Browsing by Author "Moyo, Thandeka"

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Chinks in the armor of the HIV-1 Envelope glycan shield: implications for immune escape from anti-glycan broadly neutralizing antibodies

Author: Moyo, Thandeka ; Ferreira, Roux-cil ; Davids, Reyaaz ; Sonday, Zarinah ; Moore, Penny L ; Travers, Simon A ; Wood, Natasha T ; Dorfman, Jeffrey Robert Date: 15 Jan 2017 Glycans on HIV-1 Envelope serve multiple functions including blocking epitopes from antibodies. We show that removal of glycan 301, a major target of anti-V3/glycan antibodies, has substantially different effects in two viruses. While glycan ... Read more
Role of envelope compactness and glycosylation in HIV-1 resistance to neutralising antibody responses

Author: Moyo, Thandeka Date: 2017 Understanding the mechanisms used by HIV-1 to evade antibody neutralisation may contribute to the design of a high-coverage vaccine. This thesis explores the mechanism used by a Tier 3 virus leading to its high antibody neutralisation resistance ... Read more
The screening of neutralising antibodies against a resistant HIV-1 strain to identify novel epitopes

Author: Moyo, Thandeka Date: 2014 Since the start of the HIV/AIDS pandemic in the 1980s, over 75 million individuals have been infected with the virus and it has been the cause of approximately 36 million deaths worldwide. With such a high morbidity and mortality in HIV-1 ... Read more

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