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Browsing by Author "Karim, Salim Abdool"

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Features of recently transmitted HIV-1 clade C viruses that impact antibody recognition: implications for active and passive immunization

Author: Rademeyer, Cecilia ; Korber, Bette ; Seaman, Michael S ; Giorgi, Elena E ; Thebus, Ruwayhida ; Robles, Alexander ; Sheward, Daniel J ; Wagh, Kshitij ; Garrity, Jetta ; Carey, Brittany R ; Gao, Hongmei ; Greene, Kelli M ; Tang, Haili ; Bandawe, Gama P ; Marais, Jinny C ; Diphoko, Thabo E ; Hraber, Peter ; Tumba, Nancy ; Moore, Penny L ; Gray, Glenda E ; Kublin, James ; McElrath, M Juliana ; Vermeulen, Marion ; Middelkoop, Keren ; Bekker, Linda-Gail ; Hoelscher, Michael ; Maboko, Leonard ; Makhema, Joseph ; Robb, Merlin L ; Karim, Salim Abdool ; Karim, Quarraisha Abdool ; Kim, Jerome H ; Hahn, Beatrice H ; Gao, Feng ; Swanstrom, Ronald ; Morris, Lynn ; Montefiori, David C ; Williamson, Carolyn Date: 2016 Author Summary: Vaccine and passive immunization prophylactic trials that rely on antibody-mediated protection are planned for HIV-1 clade C epidemic regions of southern Africa, which have amongst the highest HIV-1 incidences globally. This ... Read more c b
Modulation of female genital tract-derived dendritic cell migration and activation in response to inflammatory cytokines and toll-like receptor agonists

Author: Shey, Muki S ; Maharaj, Niren ; Archary, Derseree ; Ngcapu, Sinaye ; Garrett, Nigel ; Karim, Salim Abdool ; Passmore, Jo-Ann S Date: 2016 HIV transmission across the genital mucosa is a major mode of new HIV infections in women. The probability of infection may be influenced by several factors including recruitment and activation of HIV target cells, such as dendritic cells ... Read more c b
No evidence for selection of HIV-1 with enhanced Gag-Protease or Nef function among breakthrough infections in the CAPRISA 004 tenofovir microbicide trial

Author: Chopera, Denis R ; Mann, Jaclyn K ; Mwimanzi, Philip ; Omarjee, Saleha ; Kuang, Xiaomei T ; Ndabambi, Nonkululeko ; Goodier, Sarah ; Martin, Eric ; Naranbhai, Vivek ; Karim, Salim Abdool Date: 2013 BACKGROUND: Use of antiretroviral-based microbicides for HIV-1 prophylaxis could introduce a transmission barrier that inadvertently facilitates the selection of fitter viral variants among incident infections. To investigate this, we assessed ... Read more c b
Optimal combinations of broadly neutralizing antibodies for prevention and treatment of HIV-1 Clade C infection

Author: Wagh, Kshitij ; Bhattacharya, Tanmoy ; Williamson, Carolyn ; Robles, Alex ; Bayne, Madeleine ; Garrity, Jetta ; Rist, Michael ; Rademeyer, Cecilia ; Yoon, Hyejin ; Lapedes, Alan ; Gao, Hongmei ; Greene, Kelli ; Louder, Mark K ; Kong, Rui ; Karim, Salim Abdool ; Burton, Dennis R ; Barouch, Dan H ; Nussenzweig, Michel C ; Mascola, John R ; Morris, Lynn ; Montefiori, David C ; Korber, Bette ; Seaman, Michael S Date: 2016 Author Summary In recent years, a new generation of monoclonal antibodies has been isolated from HIV-1 infected individuals that exhibit broad and potent neutralizing activity when tested against diverse strains of virus. There is a high level ... Read more c b
Transmission of HIV-1 CTL escape variants provides HLA-mismatched recipients with a survival advantage

Author: Chopera, Denis R ; Woodman, Zenda ; Mlisana, Koleka ; Mlotshwa, Mandla ; Martin, Darren P ; Seoighe, Cathal ; Treurnicht, Florette ; Rosa, Debra Assis de ; Hide, Winston ; Karim, Salim Abdool Date: 2008 Author Summary Following infection with HIV, it is well established that a person's genetic makeup is a major determinant of how quickly they will progress to AIDS. Particularly important is the class I Human leukocyte antigen (HLA) gene that ... Read more c b

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Browsing by Author "Karim, Salim Abdool"

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