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Browsing by Author "Mlisana, Koleka"

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Anaemia in acute HIV-1 subtype C infection

Author: Mlisana, Koleka ; Auld, Sara C ; Grobler, Anneke ; Loggerenberg, Francois van ; Williamson, Carolyn ; Iriogbe, Itua ; Sobieszczyk, Magdalena E ; Karim, Salim S Abdool ; Team, for the CAPRISA Acute Infection Study Date: 2008 BACKGROUND: The high prevalence of anaemia and the increased morbidity and mortality associated with anaemia during AIDS has been well described yet there has been little information about anaemia and changes in haemoglobin levels during acute ... Read more c b
Challenges of diagnosing acute HIV-1 subtype C infection in African women: performance of a clinical algorithm and the need for point-of-care nucleic-acid based testing

Author: Mlisana, Koleka ; Sobieszczyk, Magdalena ; Werner, Lise ; Feinstein, Addi ; van Loggerenberg, Francois ; Naicker, Nivashnee ; Williamson, Carolyn ; Garrett, Nigel Date: 2013 BACKGROUND: Prompt diagnosis of acute HIV infection (AHI) benefits the individual and provides opportunities for public health intervention. The aim of this study was to describe most common signs and symptoms of AHI, correlate these with ... Read more c b
Conserved positive selection signals in gp41 across multiple subtypes and difference in selection signals detectable in gp41 sequences sampled during acute and chronic HIV-1 subtype C infection

Author: Bandawe, Gama P ; Martin, Darren P ; Treurnicht, Florette ; Mlisana, Koleka ; Karim, Salim S A ; Williamson, Carolyn Date: 24 Nov 2008 Background: The high diversity of HIV variants driving the global AIDS epidemic has caused many to doubt whether an effective vaccine against the virus is possible. However, by identifying the selective forces that are driving the ongoing ... Read more
Conserved positive selection signals in gp41 across multiple subtypes and difference in selection signals detectable in gp41 sequences sampled during acute and chronic HIV-1 subtype C infection

Author: Bandawe, Gama ; Martin, Darren ; Treurnicht, Florette ; Mlisana, Koleka ; Karim, Salim ; Williamson, Carolyn Date: 2008 BACKGROUND:The high diversity of HIV variants driving the global AIDS epidemic has caused many to doubt whether an effective vaccine against the virus is possible. However, by identifying the selective forces that are driving the ongoing ... Read more c b
Continued follow-up of Phambili Phase 2b randomized HIV-1 vaccine trial participants supports increased HIV-1 acquisition among vaccinated men

Author: Moodie, Zoe ; Metch, Barbara ; Bekker, Linda-Gail ; Churchyard, Gavin ; Nchabeleng, Maphoshane ; Mlisana, Koleka ; Laher, Fatima ; Roux, Surita ; Mngadi, Kathryn ; Innes, Craig Date: 2015 BACKGROUND: The Phase 2b double-blinded, randomized Phambili/HVTN 503 trial evaluated safety and efficacy of the MRK Ad5 gag / pol / nef subtype B HIV-1 preventive vaccine vs placebo in sexually active HIV-1 seronegative participants in South ... Read more c b
Establishing a cohort at high risk of HIV infection in South Africa: challenges and experiences of the CAPRISA 002 acute infection study

Author: van Loggerenberg, Francois ; Mlisana, Koleka ; Williamson, Carolyn ; Auld, Sara C ; Morris, Lynn ; Gray, Clive M ; Karim, Quarraisha Abdool ; Grobler, Anneke ; Barnabas, Nomampondo ; Iriogbe, Itua Date: 2008 Objectives To describe the baseline demographic data, clinical characteristics and HIV-incidence rates of a cohort at high risk for HIV infection in South Africa as well as the challenges experienced in establishing and maintaining the cohort. ... Read more c b
Limited neutralizing antibody specificities drive neutralization escape in early HIV-1 subtype C infection

Author: Moore, Penny L ; Ranchobe, Nthabeleng ; Lambson, Bronwen E ; Gray, Elin S ; Cave, Eleanor ; Abrahams, Melissa-Rose ; Bandawe, Gama ; Mlisana, Koleka ; Karim, Salim S Abdool ; Williamson, Carolyn Date: 2009 Author Summary Most HIV-1 infected individuals develop neutralizing antibodies against their own virus, termed an autologous neutralizing response. It is known that this response exerts pressure on the envelope of HIV, the target of such ... Read more c b
Predictors of HVTN 503 MRK-AD5 HIV-1 gag/pol/nef vaccine Induced immune responses

