OpenUCT Home
→
Browsing by Author

Browsing by Author "Mizrahi, Valerie"

Now showing items 1-14 of 14

Cleavage of the moaX-encoded fused molybdopterin synthase from Mycobacterium tuberculosis is necessary for activity

Author: Narrandes, Nicole C ; Machowski, Edith E ; Mizrahi, Valerie ; Kana, Bavesh D Date: 06 Feb 2015 Background: Molybdopterin cofactor (MoCo) biosynthesis in Mycobacterium tuberculosis is associated with a multiplicity of genes encoding several enzymes in the pathway, including the molybdopterin (MPT) synthase, a hetero tetramer comprising ... Read more c b
Disabling the intrinsic resistome of Mycobacterium tuberculosis: elucidating hierarchies of DNA repair and mutagenesis that undermine current antibiotic efficacy

Author: Gobe, Irene Date: 2021 DNA damage repair mechanisms are critical to the adaptive evolution of Mycobacterium tuberculosis as obligate human pathogen, including the emergence of drug-resistance during anti-tuberculosis (TB) chemotherapy. In experimental models, ... Read more
Elucidation of mechanisms of antibiotic subversion in mycobacteria

Author: Naran, Krupa Date: 2015 The intrinsic resistance of Mycobacterium tuberculosis ( Mtb ) to antibiotics is generally attributed to multiple factors, most significantly the low permeability of the mycobacterial cell wall, the operation of various drug inactivating ... Read more
A high-throughput screen against pantothenate synthetase (PanC) identifies 3-biphenyl-4-cyanopyrrole-2-carboxylic acids as a new class of inhibitor with activity against Mycobacterium tuberculosis

Author: Kumar, Anuradha ; Casey, Allen ; Odingo, Joshua ; Kesicki, Edward A ; Abrahams, Garth ; Vieth, Michal ; Masquelin, Thierry ; Mizrahi, Valerie ; Hipskind, Philip A ; Sherman, David R Date: 2013 The enzyme pantothenate synthetase, PanC, is an attractive drug target in Mycobacterium tuberculosis . It is essential for the in vitro growth of M. tuberculosis and for survival of the bacteria in the mouse model of infection. PanC is absent ... Read more c b
Identification of new drug targets and resistance mechanisms in Mycobacterium tuberculosis

Author: Ioerger, Thomas R ; O'Malley, Theresa ; Liao, Reiling ; Guinn, Kristine M ; Hickey, Mark J ; Mohaideen, Nilofar ; Murphy, Kenan C ; Boshoff, Helena I M ; Mizrahi, Valerie ; Rubin, Eric J Date: 2013 Identification of new drug targets is vital for the advancement of drug discovery against Mycobacterium tuberculosis , especially given the increase of resistance worldwide to first- and second-line drugs. Because traditional target-based ... Read more c b
Molecular mechanisms of DNA repair in Mycobacterium tuberculosis

Author: Gessner, Sophia Johanna Date: 2017 The mycobacterial DNA damage and repair pathways involved in the emergence of drug-resistance during host infection remain poorly understood, yet are critical to any efforts to develop novel "anti-evolution" drugs aimed at reducing the capacity ... Read more
Real-time investigation of tuberculosis transmission: developing the Respiratory Aerosol Sampling Chamber (RASC)

Author: Wood, Robin ; Morrow, Carl ; III, Clifton E Barry ; Bryden, Wayne A ; Call, Charles J ; Hickey, Anthony J ; Rodes, Charles E ; Scriba, Thomas J ; Blackburn, Jonathan ; Issarow, Chacha ; Mulder, Nicola ; Woodward, Jeremy ; Moosa, Atica ; Singh, Vinayak ; Mizrahi, Valerie ; Warner, Digby F Date: 2016 Knowledge of the airborne nature of respiratory disease transmission owes much to the pioneering experiments of Wells and Riley over half a century ago. However, the mechanical, physiological, and immunopathological processes which drive the ... Read more c b
Replication fidelity in the mircroevolution of mycobacteria

Author: Ditse, Zanele Date: 2015 This thesis aimed to elucidate the structure-function relationships determining the differential fidelities of the dnaE1- and dnaE2-encoded mycobacterial PolIIIÎ± subunits under conditions of genotoxic stress. To this end, the role in DnaE1 ... Read more
Riboswitch regulation of methionine metabolism and vitamin B12 uptake in mycobacteria – implications for drug susceptibility and pathogenesis

Author: Kipkorir, Terry Date: 2019 Alterations in the genetic capacity for cobamide biosynthesis have been identified as potentially critical in the evolution of Mycobacterium tuberculosis from a putative environmental ancestor. Moreover, recent studies have implicated cobamide ... Read more
The structure and reactivity of N-Acyl phosphoric amides and related systems

Author: Mizrahi, Valerie Date: 1983 Two synthetic approaches towards the N-acyl phosphylamide system Z₂P(O)-NR-C(O)R' (1; Z =alkyl, O-alkyl; R = H, Me; R' =M e, Ph), from phosphylamide and carboxamide precursors are discussed. The infrared, ¹H and ¹³C NMR spectral features of ... Read more
Subcellular localization and visualization of RecA and ImuAʹ in mycobacteria

Author: Ramudzuli, Atondaho Angelah Date: 2021 Antibiotic-resistant strains of Mycobacterium tuberculosis (Mtb) are threatening global efforts to eradicate tuberculosis (TB). One attractive approach for target-based drug design proposes to curb the evolution of Mtb during both immune and ... Read more
Translating genomics research into control of tuberculosis: lessons learned and future prospects

Author: Warner, Digby F ; Mizrahi, Valerie Date: 07 Nov 2014 Genomics research has enabled crucial insights into the adaptive evolution of Mycobacterium tuberculosis as an obligate human pathogen. Here, we highlight major recent advances and evaluate the potential for genomics approaches to inform ... Read more c b
Translational research for tuberculosis elimination: priorities, challenges, and actions

Author: Lienhardt, Christian ; Lönnroth, Knut ; Menzies, Dick ; Balasegaram, Manica ; Chakaya, Jeremiah ; Cobelens, Frank ; Cohn, Jennifer ; Denkinger, Claudia M ; Evans, Thomas G ; Källenius, Gunilla ; Kaplan, Gilla ; Kumar, Ajay M V ; Matthiessen, Line ; Mgone, Charles S ; Mizrahi, Valerie ; Mukadi, Ya-diul ; Nguyen, Viet Nhung ; Nordström, Anders ; Sizemore, Christine F ; Spigelman, Melvin ; Squire, S Bertel ; Swaminathan, Soumya ; Helden, Paul D Van ; Zumla, Alimuddin ; Weyer, Karin ; Weil, Diana ; Raviglione, Mario Date: 2016 Christian Lienhardt and colleagues describe the research efforts needed to end the global tuberculosis epidemic by 2035. Read more c b
Whole-genome transposon mutagenesis to elucidate the genetic requirements for vitamin B12 biosynthesis and assimilation in mycobacteria

Author: Mbau, Rendani Donald Date: 2022 Comparative genomic analyses have identified an altered capacity for cobalamin biosynthesis as a critical step in the evolution of the pathogenic Mycobacterium tuberculosis Complex strains from a common environmental ancestor. However, resolving ... Read more

Now showing items 1-14 of 14

Browse

All of OpenUCT

Browsing by Author "Mizrahi, Valerie"

Browsing by Author "Mizrahi, Valerie"

Browse

All of OpenUCT