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Browsing by Author "Morris, Lynn"

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Establishing a cohort at high risk of HIV infection in South Africa: challenges and experiences of the CAPRISA 002 acute infection study

Author: van Loggerenberg, Francois ; Mlisana, Koleka ; Williamson, Carolyn ; Auld, Sara C ; Morris, Lynn ; Gray, Clive M ; Karim, Quarraisha Abdool ; Grobler, Anneke ; Barnabas, Nomampondo ; Iriogbe, Itua Date: 2008 Objectives To describe the baseline demographic data, clinical characteristics and HIV-incidence rates of a cohort at high risk for HIV infection in South Africa as well as the challenges experienced in establishing and maintaining the cohort. ... Read more c b
Features of recently transmitted HIV-1 clade C viruses that impact antibody recognition: implications for active and passive immunization

Author: Rademeyer, Cecilia ; Korber, Bette ; Seaman, Michael S ; Giorgi, Elena E ; Thebus, Ruwayhida ; Robles, Alexander ; Sheward, Daniel J ; Wagh, Kshitij ; Garrity, Jetta ; Carey, Brittany R ; Gao, Hongmei ; Greene, Kelli M ; Tang, Haili ; Bandawe, Gama P ; Marais, Jinny C ; Diphoko, Thabo E ; Hraber, Peter ; Tumba, Nancy ; Moore, Penny L ; Gray, Glenda E ; Kublin, James ; McElrath, M Juliana ; Vermeulen, Marion ; Middelkoop, Keren ; Bekker, Linda-Gail ; Hoelscher, Michael ; Maboko, Leonard ; Makhema, Joseph ; Robb, Merlin L ; Karim, Salim Abdool ; Karim, Quarraisha Abdool ; Kim, Jerome H ; Hahn, Beatrice H ; Gao, Feng ; Swanstrom, Ronald ; Morris, Lynn ; Montefiori, David C ; Williamson, Carolyn Date: 2016 Author Summary: Vaccine and passive immunization prophylactic trials that rely on antibody-mediated protection are planned for HIV-1 clade C epidemic regions of southern Africa, which have amongst the highest HIV-1 incidences globally. This ... Read more c b
HIV-1 subtype C unproductively infects human cardiomyocytes in vitro and induces apoptosis mitigated by an anti-gp120 aptamer

Author: de Campos, Walter R Lopes ; Chirwa, Nthato ; London, Grace ; Rotherham, Lia S ; Morris, Lynn ; Mayosi, Bongani M ; Khati, Makobetsa Date: 2014 HIV-associated cardiomyopathy (HIVCM) is of clinical concern in developing countries because of a high HIV-1 prevalence, especially subtype C, and limited access to highly active antiretroviral therapy (HAART). For these reasons, we investigated ... Read more c b
Infection of Chinese Rhesus Monkeys with a Subtype C SHIV Resulted in Attenuated In Vivo Viral Replication Despite Successful Animal-to-Animal Serial Passages

Author: Chege, Gerald K ; Adams, Craig H ; Keyser, Alana T ; Bekker, Valerie ; Morris, Lynn ; Villinger, Francois J ; Williamson, Anna-Lise ; Chapman, Rosamund E Date: 02 Mar 2021 Rhesus macaques can be readily infected with chimeric simian-human immunodeficiency viruses (SHIV) as a suitable virus challenge system for testing the efficacy of HIV vaccines. Three Chinese-origin rhesus macaques (ChRM) were inoculated ... Read more
Optimal combinations of broadly neutralizing antibodies for prevention and treatment of HIV-1 Clade C infection

