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Browsing by Author "Lacerda, Miguel"

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9β Polymorphism of the Glucocorticoid Receptor Gene Appears to Have Limited Impact in Patients with Addison’s Disease

Author: Ross, Ian Louis ; Dandara, Collet ; Swart, Marelize ; Lacerda, Miguel ; Schatz, Desmond ; Blom, Dirk Jacobus Date: 2014 BACKGROUND: Addison’s disease (AD) has been associated with an increased risk of cardiovascular disease. Glucocorticoid receptor polymorphisms that alter glucocorticoid sensitivity may influence metabolic and cardiovascular risk factors in ... Read more c b
Anti-retroviral therapy increases the prevalence of dyslipidemia in South African HIV-infected patients

Author: Dave, Joel A ; Levitt, Naomi S ; Ross, Ian L ; Lacerda, Miguel ; Maartens, Gary ; Blom, Dirk Date: 2016 Purpose Data on the prevalence of dyslipidaemia and associated risk factors in HIV-infected patients from sub-Saharan Africa is sparse. We performed a cross-sectional analysis in a cohort of HIV-infected South African adults. METHODS: We ... Read more c b
Collaborative Genre Tagging

Author: Leslie, James Date: 2020 Recommender systems (RS) are used extensively in online retail and on media streaming platforms to help users filter the plethora of options at their disposal. Their goal is to provide users with suggestions of products or artworks that they ... Read more
Fine-scale drivers of African Penguin prey dynamics in Algoa Bay, South Africa, and their impacts on penguin foraging ecology

Author: Mcinnes, Alistair McIntyre Date: 2016 African Penguins (Spheniscus demersus) have undergone a dramatic decrease in their population since the turn of this century prompting the up-grading of their conservation status to 'endangered'. There is growing evidence that variation in ... Read more
Identification of broadly neutralizing antibody epitopes in the HIV-1 envelope glycoprotein using evolutionary models

Author: Lacerda, Miguel ; Moore, Penny ; Ngandu, Nobubelo ; Seaman, Michael ; Gray, Elin ; Murrell, Ben ; Krishnamoorthy, Mohan ; Nonyane, Molati ; Madiga, Maphuti ; Wibmer, Constantinos ; Sheward, Daniel ; Bailer, Robert ; Gao, Hongmei ; Greene, Kelli ; Karim, Salim S ; M Date: 2013 BACKGROUND:Identification of the epitopes targeted by antibodies that can neutralize diverse HIV-1 strains can provide important clues for the design of a preventative vaccine. METHODS: We have developed a computational approach that can ... Read more c b
Identifying predictors of evolutionary dispersion with phylogeographic generalised linear models

Author: Wolff-Piggott, Timothy Date: 2017 Discrete phylogeographic models enable the inference of the geographic history of biological organisms along phylogenetic trees. Frequently applied in the context of epidemiological modelling, phylogeographic generalised linear models were ... Read more
Recreational fish-finders - an inexpensive alternative to scientific echo-sounders for unravelling the links between marine top predators and their prey

Author: McInnes, Alistair M ; Khoosal, Arjun ; Murrell, Ben ; Merkle, Dagmar ; Lacerda, Miguel ; Nyengera, Reason ; Coetzee, Janet C ; Edwards, Loyd C ; Ryan, Peter G ; Rademan, Johan Date: 2015 Studies investigating how mobile marine predators respond to their prey are limited due to the challenging nature of the environment. While marine top predators are increasingly easy to study thanks to developments in bio-logging technology, ... Read more c b
Recurrent neural network language models in the context of under-resourced South African languages

Author: Scarcella, Alessandro Date: 2018 Over the past five years neural network models have been successful across a range of computational linguistic tasks. However, these triumphs have been concentrated in languages with significant resources such as large datasets. Thus, many ... Read more
A topic model based approach to inferring episodic directional selection in protein coding sequences

Author: Sadiq, Hassan Taiwo Date: 2015 Pathogens, such as HIV and influenza, evolve in response to the selective pressures of their host environments accumulating changes in their genomes that offer fitness benefits. This selective pressure is characterised by three properties: ... Read more