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Browsing by Author "Hoving, Jennifer C"

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Deletion of IL-4 receptor alpha on dendritic cells renders BALB/c mice hypersusceptible to Leishmania major infection

Author: Hurdayal, Ramona ; Nieuwenhuizen, Natalie E ; Revaz-Breton, Mélanie ; Smith, Liezel ; Hoving, Jennifer C ; Parihar, Suraj P ; Reizis, Boris ; Brombacher, Frank Date: 2013 In BALB/c mice, susceptibility to infection with the intracellular parasite Leishmania major is driven largely by the development of T helper 2 (Th2) responses and the production of interleukin (IL)-4 and IL-13, which share a common receptor ... Read more c b
IL-4Rα-associated antigen processing by B cells promotes immunity in Nippostrongylus brasiliensis infection

Author: Horsnell, William G C ; Darby, Matthew G ; Hoving, Jennifer C ; Nieuwenhuizen, Natalie ; McSorley, Henry J ; Ndlovu, Hlumani ; Bobat, Saeeda ; Kimberg, Matti ; Kirstein, Frank ; Cutler, Anthony J Date: 2013 In this study, B cell function in protective TH2 immunity against N. brasiliensis infection was investigated. Protection against secondary infection depended on IL-4Rα and IL-13; but not IL-4. Protection did not associate with parasite specific ... Read more c b
IL-4Rα-independent expression of mannose receptor and Ym1 by macrophages depends on their IL-10 responsiveness

Author: Dewals, Benjamin G ; Marillier, Reece G ; Hoving, Jennifer C ; Leeto, Mosiuoa ; Schwegmann, Anita ; Brombacher, Frank Date: 2010 IL-4Rα-dependent responses are essential for granuloma formation and host survival during acute schistosomiasis. Previously, we demonstrated that mice deficient for macrophage-specific IL-4Rα (LysMcreIl4ra−/lox) developed increased hepatotoxicity ... Read more c b

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Browsing by Author "Hoving, Jennifer C"

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