Author: Wagh, Kshitij ; Bhattacharya, Tanmoy ; Williamson, Carolyn ; Robles, Alex ; Bayne, Madeleine ; Garrity, Jetta ; Rist, Michael ; Rademeyer, Cecilia ; Yoon, Hyejin ; Lapedes, Alan ; Gao, Hongmei ; Greene, Kelli ; Louder, Mark K ; Kong, Rui ; Karim, Salim Abdool ; Burton, Dennis R ; Barouch, Dan H ; Nussenzweig, Michel C ; Mascola, John R ; Morris, Lynn ; Montefiori, David C ; Korber, Bette ; Seaman, Michael S Date: 2016 Author Summary In recent years, a new generation of monoclonal antibodies has been isolated from HIV-1 infected individuals that exhibit broad and potent neutralizing activity when tested against diverse strains of virus. There is a high level ... Read more c b
Prevalence of HIV-1 drug resistance amongst newly diagnosed HIV-infected infants age 4–8 weeks, enrolled in three nationally representative PMTCT effectiveness surveys, South Africa: 2010, 2011–12 and 2012–13

Author: Hunt, Gillian M ; Ledwaba, Johanna ; Salimo, Anna ; Kalimashe, Monalisa ; Dinh, Thu-Ha ; Jackson, Debra ; Sherman, Gayle ; Puren, Adrian ; Ngandu, Nobubelo K ; Lombard, Carl ; Morris, Lynn ; Goga, Ameena Date: 16 Sep 2019 Abstract Background South Africa (SA) has expanded efforts to reduce mother-to-child transmission of HIV (MTCT) to less than 2% at six weeks after birth and to less than 5% at 18 months postpartum ... Read more
Sequential Immunization with gp140 boosts immune responses primed by modified vaccinia Ankara or DNA in HIV-uninfected South African participants

Author: Churchyard, Gavin ; Mlisana, Koleka ; Karuna, Shelly ; Williamson, Anna-Lise ; Williamson, Carolyn ; Morris, Lynn ; Tomaras, Georgia D ; De Rosa, Stephen C ; Gilbert, Peter B ; Gu, Niya ; Yu, Chenchen ; Mkhize, Nonhlanhla N ; Hermanus, Tandile ; Allen, Mary ; Pensiero, Michael ; Barnett, Susan W ; Gray, Glenda ; Bekker, Linda-Gail ; Montefiori, David C ; Kublin, James ; Corey, Lawrence Date: 2016 BACKGROUND: The safety and immunogenicity of SAAVI DNA-C2 (4 mg IM), SAAVI MVA-C (2.9 x 10 9 pfu IM) and Novartis V2-deleted subtype C gp140 (100 mcg) with MF59 adjuvant in various vaccination regimens was evaluated in HIV-uninfected adults ... Read more c b
Studies on multiply exposed but persistently HIV-1 seronegative sex workers from KwaZulu/Natal, South Africa

Author: Malaza, Abraham Lucky Date: 2002 The overall aim of this study was to determine whether host genetic factors are associated with resistance to HIV-1 infection in a group of highly exposed persistently seronegative sex workers from KwaZulu/Natal, South Africa. A cohort of 17 ... Read more
Understanding the interplay between HIV-1 diversity, humoral immune responses and viral fitness

Author: Bandawe, Gama Petulo Date: 2014 HIV-1 antibody dependent cell cytotoxicity (ADCC) and neutralizing antibody (nAb) responses are both thought to be important responses to elicit through vaccination. This thesis characterises neutralizing response in two cohorts in Africa, ... Read more
Viral escape from HIV-1 neutralizing antibodies drives increased plasma neutralization breadth through sequential recognition of multiple epitopes and immunotypes

Author: Wibmer, Constantinos Kurt ; Bhiman, Jinal N ; Gray, Elin S ; Tumba, Nancy ; Karim, Salim S Abdool ; Williamson, Carolyn ; Morris, Lynn ; Moore, Penny L Date: 2013 Identifying the targets of broadly neutralizing antibodies to HIV-1 and understanding how these antibodies develop remain important goals in the quest to rationally develop an HIV-1 vaccine. We previously identified a participant in the CAPRISA ... Read more c b

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