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Browsing by Author "Lynch, Alisson"

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Chimaeric HIV-1 subtype C Gag molecules with large in-frame C-terminal polypeptide fusions form virus-like particles.

Author: Halsey, Richard J ; Tanzer, Fiona L ; Meyers, Ann ; Pillay, Sirika ; Lynch, Alisson ; Shephard, Enid ; Williamson, Anna-Lise ; Rybicki, Edward P Date: 2008 HIV-1 Pr55 Gag virus-like particles (VLPs) are strong immunogens with potential as candidate HIV vaccines. VLP immunogenicity can be broadened by making chimaeric Gag molecules: however, VLPs incorporating polypeptides longer than 200 aa fused ... Read more
Expression of HIV-1 antigens in plants as potential subunit vaccines

Author: Meyers, Ann ; Chakauya, Ereck ; Shephard, Enid ; Tanzer, Fiona ; Maclean, James ; Lynch, Alisson ; Williamson, Anna-Lise ; Rybicki, Edward Date: 2008 BACKGROUND: Human immunodeficiency virus type 1 (HIV-1) has infected more than 40 million people worldwide, mainly in sub-Saharan Africa. The high prevalence of HIV-1 subtype C in southern Africa necessitates the development of cheap, effective ... Read more c b
Stability studies of HIV-1 Pr55gag virus-like particles made in insect cells after storage in various formulation media

Author: Lynch, Alisson ; Meyers, Ann ; Williamson, Anna-Lise ; Rybicki, Edward Date: 2012 BACKGROUND:HIV-1 Pr55gag virus-like particles (VLPs) expressed by baculovirus in insect cells are considered to be a very promising HIV-1 vaccine candidate, as they have been shown to elicit broad cellular immune responses when tested in ... Read more c b
Use of the piggyBac transposon to create HIV-1 gag transgenic insect cell lines for continuous VLP production

Author: Lynch, Alisson ; Tanzer, Fiona ; Fraser, Malcolm ; Shephard, Enid ; Williamson, Anna-Lise ; Rybicki, Edward Date: 2010 BACKGROUND: Insect baculovirus-produced Human immunodeficiency virus type 1 (HIV-1) Gag virus-like-particles (VLPs) stimulate good humoral and cell-mediated immune responses in animals and are thought to be suitable as a vaccine candidate. ... Read more c b

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