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Browsing by Author "Keyser, Alana"

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Association of human TLR1 and TLR6 deficiency with altered immune responses to BCG vaccination in South African infants

Author: Randhawa, April Kaur ; Shey, Muki S ; Keyser, Alana ; Peixoto, Blas ; Wells, Richard D ; de Kock, Marwou ; Lerumo, Lesedi ; Hughes, Jane ; Hussey, Gregory ; Hawkridge, Anthony ; Kaplan, Gilla ; Hanekom, Willem A ; Hawn, Thomas R Date: 2011 The development of effective immunoprophylaxis against tuberculosis (TB) remains a global priority, but is hampered by a partially protective Bacillus Calmette-Guérin (BCG) vaccine and an incomplete understanding of the mechanisms of immunity ... Read more c b
BCG-specific T cell proliferation and cytotoxic capacity in infants as risk of tuberculosis disease, following newborn BCG vaccination

Author: Keyser, Alana Date: 2014 BCG is the only vaccine against tuberculosis and has been used for over 90 years. BCG efficacy is variable, especially in countries with high TB prevalence, where over a million deaths due to tuberculosis, are still reported annually. New TB ... Read more
Human newborn bacille Calmette–Guérin vaccination and risk of tuberculosis disease: a case-control study

Author: Fletcher, Helen A ; Filali-Mouhim, Ali ; Nemes, Elisa ; Hawkridge, Anthony ; Keyser, Alana ; Njikan, Samuel ; Hatherill, Mark ; Scriba, Thomas J ; Abel, Brian ; Kagina, Benjamin M ; Veldsman, Ashley ; Agudelo, Nancy Marín ; Kaplan, Gilla ; Hussey, Gregory D ; Sekaly, Rafick-Pierre ; Hanekom, Willem A Date: 2016 : An incomplete understanding of the immunological mechanisms underlying protection against tuberculosis (TB) hampers the development of new vaccines against TB. We aimed to define host correlates of prospective risk of TB disease following ... Read more
Phenotypic analysis of peripheral B cell populations during Mycobacterium tuberculosis infection and disease

Author: du Plessis, Willem J ; Keyser, Alana ; Walzl, Gerhard ; Loxton, André G Date: 2016 Abstract Background Mycobacterium tuberculosis (Mtb) remains an unresolved threat resulting in great annual loss of life. The role of B cells during the protective immunity to Mtb is still unclear. B cells have been described as effector cells ... Read more
Transcriptional profiling of mycobacterial antigen-induced responses in infants vaccinated with BCG at birth

Author: Fletcher, Helen ; Keyser, Alana ; Bowmaker, Mark ; Sayles, Peter ; Kaplan, Gilla ; Hussey, Greg ; Hill, Adrian ; Hanekom, Willem Date: 2009 BACKGROUND:Novel tuberculosis (TB) vaccines recently tested in humans have been designed to boost immunity induced by the current vaccine, Mycobacterium bovis Bacille Calmette-Guerin (BCG). Because BCG vaccination is used extensively in ... Read more c b

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