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Browsing by Author "Hatherill, Mark"

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The candidate TB vaccine, MVA85A, induces highly durable Th1 responses

Author: Tameris, Michele ; Geldenhuys, Hennie ; Luabeya, Angelique KanyKany ; Smit, Erica ; Hughes, Jane E ; Vermaak, Samantha ; Hanekom, Willem A ; Hatherill, Mark ; Mahomed, Hassan ; McShane, Helen ; Scriba,Thomas J Date: 2014 BACKGROUND: Vaccination against tuberculosis (TB) should provide long-term protective immunity against Mycobacterium tuberculosis ( M.tb ). The current TB vaccine, Bacille Calmette-Guerin (BCG), protects against disseminated childhood TB, but ... Read more c b
Comparison of mantoux and tine tuberculin skin tests in BCG-vaccinated children investigated for tuberculosis

Author: Pan, Wenli ; Matizirofa, Lyness ; Workman, Lesley ; Hawkridge, Tony ; Hanekom, Willem ; Mahomed, Hassan ; Hussey, Gregory ; Hatherill, Mark Date: 2009 Background: Tuberculin skin tests (TSTs) are long-established screening methods for tuberculosis (TB). We aimed to compare agreement between the intradermal Mantoux and multipuncture percutaneous Tine methods and to quantify risk factors for ... Read more c b
Diagnosis and management of potentially infectious patients with suspected pulmonary tuberculosis in a developing country setting

Author: González-Angulo, Licé Yulieth Date: 2011 This thesis comprises two projects, which focus on simple TB control strategies that can help reduce the risk of M. tuberculosis transmission ... New effective and field-adapted interventions are needed to improve TB programme outcomes. Two ... Read more
Does helminth treatment reduce the risk of active tuberculosis in a cohort of children from high tuberculosis risk population who have been vaccinated with BCG at birth?

Author: Workman, Lesley Date: 2009 [Background] Research in adults and older children has shown an association between Mycobacterium tuberculosis and helminth infection, with those infected with helminths at greater risk of tuberculosis. This association is believed to be on ... Read more
Early-life immunity and susceptibility to Mycobacteria

Author: Logan, Erin Date: 2018 The naïve and not-yet developed infant immune system exhibits heightened susceptibility to external factors (e.g pathogens), and is shaped by these and others, such as maternal immunity. However, we do not yet fully understand their impact ... Read more
Evaluation of the utility of specific CXR features for diagnosis of pulmonary tuberculosis in young children using multiple readers

Author: Ho-Yee, Ruschka Date: 2015 INTRODUCTION: The diagnosis of childhood pulmonary tuberculosis (TB) can be notoriously difficult. The chest X-ray (CXR) is a significant diagnostic resource in the detection of PTB in children. However, non-specific radiological features ... Read more
Isolation of Non-Tuberculous Mycobacteria in Children Investigated for Pulmonary Tuberculosis

Author: Hatherill, Mark ; Hawkridge, Tony ; Whitelaw, Andrew ; Tameris, Michele ; Mahomed, Hassan ; Moyo, Sizulu ; Hanekom, Willem ; Hussey, Gregory Date: 2006 Objective To evaluate the frequency and clinical significance of non-tuberculous mycobacteria (NTM) isolates among children investigated for pulmonary tuberculosis in a rural South African community. METHODS: Children were investigated for ... Read more c b
Optimal tuberculosis case-finding methodologies for field trials of new tuberculosis vaccines in young children

Author: Moyo, Sizulu Date: 2013 There is paucity of evidence to guide case-finding strategies in field trials of new tuberculosis vaccines conducted in young children. To investigate case-finding and case detection methods for tuberculosis in tuberculosis field trials ... Read more
A quantitative analysis of complexity of human pathogen-specific CD4 T cell responses in healthy M. tuberculosis infected South Africans

Author: Arlehamn, Cecilia S Lindestam ; McKinney, Denise M ; Carpenter, Chelsea ; Paul, Sinu ; Rozot, Virginie ; Makgotlho, Edward ; Gregg, Yolande ; Van Rooyen, Michele ; Ernst, Joel D ; Hatherill, Mark ; Hanekom, Willem A ; Peters, Bjoern ; Scriba, Thomas J ; Sette, Alessandro Date: 2016 Author Summary: Human pathogen-specific immune responses are tremendously complex and the techniques to study them ever expanding. There is an urgent need for a quantitative analysis and better understanding of pathogen-specific immune ... Read more c b
The relationship between metabolic acidosis, lactate, the lactate:pyruvate ratio, and outcome, in children with post-operative cardiogenic and septic shock

Author: Hatherill, Mark Date: 2007 Measures of the severity of metabolic acidosis (base excess) and of the severity of the underlying acid-base derangements (levels of lactate, chloride, albumin, and strong ion gap) have been used to differentiate survivors from nonsurvivors ... Read more
TB incidence in an adolescent cohort in South Africa

Author: Mahomed, Hassan ; Ehrlich, Rodney ; Hawkridge, Tony ; Hatherill, Mark ; Geiter, Lawrence ; Kafaar, Fazlin ; Abrahams, Deborah Ann ; Mulenga, Humphrey ; Tameris, Michele ; Geldenhuys, Hennie Date: 2013 BACKGROUND: Tuberculosis (TB) is a major public health problem globally. Little is known about TB incidence in adolescents who are a proposed target group for new TB vaccines. We conducted a study to determine the TB incidence rates and risk ... Read more c b
The burden of Perinatal Tuberculosis in HIV-infected mothers and their infants

Author: Downing, Katrina Jo Date: 2018 South Africa is one of six countries worldwide that has the highest national burden of tuberculosis (TB) and the largest number of HIV-infected people in the world. HIV infection, Mycobacterium tuberculosis (M.tb) infection and TB disease is ... Read more
Transmission of tuberculosis in high school students in Worcester, South Africa

Author: Bunyasi, Erick Date: 2020 Introduction Although adolescents have the highest force of Mycobacterium tuberculosis infection1 and rapidly increasing burden of tuberculosis (TB) disease through 10–19 years of age,2 there are few studies on adolescent Mycobacterium ... Read more
Transport of critically ill children in a resource-limited setting

Author: Hatherill, Mark Date: 2001 Transportation of critically ill children by inexperienced personnel may be associated with increased risk of transfer-related adverse events and mortality. To audit paediatric intensive care unit (PICU) transfer activity and transfer-related ... Read more
The tuberculin skin test versus QuantiFERON TB Gold® in predicting tuberculosis disease in an adolescent cohort study in South Africa

Author: Mahomed, Hassan ; Hawkridge, Tony ; Verver, Suzanne ; Abrahams, Deborah ; Geiter, Lawrence ; Hatherill, Mark ; Ehrlich, Rodney ; Hanekom, Willem A ; Hussey, Gregory D Date: 2011 Setting This study was conducted in a high tuberculosis (TB) burden area in Worcester, South Africa, with a notified all TB incidence rate of 1,400/100,000. Main Objective To compare the predictive value of a baseline tuberculin skin test ... Read more c b

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Browsing by Author "Hatherill, Mark"

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