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Browsing by Author "Keeton, Roanne"

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Investigating cytokine responses to different strains of Mycobacterium tuberculosis

Author: Booi, Zandile Date: 2021 Mycobacterium tuberculosis (Mtb), the causative agent of human tuberculosis (TB), is one of the world's most prevalent fatal pathogens, infecting one third of the global population. The highly specialised pathogen that infects humans today ... Read more
NK-, NKT-and CD8-derived IFNγ drives myeloid cell activation and erythrophagocytosis, resulting in Trypanosomosis-associated acute anemia

Author: Cnops, Jennifer ; Trez, Carl De ; Stijlemans, Benoit ; Keirsse, Jiri ; Kauffmann, Florence ; Barkhuizen, Mark ; Keeton, Roanne ; Boon, Louis ; Brombacher, Frank ; Magez, Stefan Date: 2015 African trypanosomes are the causative agents of Human African Trypanosomosis (HAT/Sleeping Sickness) and Animal African Trypanosomosis (AAT/Nagana). A common hallmark of African trypanosome infections is inflammation. In murine trypanosomosis, ... Read more c b
Reactivation of M. tuberculosis infection in trans-membrane tumour necrosis factor mice

Author: Dambuza, Ivy ; Keeton, Roanne ; Allie, Nasiema ; Hsu, Nai-Jen ; Randall, Philippa ; Sebesho, Boipelo ; Fick, Lizette ; Quesniaux, Valerie J F ; Jacobs, Muazzam Date: 2011 Of those individuals who are infected with M. tuberculosis , 90% do not develop active disease and represents a large reservoir of M. tuberculosis with the potential for reactivation of infection. Sustained TNF expression is required for ... Read more c b
The characterisation of dendritic cell, microglial, macrophage and T cell responses during mycobacterial infection of the central nervous system

Author: Kgoadi, Khanyisile Date: 2021 Background: Tuberculosis (TB) remains a global health challenge and a quarter of the global population is infected with latent TB. It is a single infection that causes most deaths and was the number one cause of death in South Africa in 2017. ... Read more
The impact of malaria on the immunogenicity and efficacy of mycobacterium bovis BCG vaccination against mycobacterium tuberculosis in mice

Author: Tangie, Emily Nchangnwie Date: 2022 Background Bacillus Calmette-Guerin (BCG) remains the only licensed vaccine for use against tuberculosis (TB), however, it is poorly efficacious against pulmonary TB in adults. The poor efficacy has been attributed in part to coinfections ... Read more
TNF-dependent regulation and activation of innate immune cells are essential for host protection against cerebral tuberculosis

Author: Francisco, Ngiambudulu ; Hsu, Nai-Jen ; Keeton, Roanne ; Randall, Philippa ; Sebesho, Boipelo ; Allie, Nasiema ; Govender, Dhirendra ; Quesniaux, Valerie ; Ryffel, Bernhard ; Kellaway, Lauriston ; Jacobs, Muazzam Date: 2015 BACKGROUND: Tuberculosis (TB) affects one third of the global population, and TB of the central nervous system (CNS-TB) is the most severe form of tuberculosis which often associates with high mortality. The pro-inflammatory cytokine tumour ... Read more c b

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Browsing by Author "Keeton, Roanne"

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