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Browsing by Author "Mayosi, Bongani"

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Analysis of desmoplakin in arrythmogenic right ventricular cardiomyopathy

Author: Fish, Maryam Date: 2010 It has been shown that all forms of cardiomyopathy, including the dilated, hypertrophic, restrictive, and right ventricular arrhythmogenic forms, are found in African populations. Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a ... Read more
Antibiotics for the primary prevention of acute rheumatic fever: a meta-analysis

Author: Robertson, Katharine ; Volmink, Jimmy ; Mayosi, Bongani Date: 2005 BACKGROUND:Rheumatic fever continues to put a significant burden on the health of low socio-economic populations in low and middle-income countries despite the near disappearance of the disease in the developed world over the past century. ... Read more c b
Arrhythmogenic right ventricular cardiomyopathy type 6 (ARVC6): support for the locus assignment, narrowing of the critical region and mutation screening of three candidate genes

Author: Matolweni, Luzuko ; Bardien, Soraya ; Rebello, George ; Oppon, Ekow ; Munclinger, Miroslav ; Ramesar, Rajkumar ; Watkins, Hugh ; Mayosi, Bongani Date: 2006 BACKGROUND:Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a heritable disorder characterized by progressive degeneration of right ventricular myocardium, arrhythmias and an increased risk of sudden death at a young age. By linkage ... Read more c b
Assessing strain in arrhythmogenic right ventricular cardiomyopathy using cine DENSE MRI

Author: Ongori, Joash ; Hendricks, Neil ; Spottiswoode, Bruce ; Meintjes, Ernesta ; Epstein, Frederick ; Mayosi, Bongani Date: 2009 The kinematics of the right ventricle (RV) are not well understood due to its thin wall and asymmetric geometry. Cine displacement encoding with stimulated echoes (cine DENSE), which measures intramyocardial displacement and strain, has been ... Read more c b
The burden of antenatal heart disease in South Africa: a systematic review

Author: Watkins, David ; Sebitloane, Motshedisi ; Engel, Mark E ; Mayosi, Bongani Date: 2012 BACKGROUND: Maternal mortality in South Africa is rising, and heart conditions currently account for 41 per cent of indirect causes of deaths. Little is known about the burden of heart disease in pregnant South Africans. METHODS: We systematically ... Read more c b
Clinical characteristics and initial management of patients with tuberculous pericarditis in the HIV era: the Investigation of the Management of Pericarditis in Africa (IMPI Africa) registry

Author: Mayosi, Bongani ; Wiysonge, Charles ; Ntsekhe, Mpiko ; Volmink, Jimmy ; Gumedze, Freedom ; Maartens, Gary ; Aje, Akinyemi ; Thomas, Baby ; Thomas, Kandathil ; Awotedu, Abolade ; Thembela, Bongani ; Mntla, Phindile ; Maritz, Frans ; Blackett, Kathleen ; Nkouonlack, Date: 2006 BACKGROUND:The incidence of tuberculous pericarditis has increased in Africa as a result of the human immunodeficiency virus (HIV) epidemic. However, the effect of HIV co-infection on clinical features and prognosis in tuberculous pericarditis ... Read more c b
A cost-effectiveness tool to guide the prioritization of interventions for rheumatic fever and rheumatic heart disease control in African nations

Author: Watkins, David ; Lubinga, Solomon J ; Mayosi, Bongani ; Babigumira, Joseph B Date: 2016 Author Summary: Rheumatic heart disease is a major cause of cardiovascular morbidity and mortality in Africa. Although there are effective medications and surgical procedures for rheumatic heart disease, they are under-used. What is more, ... Read more c b
The effect of distance to health facility on the maintenance of INR therapeutic ranges in rheumatic heart disease patients from Cape Town

Author: Barth, Dylan Dominic Date: 2013 Part A: is the research protocol which outlines the background and the process of this research. This study is a population-based observational study nested within the Groote Schuur Hospital (GSH) cohort of a global study, REMEDY which is a ... Read more
Ethical challenges in obtaining informed consent for the genomic study of rheumatic heart disease: a qualitative study

Author: Masiye, Francis Date: 2016 INTRODUCTION: Advances in genetic and genomic research have introduced new challenges in obtaining informed consent for research in low and middle-income settings. However, there are only few studies that have explored challenges in obtaining ... Read more
Genomic medicine in Africa: promise, problems and prospects

