OpenUCT Home
→
Browsing by Author

Browsing by Author "Jacobs, Muazzam"

Now showing items 1-15 of 15

Fatal Mycobacterium tuberculosis infection despite adaptive immune response in the absence of MyD88

Author: Fremond, Cecile M ; Yeremeev, Vladimir ; Nicolle, Delphine M ; Jacobs, Muazzam ; Quesniaux,Valerie F ; Ryffel, Bernhard Date: 2004 Toll-like receptors (TLRs) such as TLR2 and TLR4 have been implicated in host response to mycobacterial infection. Here, mice deficient in the TLR adaptor molecule myeloid differentiation factor 88 (MyD88) were infected with Mycobacterium ... Read more
Investigating transmembrane TNF and transmembrane p55TNFR mediated signaling in host immune function during Mycobacterium tuberculosis infection

Author: Dambuza, Ivy M Date: 2010 The importance of TNF-TNFR signaling in immunity against M. tuberculosis has been established. The aims of this study were to characterize the functions of membrane-bound TNF (Tm-TNF) and soluble TNF (solTNF) and to investigate the role of ... Read more
The investigation of indigenous South African medicinal plants for activity against Mycobacterium tuberculosis

Author: Mokgethi, Thabang Date: 2006 This study investigated four indigenous South African medicinal plants that are commonly used in traditional medicine for their bioactivity against Mycobacterium tuberculosis. Crude plant extracts were prepared and characterized using HPLC ... Read more
Investigation of neuron T cell interaction in central nervous system tuberculosis

Author: Choshi, Phuti Sophia Date: 2017 Tuberculosis of the central nervous system (CNS TB) is the severest form of tuberculosis. It is classified as extra-pulmonary tuberculosis due to dissemination of Mycobacterium tuberculosis (Mtb) bacilli from the lung to the brain. It affects ... Read more
Investigation of the efficacy of identified acetolactate synthase inhibitors, peptidyl cysteine protease inhibitors, thiolactomycins, and thiosemicarbazone compounds against Mycobacterium tuberculosis

Author: Sebesho, Biopelo Felicity Date: 2006 Tuberculosis remains an important public health problem worldwide. There has been increase in the development of drug resistance towards INH and RIF, two of the frontline antimycobacterial drugs currently used in therapeutic regimes. As an ... Read more
Membrane TNF confers protection to acute mycobacterial infection

Author: Fremond, Cecile ; Allie, Nasiema ; Dambuza, Ivy M ; Grivennikov, Sergei ; Yeremeev, Vladimir ; Quesniaux, Valerie ; Jacobs, Muazzam ; Ryffel, Bernhard Date: 2005 BACKGROUND:Tumour necrosis factor (TNF) is crucial for the control of mycobacterial infection as TNF deficient (KO) die rapidly of uncontrolled infection with necrotic pneumonia. Here we investigated the role of membrane TNF for host resistance ... Read more c b
Modelling neuroimmune interactions using organotypic slice cultures

Author: Mbobo, Buchule Date: 2017 Tuberculosis predominantly manifests in the form of a pulmonary infection, but may spread out into other parts of the body and is then referred to as extrapulmonary tuberculosis (EPTB). One form of EPTB is an infection of the central nervous ... Read more
Reactivation of M. tuberculosis infection in trans-membrane tumour necrosis factor mice

Author: Dambuza, Ivy ; Keeton, Roanne ; Allie, Nasiema ; Hsu, Nai-Jen ; Randall, Philippa ; Sebesho, Boipelo ; Fick, Lizette ; Quesniaux, Valerie J F ; Jacobs, Muazzam Date: 2011 Of those individuals who are infected with M. tuberculosis , 90% do not develop active disease and represents a large reservoir of M. tuberculosis with the potential for reactivation of infection. Sustained TNF expression is required for ... Read more c b
The role of cell type-specific tumour necrosis factor in protective immunity against neurotuberculosis

Author: Francisco, Ngiambudulu Mbandu Date: 2013 Neurotuberculosis is the most severe form of extra-pulmonary tuberculosis, characterised by the formation of rich foci a brain form of granulomas, and tuberculous meningitis. Granulomas contain mycobacteria by recruitment of immune cells that ... Read more
The role of IL-4 and IL-13 in pulmonary tuberculosis using gene-deficient mice and protective efficacy of the purine-deficient auxotroph of Mycobacterium tuberculosis

Author: Brown, Najmeeyah Date: 2002 Absence of the TH2 inducing cytokine IL-4 has been shown not to increase the TH1 response and resistance to mycobacterial infection. This study asked whether the combined absence of IL-4 and IL3, as compared to IL-4 deficiency only, would ... Read more
The role of TNFRp55 and TNFRp75 in the host immune response to Mycobacterium tuberculosis

Author: Keeton, Roanne Shay Date: 2009 Tumor necrosis factor alpha (TNFα) is critical for host protective immunity against Mycobacterium tuberculosis infection. TNFRp55 and TNFRp75 can both bind TNFα and conduct signaling, however the respective roles, in particular that ... Read more
The role of Tumour Necrosis Factor, Lymphotoxin alpha and Interleukin-10 in the host's protective immune response against mycobacterial infection

Author: Jacobs, Muazzam Date: 2002 Bibliography: leaves 174-198. Read more
The characterisation of dendritic cell, microglial, macrophage and T cell responses during mycobacterial infection of the central nervous system

Author: Kgoadi, Khanyisile Date: 2021 Background: Tuberculosis (TB) remains a global health challenge and a quarter of the global population is infected with latent TB. It is a single infection that causes most deaths and was the number one cause of death in South Africa in 2017. ... Read more
The impact of malaria on the immunogenicity and efficacy of mycobacterium bovis BCG vaccination against mycobacterium tuberculosis in mice

Author: Tangie, Emily Nchangnwie Date: 2022 Background Bacillus Calmette-Guerin (BCG) remains the only licensed vaccine for use against tuberculosis (TB), however, it is poorly efficacious against pulmonary TB in adults. The poor efficacy has been attributed in part to coinfections ... Read more
TNF-dependent regulation and activation of innate immune cells are essential for host protection against cerebral tuberculosis

Author: Francisco, Ngiambudulu ; Hsu, Nai-Jen ; Keeton, Roanne ; Randall, Philippa ; Sebesho, Boipelo ; Allie, Nasiema ; Govender, Dhirendra ; Quesniaux, Valerie ; Ryffel, Bernhard ; Kellaway, Lauriston ; Jacobs, Muazzam Date: 2015 BACKGROUND: Tuberculosis (TB) affects one third of the global population, and TB of the central nervous system (CNS-TB) is the most severe form of tuberculosis which often associates with high mortality. The pro-inflammatory cytokine tumour ... Read more c b

Now showing items 1-15 of 15

Browse

All of OpenUCT

Browsing by Author "Jacobs, Muazzam"

Browsing by Author "Jacobs, Muazzam"

Browse

All of OpenUCT