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Browsing by Author "Meyers, Ann"

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Abrogation of contaminating RNA activity in HIV-1 Gag VLPs

Author: Valley-Omar, Ziyaad ; Meyers, Ann ; Shephard, Enid ; Williamson, Anna-Lise ; Rybicki, Edward Date: 2011 BACKGROUND: HIV-1 Gag virus like particles (VLPs) used as candidate vaccines are regarded as inert particles as they contain no replicative nucleic acid, although they do encapsidate cellular RNAs. During HIV-1 Gag VLP production in ... Read more c b
Beak and feather disease virus candidate vaccine development

Author: Duvenage, Lucian Date: 2012 [Fix supervisors field.] Psittacine beak and feather disease, caused by a circovirus known as beak and feather disease virus (BFDV), is a threat to both wild and captive psittacine species. There is currently no vaccine against BFDV and safe ... Read more
Chimaeric HIV-1 subtype C Gag molecules with large in-frame C-terminal polypeptide fusions form virus-like particles.

Author: Halsey, Richard J ; Tanzer, Fiona L ; Meyers, Ann ; Pillay, Sirika ; Lynch, Alisson ; Shephard, Enid ; Williamson, Anna-Lise ; Rybicki, Edward P Date: 2008 HIV-1 Pr55 Gag virus-like particles (VLPs) are strong immunogens with potential as candidate HIV vaccines. VLP immunogenicity can be broadened by making chimaeric Gag molecules: however, VLPs incorporating polypeptides longer than 200 aa fused ... Read more
Development of a transformation protocol and cell culture system for the commercially important species of red macroalga, Gracilaria gracilis

Author: Huddy, Suzanne Margaret Date: 2011 A better understanding of how this commercially important seaweed responds at a genetic level to stresses faced in the aquaculture environment would not only be advantageous to the South African industry, but this knowledge is essential for ... Read more
Development of plant-produced African horse sickness vaccines

Author: Dennis, Susan Jennifer Date: 2019 African horse sickness is a devastating disease that causes great suffering and many fatalities amongst horses in sub-Saharan Africa. It is caused by nine different serotypes of the orbivirus African horse sickness virus (AHSV) and it is ... Read more
Development of plant-produced Bluetongue virus vaccines

Author: van Zyl, Albertha R Date: 2014 Bluetongue is a disease of domestic and wild ruminants caused by Bluetongue virus (BTV). It has caused several serious outbreaks, the most recent occurring in Northern Europe in 2006 during which high mortality rates of livestock were reported. ... Read more
Development of Rift Valley fever virus candidate vaccines and reagents produced in Nicotiana benthamiana

Author: Mbewana, Sandiswa Date: 2017 Rift Valley fever (RVF) is a haemorrhagic fever agent caused by an infection with an enveloped negative-stranded RNA Rift Valley fever virus (RVFV). It belongs to the genus Phlebovirus in the family Bunyaviridae. The virus is spread by infected ... Read more
Development of West Nile virus candidate vaccines in Nicotiana benthamiana

Author: Wayland, Jennifer Date: 2021 West Nile virus (WNV) is a widely disseminated flavivirus, with a geographical range that now includes Africa, America, Europe, the Middle East, West Asia and Australia. The virus is vectored by Culex mosquitoes and is maintained in a ... Read more
Expression of HIV-1 antigens in plants as potential subunit vaccines

Author: Meyers, Ann ; Chakauya, Ereck ; Shephard, Enid ; Tanzer, Fiona ; Maclean, James ; Lynch, Alisson ; Williamson, Anna-Lise ; Rybicki, Edward Date: 2008 BACKGROUND: Human immunodeficiency virus type 1 (HIV-1) has infected more than 40 million people worldwide, mainly in sub-Saharan Africa. The high prevalence of HIV-1 subtype C in southern Africa necessitates the development of cheap, effective ... Read more c b
HIV-1 sub-type C chimaeric VLPs boost cellular immune responses in mice

