Author:Oosthuizen, JennaDate:2018There has been growing research on the impact of HIV on family planning and fertility behaviours with studies showing conflicting results. However, these relationships have been understudied in sub-Saharan Africa, especially during the ...Read more
Author:Brown, KarrynDate:2018The characteristics of South Africa’s HIV epidemic mean that approximately 28% of women presenting for antenatal care, are HIV-infected. Maternal HIV-infection can lead to mother-to-child transmission (MTCT) of HIV during pregnancy, labour, ...Read more
Author:Macginty, RaeDate:2017Background: Wheezing is one of the most common respiratory illnesses in children worldwide. Severe wheeze can result in significant morbidity, caregiver burden and increased health care costs. In addition, early childhood wheeze may be ...Read more
Author:Hannan, Patrick LukeDate:2019Introduction
Wheezing is common in young children. By the age of six, approximately 50% of children in high-income countries will have experienced at least one episode of wheezing in their life. Furthermore, childhood wheezing may be ...Read more
Author:Gunsaru, Vester PoyambaDate: 2018The burden of tuberculosis (TB) is high globally and in sub-Saharan Africa (SSA). Although TB treatment regimens are now widely available, and with high success rates in most parts of the world, TB can lead to long-term health consequences. ...Read more
Author:Decloedt, Eric H; Lesosky, Maia; Maartens, Gary; Joska, John ADate:04 Feb 2017Background: The prevalence of bipolar disorder in HIV-infected patients is higher than the general population. Lithium is the most effective mood stabiliser, while tenofovir disoproxil fumarate (TDF) is frequently used as part of combination ...Read morecb
Author:Lesosky, Maia; Joska, John; Decloedt, EricDate:07 Jun 2017Background: Therapeutic drug monitoring (TDM) is essential practice when dosing drugs with a narrow therapeutic index in order to achieve a plasma drug concentration within a narrow target range above the efficacy concentration but below the ...Read more
Author:O'Donnell, WarwickDate:2013This work details the method of Simultaneous Model-based Clustering. It also presents an extension to this method by reformulating it as a model with a mixture of factor analysers. This allows for the technique, known as Simultaneous Model-Based ...Read more
Author:Sarkin, LeeDate:2019Background: The scale-up of combination antiretroviral therapy (ART), one of the greatest pharmacological interventions in human history, has reduced adult HIV-related deaths in South Africa by around 70% between the peak in 2005 and 2019, ...Read more
Author:Rambau, Brian ThabaneDate:2019During aetiology of respiratory illnesses, it is widely accepted that infection is preceded by nasopharyngeal (NP) colonisation with bacteria and that NP flora develop early in childhood (during the first year of life). The presence of multiple ...Read more