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Browsing by Author "Happel, Anna-Ursula"

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Evaluation of probiotic and vaginal Lactobacillus species for the treatment of bacterial vaginosis and promotion of vaginal health in South African women

Author: Happel, Anna-Ursula Date: 2018 Background: Bacterial vaginosis (BV) increases women's risk for adverse reproductive outcomes and acquisition of sexually transmitted infections (STIs), including HIV. The etiology of BV is still unclear, and it has been hypothesized that ... Read more
In Silico Characterisation of Putative Prophages in Lactobacillaceae Used in Probiotics for Vaginal Health

Author: Happel, Anna-Ursula ; Kullin, Brian R ; Gamieldien, Hoyam ; Jaspan, Heather B ; Varsani, Arvind ; Martin, Darren ; Passmore, Jo-Ann S ; Froissart, Rémy Date: 20 Jan 2022 While live biotherapeutics offer a promising approach to optimizing vaginal microbiota, the presence of functional prophages within introduced Lactobacillaceae strains could impact their safety and efficacy. We evaluated the presence of ... Read more c b
Presence and Persistence of Putative Lytic and Temperate Bacteriophages in Vaginal Metagenomes from South African Adolescents

Author: Happel, Anna-Ursula ; Balle, Christina ; Maust, Brandon S ; Konstantinus, Iyaloo N ; Gill, Katherine ; Bekker, Linda-Gail ; Froissart, Rémy ; Passmore, Jo-Ann ; Karaoz, Ulas ; Varsani, Arvind ; Jaspan, Heather Date: 23 Nov 2021 The interaction between gut bacterial and viral microbiota is thought to be important in human health. While fluctuations in female genital tract (FGT) bacterial microbiota similarly determine sexual health, little is known about the presence, ... Read more c b
Probiotics for vaginal health in South Africa: what is on retailers’ shelves?

Author: Happel, Anna-Ursula ; Jaumdally, Shameem Z ; Pidwell, Tanya ; Cornelius, Tracy ; Jaspan, Heather B ; Froissart, Remy ; Barnabas, Shaun L ; Passmore, Jo-Ann S Date: 19 Jan 2017 Background: Probiotics are widely used to improve gastrointestinal (GI) health, but they may also be useful to prevent or treat gynaecological disorders, including bacterial vaginosis (BV) and candidiasis. BV prevalence is high in South Africa ... Read more
Testing the regulatory framework in South Africa – a single-blind randomized pilot trial of commercial probiotic supplementation to standard therapy in women with bacterial vaginosis

Author: Happel, Anna-Ursula ; Singh, Ravesh ; Mitchev, Nireshni ; Mlisana, Koleka ; Jaspan, Heather B ; Barnabas, Shaun L ; Passmore, Jo-Ann S Date: 10 Jul 2020 Abstract Background Bacterial vaginosis (BV) increases HIV risk and adverse reproductive outcomes. Standard-of-care (SOC) for BV are antibiotics; however, cure rates are low. Probiotics for vaginal health may be useful in improving cure and ... Read more

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Browsing by Author "Happel, Anna-Ursula"

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