Author: Pillay, Sirika ; Shephard, Enid ; Meyers, Ann ; Williamson, Anna-Lise ; Rybicki, Edward P Date: 2010 Several approaches have been explored to eradicate HIV; however, a multigene vaccine appears to be the best option, given their proven potential to elicit broad, effective responses in animal models. The Pr55Gag protein is an excellent vaccine ... Read more c b
HPV pseudovirion production in plants

Author: Kennedy, Paul Date: 2013 Human papilloma virus (HPV) infection is the most common etiological agent of cervical cancer, the most common cancer in women in Africa. The lifecycle of HPV has historically made the virus difficult to culture in vitro, and this has hindered ... Read more
Investigating the production of a particulate plant-produced vaccine candidate against African horse sickness

Author: Luhanga, Gloria Date: 2021 African horse sickness (AHS) is a non-communicable, infectious disease that affects equids and is mainly prevalent in sub-Saharan Africa. The disease has a major impact on the economy of the equine industry as well as an emotional impact on ... Read more
An investigation into improved HIV-1 subtype C envelope based vaccine design

Author: Margolin, Emmanuel Aubrey Date: 2014 Includes abstract. Includes bibliographical references. Read more
Investigation of particulate HIV-1 Env vaccine candidates using Zera® and SpyTag/SpyCatcher technologies

Author: Ximba, Phindile Thobeka Date: 2022 The HIV-1 envelope glycoprotein (Env) is the primary focus of prophylactic HIV vaccine development. However, the unusually low density of Env spikes on the virion (≈14 spikes/virion) is unfavourable for eliciting high titre, long-lasting ... Read more
Novel expression and production of Foot-and-mouth disease virus vaccine candidates in Nicotiana benthamiana

Author: Veerapen, Varusha Pillay Date: 2017 Foot-and-mouth disease, also known as FMD, is caused by the aphthovirus Foot-and-mouth disease virus (FMDV), which is a highly contagious disease of cloven-hoofed animals. It is endemic in Africa, parts of South America and southern Asia. In ... Read more
Optimization of chimaeric HIV-1 virus-like particle (VLP) production and immunogenicity testing of VLPs in mice

Author: Pillay, Sirika Date: 2008 The devastating effect the HIV pandemic has had on the human population in the last twenty five years has highlighted the great need to develop a prophylactic HIV vaccine. The manufacture of a vaccine has proven difficult though, with a number ... Read more
Plant-expressed diagnostic proteins and their use for the identification and differentiation of infected and vaccinated animals with foot-and-mouth disease virus

Author: De Beer, Scott Date: 2017 The Foot-and-mouth disease virus (FMDV) affects cloven-hoofed animals and is endemic in most parts of Africa, South America and southern Asia. South Africa is considered a FMDV-free zone but the virus is maintained within the wildlife in the ... Read more
The production of a Crimean-Congo haemorrhagic fever virus diagnostic antigen in plants

Author: Atkinson, Richard Date: 2016 Crimean-Congo Hemorrhagic Fever (CCHF) is a highly infectious, life threatening disease, caused by the Crimean-Congo Hemorrhagic Fever Virus (CCHFV), a nairovirus that forms part of the Bunyaviridae family. CCHFV has a case fatality rate ... Read more
RNA transmission and expression from inert HIV candidate vaccine virus-like-particles

Author: Valley-Omar, Ziyaad Date: 2008 HIV-1 Gag virus-like-particles (VLPs) produced in various expression systems are potent stimulators of both cellular and humoral immune responses in animal models. The encapsidation of large concentrations of random cellular RNA species is ... Read more
Stability studies of HIV-1 Pr55gag virus-like particles made in insect cells after storage in various formulation media

Author: Lynch, Alisson ; Meyers, Ann ; Williamson, Anna-Lise ; Rybicki, Edward Date: 2012 BACKGROUND:HIV-1 Pr55gag virus-like particles (VLPs) expressed by baculovirus in insect cells are considered to be a very promising HIV-1 vaccine candidate, as they have been shown to elicit broad cellular immune responses when tested in ... Read more c b

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