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Browsing by Author "Masimirembwa, Collen"

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A cost effective RFLP method to genotype Solute carrier organic anion 1B1 (SLCO1B1) c.1929A>C (p.Leu643Phe, rs34671512); a variant with potential effect on rosuvastatin pharmacokinetics

Author: Soko, Nyarai D ; Masimirembwa, Collen ; Dandara, Collet Date: 14 Jun 2018 Objective: This study describes a restriction fragment polymorphism protocol for rapidly screening the polymorphism SLCO1B1 c.1929A>C in genomic DNA samples. The polymorphism SLCO1B1 c.1929A>C has been associated with increased activity ... Read more
Antimalarial drug rescue through safety improvement: design, synthesis and evaluation of amaodiaquine analogues

Author: Ongarora, Dennis Sure Bagwasi Date: 2014 Malaria is a major cause of morbidity and mortality globally, resulting in over 200 million cases and 650, 000 deaths in 2010 according to the 2012 WHO Malaria Report. Furthermore, malaria endemicity is associated with poor economic growth. ... Read more
Integration of In Silico and In Vitro ADMET properties in lead identification and optimization of compounds for the treatment of parasitic diseases

Author: Thelingwani, Roslyn Date: 2012 Parasitic infections are the major causes of illness and death in tropical regions especially in Africa. The main parasitic diseases include leishmaniasis, filariasis, malaria, river blindness, Chagas disease and schistosomiasis. With the ... Read more
Novel variants of major drug-metabolising enzyme genes in diverse African populations and their predicted functional effects

Author: Matimba, Alice ; Del-Favero, Jurgen ; Van Broeckhoven, Christine ; Masimirembwa, Collen Date: 2009 Pharmacogenetics enables personalised therapy based on genetic profiling and is increasingly applied in drug discovery. Medicines are developed and used together with pharmacodiagnostic tools to achieve desired drug efficacy and safety margins. ... Read more c b
Pharmacogenetics of African populations : variation in major drug metabolising enzyme genes and potential impact on personalised medicine.

Author: Matimba, Alice Date: 2009 Includes bibliographical references (leaves 167-200) Read more
The Next Generation Scientist program: capacity-building for future scientific leaders in low- and middle-income countries

Author: Pillai, Goonaseelan ; Chibale, Kelly ; Constable, Edwin C ; Keller, Akiko N ; Gutierrez, Marcelo M ; Mirza, Fareed ; Sengstag, Christian ; Masimirembwa, Collen ; Denti, Paolo ; Maartens, Gary ; Ramsay, Michèle ; Ogutu, Bernhards ; Makonnen, Eyasu ; Gordon, Richard ; Ferreira, Carlos G ; Goldbaum, Fernando A ; Degrave, Wim M S ; Spector, Jonathan ; Tadmor, Brigitta ; Kaiser, Hedwig J Date: 10 Oct 2018 Background Scientific and professional development opportunities for early career scientists in low- and middle- income countries (LMICs) are limited and not consistent. There is a disproportionately low number of biomedical ... Read more

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Browsing by Author "Masimirembwa, Collen"

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