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Browsing by Author "Hoffman, Margaret"

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The allelic distribution of -308 Tumor Necrosis Factor-alpha gene polymorphism in South African women with cervical cancer and control women

Author: Govan, Vandana ; Constant, Debbie ; Hoffman, Margaret ; Williamson, Anna-Lise Date: 2006 BACKGROUND:Cervical cancer is due to infection with specific high-risk types of human papillomavirus (HPV). Although the incidence of genital HPV infection in various population groups is high, most of these regress without intervention. ... Read more c b
An assessment of the factors that influence the infant feeding practices of HIV-positive mothers in The Mothers' Programmes : a qualitative study

Author: Mackowski, Amy M Date: 2005 Many researchers consider breastfeeding as the best way to feed an infant, as it provides numerous benefits both physical and psychological for mother and child (Baumslag & Michels, 1995; Preble & Piwoz, 1998; Smith & Kuhn, 2000; World Health ... Read more
CCR2-V64I polymorphism is associated with increased risk of cervical cancer but not with HPV infection or pre-cancerous lesions in African women

Author: Chatterjee, Koushik ; Dandara, Collet ; Hoffman, Margaret ; Williamson, Anna-Lise Date: 2010 BACKGROUND: Cervical cancer, caused by specific oncogenic types of human papillomavirus (HPV), is the second most common cancer in women worldwide. A large number of young sexually active women get infected by HPV but only a small fraction ... Read more c b
Depot medroxyprogesterone acetate versus norethisterone oenanthate for long-acting progestogenic contraception : a systematic review

Author: Draper, Beverly Date: 2006 [Background] Two injectable progestogen-only contraceptives (IPCs) depot medroxyprogesterone acetate (DMPA) and norethisterone oenanthate (NET-EN) continue to be extensively used in some countries, forming a large proportion of the health ... Read more
Determinants of sexual activity and its relation to cervical cancer risk among South African Women

Author: Cooper, Diane ; Hoffman, Margaret ; Carrara, Henri ; Rosenberg, Lynn ; Kelly, Judy ; Stander, Ilse ; Denny, Lynnette ; Williamson, Anna-Lise ; Shapiro, Samuel Date: 2007 BACKGROUND:Invasive cervical cancer is the commonest cause of cancer morbidity and mortality in South African women. This study provides information on adult women's sexual activity and cervical cancer risk in South Africa. METHODS: The data ... Read more c b
Fas and FasL gene polymorphisms are not associated with cervical cancer but differ among Black and Mixed-ancestry South Africans

Author: Chatterjee, Koushik ; Engelmark, Malin ; Gyllensten, Ulf ; Dandara, Collet ; Merwe, Lize ; Galal, Ushma ; Hoffman, Margaret ; Williamson, Anna-Lise Date: 2009 BACKGROUND:Cervical cancer is one of the most important cancers in African women. Polymorphisms in the Fas (FasR) and Fas ligand (FasL) genes have been reported to be associated with cervical cancer in certain populations. This study investigated ... Read more c b
HIV and pre-neoplastic and neoplastic lesions of the cervix in South Africa: a case-control study

Author: Moodley, Jennifer ; Hoffman, Margaret ; Carrara, Henri ; Allan, Bruce ; Cooper, Diane ; Rosenberg, Lynn ; Denny, Lynette ; Shapiro, Samuel ; Williamson, Anna-Lise Date: 2006 BACKGROUND:Cervical cancer and infection with human immunodeficiency virus (HIV) are both major public health problems in South Africa. The aim of this study was to determine the risk of cervical pre-cancer and cancer among HIV positive women ... Read more c b
Human papillomavirus prevalence, viral load and pre-cancerous lesions of the cervix in women initiating highly active antiretroviral therapy in South Africa: a cross-sectional study

Author: Moodley, Jennifer ; Constant, Deborah ; Hoffman, Margaret ; Salimo, Anna ; Allan, Bruce ; Rybicki, Ed ; Hitzeroth, Inga ; Williamson, Anna Lise Date: 2009 BACKGROUND:Cervical cancer and infection with human immunodeficiency virus (HIV) are both important public health problems in South Africa (SA). The aim of this study was to determine the prevalence of cervical squamous intraepithelial lesions ... Read more c b
Papanicolaou smears and cervical inflammatory cytokine responses

Author: Passmore, Jo-Ann ; Morroni, Chelsea ; Shapiro, Samual ; Williamson, Anna-Lise ; Hoffman, Margaret Date: 2007 In a case-control study among 2064 South African women to investigate the risk of clinically invasive cancer of the cervix, we found a marked reduction in the risk of cervical cancer among women who gave a history of ever having undergone ... Read more c b
Prevention of cervical cancer in South Africa : opportunities and challenges

Author: Moodley, Jennifer Rose Date: 2011 This thesis examines the challenges to and opportunities for comprehensive (primary and secondary) prevention of cervical cancer in South Africa (SA), a middle-income country. Read more
The agreement between cervical abnormalities identified by cytology and detection of high-risk types of human papillomavirus

Author: Allan, Bruce R ; Marais, Dianne J ; Denny, Lynette ; Hoffman, Margaret ; Shapiro, Samuel ; Williamson, Anna-Lise Date: 2006 Objectives and design. Human papillomavirus (HPV) is causally associated with cervical cancer. Using the Digene Hybrid Capture 2 high-risk HPV test (HC2), we investigated the prevalence of high-risk HPV in cervical specimens, and compared ... Read more
Using quantitative ultrasound for epidemiological research : associations with risk factors for low bone mineral density in South African premenopausal women

Author: Constant, Deborah Date: 2008 Quantitative Ultrasound (QUS) measurement at the calcaneum is a convenient, cost effective and noninvasive method of determining bone strength well suited to community-based research in countries with limited resources. Although only moderately ... Read more

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