Author: Wonkam, Ambroise ; Mayosi, Bongani Date: 2014 Remarkable progress has been made in using genomic information to determine how genes are regulated, and how they interact with each other and with the environment to control complex biochemical functions of living organisms in health and ... Read more c b
“I passed the test!” Evidence of diagnostic misconception in the recruitment of population controls for an H3Africa genomic study in Cape Town, South Africa

Author: Masiye, Francis ; Mayosi, Bongani ; de Vries, Jantina Date: 15 Feb 2017 Background: Advances in genetic and genomic research have introduced challenges in obtaining informed consent for research in low and middle-income settings. However, there are only few studies that have explored challenges in obtaining ... Read more
An immunohistochemical assessment of endomyocardial biopsy specimens from the South African arrhythmogenic right ventricular cardiomyopathy registry

Author: Morse, Nicole Date: 2014 Arrhythmogenic right ventricular cardiomyopathy / dysplasia (ARVC/D) is a genetic disease causing fibro-fatty replacement of the right ventricular myocardium, resulting in cardiac arrhythmias and sudden death. Part of the diagnostic work up ... Read more
Immunological analysis of pericardial tuberculosis

Author: Matthews, Kerryn Date: 2011 Pericardial tuberculosis (TB) offers a relevant human model to study TB at the site of disease and to determine the effect of HIV-1 infection. 96 Patients with pericardial TB were recruited into this study, 68 of whom were HIV-1 infected. ... Read more
Investigation of the management of tuberculous pericarditis (IMPI) registry : survival and outcomes sub-study

Author: Mubanga, Mwenya Date: 2012 Includes abstract. Includes bibliographical references. Read more
The mitochondrial DNA T16189C polymorphism and HIV-associated cardiomyopathy: a genotype-phenotype association study

Author: Shaboodien, Gasnat ; Engel, Mark E ; Syed, Faisal ; Poulton, Joanna ; Badri, Motasim ; Mayosi, Bongani Date: 2009 BACKGROUND: The mitochondrial DNA (mtDNA) T16189C polymorphism, with a homopolymeric C-tract of 10-12 cytosines, is a putative genetic risk factor for idiopathic dilated cardiomyopathy in the African and British populations. We hypothesized ... Read more c b
Molecular genetics of arrhythmogenic right ventricular cardiomyopathy in South Africa

Author: Blanckenberg, Janine Date: 2011 Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a heritable disorder characterised by progressive degeneration of the right ventricular myocardium, arrhythmias and an increased risk of sudden death at a young age. Fourteen chromosomal ... Read more
The prevalence of plakophilin-2 gene (PKP-2) mutations in South African patient with cardiomyopathy

Author: Mbele, Mzwandile Date: 2008 Includes abstract. Includes bibliographical references (leaves 53-58). Read more
Quantification of echodensities in tuberculous pericardial effusion using fractal geometry: a proof of concept study

Author: Ntsekhe, Mpiko ; Mayosi, Bongani ; Gumbo, Tawanda Date: 2012 BACKGROUND:The purpose of this study was to quantify the heterogeneous distribution of echodensities in the pericardial fluid of patients with tuberculous pericarditis using echocardiography and fractal analysis, and to determine whether there ... Read more c b
Reference intervals for the echocardiographic measurements of the right heart in children and adolescents: a systematic review

Author: Lemmer (Hunsinger), Carolina ; Engel, Mark E ; Stanfliet, John ; Mayosi, Bongani Date: 2014 BACKGROUND: Transthoracic echocardiography is the primary imaging modality for the diagnosis of right ventricular (RV) involvement in congenital and acquired heart diseases. There is increasing recognition of the contribution of RV dysfunction ... Read more c b
STK39 polymorphisms and blood pressure: an association study in British Caucasians and assessment of cis-acting influences on gene expression

Author: Cunnington, Michael S ; Kay, Chris ; Avery, Peter ; Mayosi, Bongani ; Koref, Mauro ; Keavney, Bernard Date: 2009 BACKGROUND:Blood pressure (BP) has significant heritability, but the genes responsible remain largely unknown. Single nucleotide polymorphisms (SNPs) at the STK39 locus were recently associated with hypertension by genome-wide association in ... Read more c b

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