Author: Hopkins, Kathryn L ; Laher, Fatima ; Otwombe, Kennedy ; Churchyard, Gavin ; Bekker, Linda-Gail ; DeRosa, Stephen ; Nchabeleng, Maphoshane ; Mlisana, Koleka ; Kublin, James ; Gray, Glenda Date: 2014 BACKGROUND: Phambili, the Merck (MRK)-Adenovirus Type 5 (Ad5) HIV-1 gag/pol/nef subtype B vaccine study, conducted in South Africa, suspended enrollment and vaccination when companion study, Step, was found non-efficacious. Although the vaccine ... Read more c b
Pregnancy incidence and correlates during the HVTN 503 Phambili HIV vaccine trial conducted among South African women

Author: Latka, Mary H ; Fielding, Katherine ; Gray, Glenda E ; Bekker, Linda-Gail ; Nchabeleng, Maphoshane ; Mlisana, Koleka ; Nielson, Tanya ; Roux, Surita ; Mkhize, Baningi ; Mathebula, Matsontso Date: 2012 BACKGROUND: HIV prevention trials are increasingly being conducted in sub-Saharan Africa. Women at risk for HIV are also at risk of pregnancy. To maximize safety, women agree to avoid pregnancy during trials, yet pregnancies occur. Using data ... Read more c b
Sequential Immunization with gp140 boosts immune responses primed by modified vaccinia Ankara or DNA in HIV-uninfected South African participants

Author: Churchyard, Gavin ; Mlisana, Koleka ; Karuna, Shelly ; Williamson, Anna-Lise ; Williamson, Carolyn ; Morris, Lynn ; Tomaras, Georgia D ; De Rosa, Stephen C ; Gilbert, Peter B ; Gu, Niya ; Yu, Chenchen ; Mkhize, Nonhlanhla N ; Hermanus, Tandile ; Allen, Mary ; Pensiero, Michael ; Barnett, Susan W ; Gray, Glenda ; Bekker, Linda-Gail ; Montefiori, David C ; Kublin, James ; Corey, Lawrence Date: 2016 BACKGROUND: The safety and immunogenicity of SAAVI DNA-C2 (4 mg IM), SAAVI MVA-C (2.9 x 10 9 pfu IM) and Novartis V2-deleted subtype C gp140 (100 mcg) with MF59 adjuvant in various vaccination regimens was evaluated in HIV-uninfected adults ... Read more c b
Testing the regulatory framework in South Africa – a single-blind randomized pilot trial of commercial probiotic supplementation to standard therapy in women with bacterial vaginosis

Author: Happel, Anna-Ursula ; Singh, Ravesh ; Mitchev, Nireshni ; Mlisana, Koleka ; Jaspan, Heather B ; Barnabas, Shaun L ; Passmore, Jo-Ann S Date: 10 Jul 2020 Abstract Background Bacterial vaginosis (BV) increases HIV risk and adverse reproductive outcomes. Standard-of-care (SOC) for BV are antibiotics; however, cure rates are low. Probiotics for vaginal health may be useful in improving cure and ... Read more
Transmission of HIV-1 CTL escape variants provides HLA-mismatched recipients with a survival advantage

Author: Chopera, Denis R ; Woodman, Zenda ; Mlisana, Koleka ; Mlotshwa, Mandla ; Martin, Darren P ; Seoighe, Cathal ; Treurnicht, Florette ; Rosa, Debra Assis de ; Hide, Winston ; Karim, Salim Abdool Date: 2008 Author Summary Following infection with HIV, it is well established that a person's genetic makeup is a major determinant of how quickly they will progress to AIDS. Particularly important is the class I Human leukocyte antigen (HLA) gene that ... Read more c b
Utilizing nucleic acid amplification to identify acute HIV infection

Author: Karim, Salim S Abdool ; Mlisana, Koleka ; Kharsany, Ayesha B M ; Williamson, Carolyn ; Baxter, Cheryl ; Karim, Quarraisha Abdool Date: 2007 Two case reports have recently been published describing possible immune reconstitution inflammatory syndrome (IRIS) to Strongyloides infection [1,2]; however, there is debate as to whether the presentations may alternatively be caused by ... Read more

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Browsing by Author "Mlisana, Koleka"

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