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Browsing by Author "Hapgood, Janet P"

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Crosstalk between steroid and GnRH receptors in regulating gene expression in the mouse LÇT2 gonadotrope cell line

Author: Hills, Diederik Date: 2011 In this study we focus on the interplay of adrenal and gonadal hormone feedback regulating target receptor mRNA and protein expression in a pituitary gonadoptrope cell line, and discuss how crosstalk signalling may contribute to differential ... Read more
Differential effects of combinations of anti-retrovirals and progestins on gene expression and HIV-1 replication in cells of the female genital tract

Author: Dlamini, Sigcinile Date: 2017 Young women in areas of high HIV risk are more vulnerable to new HIV infections compared to men. With the development of programmes using anti-retrovirals (ARVs) to prevent HIV infection, the concurrent use of hormonal contraception and ARVs ... Read more
Differential effects of progestogens on HIV-1 replication and host gene expression in primary PBMCs and cervical tissue explants

Author: Ray, Roslyn Michelle Date: 2015 The synthetic progestogens, medroxyprogesterone acetate (MPA) and norethisterone enanthate (NET-EN),are widely used in developing countries as injectable contraceptives, where disease burden is high.Levonorgestrel (LNG) is a common progestogen ... Read more
Genomic and Non-Genomic cross talk between the Gonadotropin- releasing hormone receptor and glucocorticoid receptor signalling pathways

Author: Kotitschke, Andrea Date: 2009 Read more
The glucocorticoid receptor plays a central role in mammalian reproduction and signal integration in pituitary gonadotropes

Author: Wehmeyer, Lance Date: 2015 Reciprocal modulation between the glucocorticoid receptor (GR) and gonadotropin-releasing hormone (GnRH) signalling pathways is a potential mechanism for integrating cellular responses to stress with reproductive function. This study investigated ... Read more
Impact of glucocorticoid receptor density on ligand-independent dimerization, cooperative ligand-binding and basal priming of transactivation: a cell culture model

Author: Robertson, Steven ; Rohwer, Johann M ; Hapgood, Janet P ; Louw, Ann Date: 2013 Glucocorticoid receptor (GR) levels vary between tissues and individuals and are altered by physiological and pharmacological effectors. However, the effects and implications of differences in GR concentration have not been fully elucidated. ... Read more c b
The injectable-only contraceptive medroxyprogesterone acetate, unlike norethisterone acetate and progesterone, regulates inflammatory genes in endocervical cells via the glucocorticoid receptor

Author: Govender, Yashini ; Avenant, Chanel ; Verhoog, Nicolette J D ; Ray, Roslyn M ; Grantham, Nicholas J ; Africander, Donita ; Hapgood, Janet P Date: 2014 Clinical studies suggest that the injectable contraceptive medroxyprogesterone acetate (MPA) increases susceptibility to infections such as HIV-1, unlike the injectable contraceptive norethisterone enanthate (NET-EN). We investigated the ... Read more c b
Investigating crosstalk in lipid rafts between the glucocorticoid receptor and gonadotropin-releasing hormone receptor signaling pathways in a gonadotrope cell line

Author: Wehmeyer, Lance Date: 2010 A recent study from the Hapgood laboratory demonstrated the presence of a novel crosstalk mechanism between the glucocorticoid receptor (GR) and gonadotropin-releasing hormone receptor (GnRHR), indicating an additional direct mechanism for ... Read more
Mechanisms of glucocorticoid pro-inflammatory effects on CCL20: crosstalk and synergy

Author: Nhundu, Tawanda Date: 2018 Glucocorticoids (GCs) are steroid hormones widely prescribed to treat inflammatory disorders and are regarded as anti-inflammatory molecules. GCs classically induce the expression of antiinflammatory genes, while repressing pro-inflammatory ... Read more
Modulation of GR transcriptional signalling by HIV-1 Vpr insights into regulation by progestins

Author: Grantham, N J Date: 2012 It has been 30 years since HIV was first discovered, yet the molecular mechanisms whereby the virus mediates its pathogenic effects have not yet been completely elucidated. The glucocorticoid receptor (GR) is a ligand-activated host transcription ... Read more
Modulation of the progesterone receptor by progestogens, antiretroviral drugs and the glucocorticoid receptor

Author: Enfield, Kim Date: 2021 Hormonal contraceptives (HCs) and hormonal replacement therapies (HRTs) are widely used globally by women. However, the relative activity of some of the progestogens used in HCs and HRT has not been determined via their target steroid receptor ... Read more
Molecular mechanism of action of the glucocorticoid receptor:Role of ligand-dependent receptor phosphorylation and half-life in determination of ligand-specific transcriptional activity. : Contents Pages

Author: Avenant, Chanel Date: 2009 Glucocorticoids mediate their effects by binding to the glucocorticoid receptor (GR), resulting in modulation of transcription of target genes via direct binding to DNA or tethering via proteinprotein interactions. A central question is what ... Read more
The progestin-only contraceptive medroxyprogesterone acetate, but not norethisterone acetate, enhances HIV-1 Vpr-mediated apoptosis in human CD4+ T cells through the glucocorticoid receptor

Author: Tomasicchio, Michele ; Avenant, Chanel ; Toit, Andrea Du ; Ray, Roslyn M ; Hapgood, Janet P Date: 2013 The glucocorticoid receptor (GR) regulates several physiological functions, including immune function and apoptosis. The HIV-1 virus accessory protein, viral protein R (Vpr), can modulate the transcriptional response of the GR. Glucocorticoids ... Read more c b
Purification and characterization of a poly(dG).poly(dC)-binding protein from Parenchinus angulosis

Author: Patterton, Danielle Date: 1992 A poly(dG).poly(dC)-binding protein (suGF1) had previously been identified in sea urchin (Parenchinus angulosis) embryonic nuclear extracts (J.P. Hapgood, personal communication). suGF1 may be involved in the regulation of early histone gene ... Read more
The role of steroidogenic factor-1 (SF-1) in gonadotropin-releasing hormone (GnRH) receptor gene regulation

Author: Pheiffer, Carmen P Date: 1998 Gonadotropin releasing hormone (GnRH) is a key reproductive hormone in vertebrates and exerts its effects via the GnRH receptor (GnRHR) to result in the synthesis and release of the gonadotropin hormones in the pituitary gonadotrope cells. ... Read more
Role of the glucocorticoid receptor and HIV-1 Vpr in inflammatory gene expression and HIV-1 LTR transcription in response to dexamethasone and progestogens

Author: Govender, Yashini Date: 2015 The relationship between progestin-only injectable contraception and risk of HIV-1 acquisition is controversial. Most clinical data suggests that the injectable contraceptive medroxyprogesterone acetate (MPA), unlike norethisterone enanthate ... Read more

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Browsing by Author "Hapgood, Janet P"

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