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Browsing by Author "Horsnell, William"

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Alterations in preconception, antenatal, and postnatal maternal gut microbiota influence offspring intestinal microbiota and immunity

Author: Nyangahu, Donald D Date: 2017 Maternal microbiota during pregnancy, as well as maternal disease state, may impact offspring gut bacterial colonisation. Here, we explore the impact of maternal antibiotics during gestation and/or nursing on offspring gut microbiota. Further, ... Read more
Bystander influence of nematode exposure on subsequent herpesvirus infections in vivo

Author: Chetty, Alisha Date: 2019 Parasitic worms have the ability to modulate the hosts immune response to promote host control of the infection and also parasite survival in the host. Helminth infections classically induce a potent Th2-biased and regulatory immune imprint. ... Read more
Disruption of maternal gut microbiota during gestation alters offspring microbiota and immunity

Author: Nyangahu, Donald D ; Lennard, Katie S ; Brown, Bryan P ; Darby, Matthew G ; Wendoh, Jerome M ; Havyarimana, Enock ; Smith, Peter ; Butcher, James ; Stintzi, Alain ; Mulder, Nicola ; Horsnell, William ; Jaspan, Heather B Date: 07 Jul 2018 Background: Early life microbiota is an important determinant of immune and metabolic development and may have lasting consequences. The maternal gut microbiota during pregnancy or breastfeeding is important for defining infant gut microbiota. ... Read more
Early-life immunity and susceptibility to Mycobacteria

Author: Logan, Erin Date: 2018 The naïve and not-yet developed infant immune system exhibits heightened susceptibility to external factors (e.g pathogens), and is shaped by these and others, such as maternal immunity. However, we do not yet fully understand their impact ... Read more
The function of IL-4Rα expression on key immune cells during experimental Nippostrongylus brasiliensis infections

Author: Mearns, Helen Date: 2006 The lifecycle of the parasitic nematode Nippostrogylus brasiliensis resembles that of the human hookworms Necator americanus and Ancylostoma duodenale and as such is a useful murine model for studying hookworm disease. Read more
IL-4/IL-13 independent goblet cell hyperplasia in experimental helminth infections

Author: Marillier, Reece ; Michels, Chesney ; Smith, Elizabeth ; Fick, Lizette ; Leeto, Mosiuoa ; Dewals, Benjamin ; Horsnell, William ; Brombacher, Frank Date: 2008 BACKGROUND: Intestinal mucus production by hyperplasic goblet cells is a striking pathological feature of many parasitic helminth infections and is related to intestinal protection and worm expulsion. Induction of goblet cell hyperplasia is ... Read more c b
Inducible deletion of CD28 prior to secondary nippostrongylus brasiliensis infection impairs worm expulsion and recall of protective memory CD4 (+) T cell responses

Author: Ndlovu, Hlumani ; Darby, Mathew ; Froelich, Monika ; Horsnell, William ; Lühder, Fred ; Hünig, Thomas ; Brombacher, Frank Date: 2014 IL-13 driven Th2 immunity is indispensable for host protection against infection with the gastrointestinal nematode Nippostronglus brasiliensis. Disruption of CD28 mediated costimulation impairs development of adequate Th2 immunity, showing ... Read more c b
The influence of maternal Nippostrongylus brasiliensis infection on immunity in offspring

Author: Mrdjen, Dunja Date: 2013 This study investigates imprinting of the murine fetal immune system by maternal infection with the helminth Nippostrongylus brasiliensis (Nb) prior to pregnancy and its effect on control of the Salmonella enterica serovar typhimurium (STm) ... Read more
Investigating the role of CD28 costimulation and IL-4/IL-13 responsive myeloid and lymphoid cells during helminth infections in mice

Author: Ndlovu, H Hlumani Date: 2013 The aim of this study was to evaluate the importance of CD28 in initiating protective Th2 immunity against both primary and secondary infections with N. brasiliensis. Our findings demonstrate that CD28 is required for initiation of protective ... Read more
Preconception maternal exposure to Nippostrongylus brasiliensis transfers protection against Nb to her offspring

Author: Darby, Matthew G Date: 2016 In early life the immature immune system has a reduced ability to control infection. This susceptibility is offset by transfer of protective immune components from the mother. Helminth infections are widespread and can have a long lasting ... Read more
Protective immunity against Nippostrongylus brasiliensis requires antigen presentation by IL-4Rα responsive B cells

Author: Darby, Matthew G Date: 2012 Nippostrongylus brasiliensis is a parasitic nematode infection that affects rodents. B-cells have been shown to play an important role in immunity to many different infections by antibody production and T-cell activation. But B-cell function ... Read more
Role of M3 muscarinic receptor in regulation of immunity to infectious pathogens

Author: Vira, Alykhan Date: 2013 During the last decade, cholinergic signaling via acetylcholine and its receptors has emerged as an important regulator of immunity. Acetylcholine binds to and signals through two types of receptors; nicotinic and muscarinic receptors. Studies ... Read more
Spatial and temporal regulation of IL4Rα expression

Author: Smith, Elizabeth M Date: 2008 In this study, we generated a new mouse model, which allows both inducible and cell-specific deletion and reconstitution of IL-IL4Rα expression. This model has the potential to add a new dimension to our understanding of IL4Rα biology. This ... Read more
The role of pulmonary innate and adaptive immune responses to helminth infection

Author: Thawer, Sumaiyya G Date: 2014 Immunity to nematode infections requires a host T helper 2 (Th2) response promoted by epithelial cell driven IL-33 induction of cytokine secretion of Interleukin (IL)-4, 5 and 13 by a range of immune cells including innate lymphoid cells type ... Read more
The role of pulmonary innate and adaptive immune responses to helminth infection

Author: Thawer, Sumaiyya G Date: 2014 Immunity to nematode infections requires a host T helper 2 (Th2) response promoted by epithelial cell driven IL-33 induction of cytokine secretion of Interleukin (IL)-4, 5 and 13 by a range of immune cells including innate lymphoid cells type ... Read more
The role of Surfacant Protein D in the control of human helminth infections

Author: Baker, Zoe Date: 2020 Lung produced surfactant protein D (SP-D) is essential for both homeostasis and as an innate immune opsonin. In the project presented here, we aimed to translate data recently published by our group, which demonstrated that SP-D contributes ... Read more
The role of surfaceant protein A in immunity to HPV16 pseudovirus infection

Author: Ujma, Sylvia Date: 2018 Infection by oncogenic human papillomavirus (HPV) is known to be the causative agent for the development of various anogenital cancers, including cervical cancer. Worldwide, the majority of cervical cancer cases occur in less developed regions, ... Read more