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Browsing by Author "Leaner, Virna D"

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A tight balance of Karyopherin β1 expression is required in cervical cancer cells

Author: Carden, Sarah ; van der Watt, Pauline ; Chi, Alicia ; Ajayi-Smith, Aderonke ; Hadley, Katie ; Leaner, Virna D Date: 16 Nov 2018 Background Karyopherin β1 (Kpnβ1) is the main nuclear import protein involved in the transport of cargoes from the cytoplasm into the cell nucleus. Previous research has found Kpnβ1 to be significantly overexpressed in cervical ... Read more
Characterising the anticancer effects of a small molecule with potential to inhibit nuclear import via karyopherin beta1

Author: Mkwanazi, Nonkululeko Date: 2018 The Karyopherin superfamily is a group of soluble transport proteins which are involved in nuclear-cytoplasmic trafficking. Studies have shown the involvement of Karyopherin proteins in nuclear pore assembly, nuclear membrane assembly and DNA ... Read more
The effect of inhibiting KPNB1-mediated nuclear import on cancer cell biology and inflammatory transcription factor signalling

Author: Stelma, Tamara Date: 2018 Cancer remains one of the major causes of morbidity and mortality globally. Many novel and innovative approaches have been employed to develop new chemotherapeutic strategies, of which targeted therapies aim to identify a molecular lesion or ... Read more
Inhibition of Kpnβ1 mediated nuclear import enhances cisplatin chemosensitivity in cervical cancer

Author: Chi, Ru-pin A ; van der Watt, Pauline ; Wei, Wei ; Birrer, Michael J ; Leaner, Virna D Date: 02 Feb 2021 Background Inhibition of nuclear import via Karyopherin beta 1 (Kpnβ1) shows potential as an anti-cancer approach. This study investigated the use of nuclear import inhibitor, INI-43, in combination with cisplatin. ... Read more c b
Inhibition of the transcription factor AP-1 in cervical cancer

Author: Maritz, Michelle Frances Date: 2007 AP-I is a dimeric transcription factor comprised primarily of Jun and Fos family proteins, that regulates numerous genes involved in cell proliferation, differentiation and oncogenesis. The expression of AP-I is shown to play an important ... Read more
Investigating a novel small molecule inhibitor of nuclear import as an anti-cancer approach

Author: Chi, Ru-pin Alicia Date: 2016 The identification of novel cancer-associated biomarkers against which drugs can be developed is anticipated to be beneficial in multiple ways; including their use as monotherapies and in combination with current chemotherapeutic agents for ... Read more
Investigating Karyopherin B1: small molecule interactions for cancer therapy

Author: Strydom, Erin Date: 2016 The advent of gene expression profiling studies has allowed for the identification of genes with potential as disease markers and therapeutic targets. Our laboratory identified the eukaryotic nuclear importer protein Karyopherin B1 (KpnB1), ... Read more
Investigating the role of the Renin Angiotensin System in cancer

Author: Dunn, Cherise Date: 2017 It has recently been discovered that cancer shares a link with metabolic diseases, including that of cardiovascular disease, diabetes, amongst others, where common sets of genes show similar gene expression. There is thus interest to investigate ... Read more
Lamina-associated polypeptide 2 (LAP2) expression patterns in transformed and cancer cells

Author: Ward, Michelle Claire Date: 2009 The Lamina-associated polypeptide two (LAP2) proteins comprising three human isoforms, LAP2 +- LAP2Î² and LAP2 have been shown to provide a structural framework in the nucleus and to facilitate nuclear assembly and disassembly ... Read more
Modulating ADAM-10 activity and expression in cervical and oesophageal cancer cells

Author: Wagiet, Mateen Date: 2016 The ADAMs (A Disintegrin And Metalloproteinase) is a family of transmembrane and secreted proteins essential in cellular fate determination, wound healing, cell migration, proliferation and angiogenesis. Previous studies have linked a range ... Read more
Modulating the expression and activity of the nuclear import protein, Karyopherin β1, in cancer cells

Author: Carden, Sarah Date: 2017 Cancer is primarily a disease of disordered gene expression; the dysregulation of thousands of different genes has been associated with the progression of many types of cancer. Previous research from our laboratory aimed at identifying genes ... Read more
Overexpression of Kpnβ1 and Kpnα2 Importin Proteins in Cancer Derives from Deregulated E2F Activity

Author: van der Watt, Pauline J ; Ngarande, Ellen ; Leaner, Virna D Date: 2011 The Karyopherin superfamily comprises nuclear transport proteins, involved in the shuttling of certain cargo proteins into and out of the nucleus. Karyopherin β1 (Kpnβ1) and Karyopherin α2 (Kpnα2) are importin proteins, which work in concert ... Read more c b
p21-activated kinase 3 (PAK3) is an AP-1 regulated gene contributing to actin organisation and migration of transformed fibroblasts

Author: Holderness-Parker, Nina ; Donninger, Howard ; Birrer, Michael J ; Leaner, Virna D Date: 2013 Activating Protein 1 (AP-1) plays a vital role in cell proliferation, differentiation and apoptosis. While de-regulation of AP-1 has been linked to many cancers, little is known regarding its downstream transcriptional targets that associate ... Read more c b
Phosphoglucomutase 1 (PGM1) expression and regulation in cancer cells

Author: Maranyane, Hapiloe 'Mabaruti Date: 2015 Cancer cells undergo metabolism that is significantly different to normal cells, with an increased dependence on glucose metabolism as a hallmark of most cancers. Changes in global gene expression patterns are the major driving forces behind ... Read more