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Browsing by Author "Lenders, Laura"

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Clinical utility of a commercial LAM-ELISA assay for TB diagnosis in HIV-infected patients using urine and sputum samples

Author: Dheda, Keertan ; Davids, Virginia ; Lenders, Laura ; Roberts, Teri ; Meldau, Richard ; Ling, Daphne ; Brunet, Laurence ; Smit, Richard van Zyl ; Peter, Jonathan ; Green, Clare ; Badri, Motasim ; Sechi, Leonardo ; Sharma, Surendra ; Hoelscher, Michael ; Dawson, Rodney Date: 2010 BACKGROUND: The accurate diagnosis of TB in HIV-infected patients, particularly with advanced immunosuppression, is difficult. Recent studies indicate that a lipoarabinomannan (LAM) assay (Clearview-TB®-ELISA) may have some utility for the ... Read more c b
Correlation of mycobacterium tuberculosis specific and non-specific quantitative Th1 T-cell responses with bacillary load in a high burden setting

Author: Theron, Grant ; Peter, Jonny ; Lenders, Laura ; van Zyl-Smit, Richard ; Meldau, Richard ; Govender, Ureshnie ; Dheda, Keertan Date: 2012 BACKGROUND: Measures of bacillary load in patients with tuberculosis (TB) may be useful for predicting and monitoring response to treatment. The relationship between quantitative T-cell responses and mycobacterial load remains unclear. We ... Read more c b
Diagnostic accuracy of quantitative PCR (Xpert MTB/RIF) for tuberculous meningitis in a high burden setting: a prospective study

Author: Patel, Vinod B ; Theron, Grant ; Lenders, Laura ; Matinyena, Brian ; Connolly, Cathy ; Singh, Ravesh ; Coovadia, Yacoob ; Ndung'u, Thumbi ; Dheda, Keertan Date: 2013 Background: Tuberculous meningitis (TBM) is difficult to diagnose promptly. The utility of the Xpert MTB/RIF test for the diagnosis of TBM remains unclear, and the effect of host- and sample-related factors on test performance is unknown. ... Read more c b
Modern lineages of Mycobacterium tuberculosis exhibit lineage-specific patterns of growth and cytokine induction in human monocyte-derived macrophages

Author: Sarkar, Rajesh ; Lenders, Laura ; Wilkinson, Katalin A ; Wilkinson, Robert J ; Nicol, Mark P Date: 2012 BACKGROUND: Strains of Mycobacterium tuberculosis vary in virulence. Strains that have caused outbreaks in the United States and United Kingdom have been shown to subvert the innate immune response as a potential immune evasion mechanism. ... Read more c b

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Browsing by Author "Lenders, Laura"

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