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Browsing by Author "Kaplan, Gilla"

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Association of human TLR1 and TLR6 deficiency with altered immune responses to BCG vaccination in South African infants

Author: Randhawa, April Kaur ; Shey, Muki S ; Keyser, Alana ; Peixoto, Blas ; Wells, Richard D ; de Kock, Marwou ; Lerumo, Lesedi ; Hughes, Jane ; Hussey, Gregory ; Hawkridge, Anthony ; Kaplan, Gilla ; Hanekom, Willem A ; Hawn, Thomas R Date: 2011 The development of effective immunoprophylaxis against tuberculosis (TB) remains a global priority, but is hampered by a partially protective Bacillus Calmette-Guérin (BCG) vaccine and an incomplete understanding of the mechanisms of immunity ... Read more c b
Cellular immunity of naïve and BCG vaccinated neonates

Author: Watkins, Marcia Linda Vivienne Date: 2010 Despite more than 95% vaccination coverage with Mycobacterium bovis Bacille Calmette-Guérin (BCG), tuberculosis (TB) remains epidemic in South Africa. The dichotomy that successful pregnancy is usually associated with a type 2 (Th2) cytokine ... Read more
Genetic variation in TLR genes in Ugandan and South African populations and comparison with HapMap data

Author: Baker, Allison R ; Qiu, Feiyou ; Randhawa, April Kaur ; Horne, David J ; Adams, Mark D ; Shey, Muki ; Barnholtz-Sloan, Jill ; Mayanja-Kizza, Harriet ; Kaplan, Gilla ; Hanekom, Willem A ; Boom, W Henry ; Hawn, Thomas R ; Stein, Catherine M Date: 2012 Genetic epidemiological studies of complex diseases often rely on data from the International HapMap Consortium for identification of single nucleotide polymorphisms (SNPs), particularly those that tag haplotypes. However, little is known ... Read more c b
Induction of ER stress in macrophages of tuberculosis granulomas

Author: Seimon, Tracie A ; Kim, Mi-Jeong ; Blumenthal, Antje ; Koo, Jovanka ; Ehrt, Sabine ; Wainwright, Helen ; Bekker, Linda-Gail ; Kaplan, Gilla ; Nathan, Carl ; Tabas, Ira Date: 2010 BACKGROUND: The endoplasmic reticulum (ER) stress pathway known as the Unfolded Protein Response (UPR) is an adaptive survival pathway that protects cells from the buildup of misfolded proteins, but under certain circumstances it can lead to ... Read more c b
Mycobacterial strain diversity : impact on the host immune response

Author: Post, Frank A Date: 2003 Bibliography: p. 169-207. Read more
Transcriptional profiling of mycobacterial antigen-induced responses in infants vaccinated with BCG at birth

Author: Fletcher, Helen ; Keyser, Alana ; Bowmaker, Mark ; Sayles, Peter ; Kaplan, Gilla ; Hussey, Greg ; Hill, Adrian ; Hanekom, Willem Date: 2009 BACKGROUND:Novel tuberculosis (TB) vaccines recently tested in humans have been designed to boost immunity induced by the current vaccine, Mycobacterium bovis Bacille Calmette-Guerin (BCG). Because BCG vaccination is used extensively in ... Read more c b
Translational research for tuberculosis elimination: priorities, challenges, and actions

Author: Lienhardt, Christian ; Lönnroth, Knut ; Menzies, Dick ; Balasegaram, Manica ; Chakaya, Jeremiah ; Cobelens, Frank ; Cohn, Jennifer ; Denkinger, Claudia M ; Evans, Thomas G ; Källenius, Gunilla ; Kaplan, Gilla ; Kumar, Ajay M V ; Matthiessen, Line ; Mgone, Charles S ; Mizrahi, Valerie ; Mukadi, Ya-diul ; Nguyen, Viet Nhung ; Nordström, Anders ; Sizemore, Christine F ; Spigelman, Melvin ; Squire, S Bertel ; Swaminathan, Soumya ; Helden, Paul D Van ; Zumla, Alimuddin ; Weyer, Karin ; Weil, Diana ; Raviglione, Mario Date: 2016 Christian Lienhardt and colleagues describe the research efforts needed to end the global tuberculosis epidemic by 2035. Read more c b

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Browsing by Author "Kaplan, Gilla"

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