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Browsing by Author "Heckmann, Jeannine"

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Distal sensory polyneuropathy in HIV/TB co-infection : the role of vitamin B6 and N-acetyltransferase 2 genetic variation

Author: Centner, Chad Date: 2012 Both human immunodeficiency virus (HIV) infection and tuberculosis (TB) are complicated by a painful distal sensory polyneuropathy (DSP) that may be due to virus-related HIV-DSP, antiretroviral toxic neuropathy (ATN) or isoniazid-induced ... Read more
Distal sensory polyneuropathy in South Africans infected with human immunodeficiency virus : a cross-sectional analysis of a community cohort

Author: Maritz, Jean Date: 2009 Introduction: Distal sensory polyneuropathy (DSP), the most common neurological complication of HIV infection, is related to either HIV or antiretroviral therapy (ART). Dideoxynucleoside reverse transcriptase inhibitors such as stavudine are ... Read more
Identifying the molecular basis for treatment resistance in a subset of myasthenia gravis patients of African ancestory

Author: Auret, Jennifer Mary Date: 2013 Myasthenia gravis (MG) is an autoimmune disease in which pathogenic antibodies block, target or destroy the acetylcholine receptors of the muscle endplate resulting in failure of neuromuscular transmission and fatigable weakness. We have ... Read more
Molecular analysis of decay accelerating factor as a potential susceptibility factor to developing treatment resistant extraocular muscle involvement in Myasthenia Gravis

Author: Uwimpuhwe, Henriette Date: 2009 Myasthenia gravis (MG) is an autoimmune disorder in which auto-antibodies directed at the acetylcholine receptors (AChR) of the neuromuscular junction (NMJ) block, alter or destroy their targets. The anti-AChR antibodies cause activation of ... Read more
Molecular characterisation of virus in the brains of patients with measles inclusion body encephalitis (MIBE)

Author: Hardie, Diana ; Albertyn, Christine ; Heckmann, Jeannine ; Smuts, Heidi Date: 2013 BACKGROUND: During 2009/10 a major measles epidemic caused by genotype B3 occurred in South Africa. Measles inclusion body encephalitis (MIBE) was diagnosed in a number of highly immuno-compromised HIV patients. The diagnosis was based on ... Read more c b
Neuropsychiatric symptoms in thymoma-associated and non-thymoma myasthenia gravis

Author: Freeman, Carla Patricia Date: 2012 Myasthenia gravis (MG) is an acetylcholine receptor antibody- mediated disease targeting the neuromuscular junction resulting in fatigable muscle weakness. A number of reports have suggested a high prevalence of psychiatric symptoms amongst ... Read more
Project title: The Morbidity associated with Painful Neuropathy in HIV-infected subjects Anti-Retroviral Therapies: An assessment of self-management stratergies

Author: Ismail, Dr M Date: 2010 Objective: To establish the frequency of anti-retroviral treatment (ART)-related distal sensory polyneuropathy in a community-based clinic. To identify the self-management strategies these subjects are using to cope with their pain, and the ... Read more
A single-blinded trial of methotrexate versus azathioprine as steroid-sparing agents in generalized myasthenia gravis

Author: Heckmann, Jeannine ; Rawoot, Amanullah ; Bateman, Kathleen ; Renison, Rudi ; Badri, Motasim Date: 2011 BACKGROUND:Long-term immunosuppression is often required in myasthenia gravis (MG). There are no published trials using methotrexate (MTX) in MG. The steroid-sparing efficacy of azathioprine (AZA) has been demonstrated after 18-months of ... Read more c b
Subacute measles encephalitis: The neurological sequelae of the measles outbreak in South Africa

Author: Albertyn, Christine Herculine Date: 2014 A measles outbreak occurred in South Africa between 2009 and 2011 with 18 699 confirmed cases. This highly contagious virus can affect the central nervous system in many ways. Early in the disease course there may be direct viral involvement ... Read more