applications. Using an original procedure whereby mutant genes are generated based on the use ... Read more c b

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