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Browsing by Author "Mearns, Helen"

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Delayed goblet cell hyperplasia, acetylcholine receptor expression, and worm expulsion in SMC-specific IL-4Ralpha-deficient mice

Author: Horsnell, William G C ; Cutler, Antony J ; Hoving, J Claire ; Mearns, Helen ; Myburgh, Elmarie ; Arendse, Berenice ; Finkelman, Fred D ; Owens, Gary K ; Erle, Dave ; Brombacher, Frank Date: 2007 Interleukin 4 receptor α (IL-4Rα) is essential for effective clearance of gastrointestinal nematode infections. Smooth muscle cells are considered to play a role in the type 2 immune response-driven expulsion of gastrointestinal nematodes. ... Read more c b
The function of IL-4Rα expression on key immune cells during experimental Nippostrongylus brasiliensis infections

Author: Mearns, Helen Date: 2006 The lifecycle of the parasitic nematode Nippostrogylus brasiliensis resembles that of the human hookworms Necator americanus and Ancylostoma duodenale and as such is a useful murine model for studying hookworm disease. Read more
Nippostrongylus-induced intestinal hypercontractility requires IL-4 receptor alpha-responsiveness by T cells in mice

Author: Schmidt, Saskia ; Hoving, J Claire ; Horsnell, William G C ; Mearns, Helen ; Cutler, Antony J ; Brombacher, Tiroyaone M ; Brombacher, Frank Date: 2012 Gut-dwelling helminthes induce potent IL-4 and IL-13 dominated type 2 T helper cell (T H 2) immune responses, with IL-13 production being essential for Nippostrongylus brasiliensis expulsion. This T H 2 response results in intestinal inflammation ... Read more c b

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Browsing by Author "Mearns, Helen"

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