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Browsing by Author "Hanekom, Willem A"

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Association between BCG-induced immunity and risk of TB disease

Author: Kagina, Benjamin Mugo Date: 2011 We tested the hypothesis that a lower frequency and profile of specific T cells induced by BCG vaccination at birth is associated with subsequent risk of developing tuberculosis. Read more
Association of human TLR1 and TLR6 deficiency with altered immune responses to BCG vaccination in South African infants

Author: Randhawa, April Kaur ; Shey, Muki S ; Keyser, Alana ; Peixoto, Blas ; Wells, Richard D ; de Kock, Marwou ; Lerumo, Lesedi ; Hughes, Jane ; Hussey, Gregory ; Hawkridge, Anthony ; Kaplan, Gilla ; Hanekom, Willem A ; Hawn, Thomas R Date: 2011 The development of effective immunoprophylaxis against tuberculosis (TB) remains a global priority, but is hampered by a partially protective Bacillus Calmette-Guérin (BCG) vaccine and an incomplete understanding of the mechanisms of immunity ... Read more c b
BCG-specific T cell proliferation and cytotoxic capacity in infants as risk of tuberculosis disease, following newborn BCG vaccination

Author: Keyser, Alana Date: 2014 BCG is the only vaccine against tuberculosis and has been used for over 90 years. BCG efficacy is variable, especially in countries with high TB prevalence, where over a million deaths due to tuberculosis, are still reported annually. New TB ... Read more
The candidate TB vaccine, MVA85A, induces highly durable Th1 responses

Author: Tameris, Michele ; Geldenhuys, Hennie ; Luabeya, Angelique KanyKany ; Smit, Erica ; Hughes, Jane E ; Vermaak, Samantha ; Hanekom, Willem A ; Hatherill, Mark ; Mahomed, Hassan ; McShane, Helen ; Scriba,Thomas J Date: 2014 BACKGROUND: Vaccination against tuberculosis (TB) should provide long-term protective immunity against Mycobacterium tuberculosis ( M.tb ). The current TB vaccine, Bacille Calmette-Guerin (BCG), protects against disseminated childhood TB, but ... Read more c b
CD8+ T-cell interleukin-7 receptor alpha expression as a potential indicator of disease status in HIV-infected children

Author: Sharma, Tanvi S ; Hughes, Jane ; Murillo, Amarylis ; Riley, Joanne ; Soares, Andreia ; Little, Francesca ; Mitchell, Charles D ; Hanekom, Willem A Date: 2008 BACKGROUND: Initiation and modification of antiretroviral therapy in HIV-infected children depend on viral load and CD4+ T-cell count. However, these surrogates have limitations, and complementary immunological markers to assess therapeutic ... Read more c b
Changes in the BCG-Induced T cell response over the first year of life

Author: Soares, Andreia Date: 2011 Bacille Calmette-Guerin (BCG), the only currently available tuberculosis vaccine, is the most widely administered vaccine in the Expanded Programme on Immunisation (EPI). Despite this, many gaps in our knowledge of BCG-induced T cell responses ... Read more
Characterisation of the T cell responses induced by BCG in infants over the first year of life

Author: Kwong Chung, Cheong Kwet Choy Date: 2011 Mycobacterium bovis Bacille Calmette Guerin (BCG) is the only licensed tuberculosis (TB) vaccine. Despite the immunisation of 3 billion individuals with this vaccine, TB remains a major cause of mortality worldwide. Therefore, there is an ... Read more
Characterization of CD8 T cell responses in Mycobacterium Tuberculosis infection

Author: Moshi, Noell Dominika Date: 2011 The aim of this project was to compare the breadth and magnitude of CFP10 and ESAT6-specific CD8 T cell responses in individuals with latent Mycobacterium tuberculosis (MTB) infection (LTBI) and active TB disease, and further define MTB-specific ... Read more
A comparative analysis of polyfunctional T cells and secreted cytokines induced by Bacille Calmette-Guerin immunisation in children and adults

Author: Ritz, Nicole ; Strach, Madeleine ; Yau, Carmen ; Dutta, Binita ; Tebruegge, Marc ; Connell, Tom G ; Hanekom, Willem A ; Britton, Warwick J ; Robins-Browne, Roy ; Curtis, Nigel Date: 2012 BCG vaccine is one of the most commonly-administered vaccines worldwide. Studies suggest the protective efficacy of BCG against TB is better for children than for adults. One potential explanation is that BCG induces a better protective immune ... Read more c b
Comparison of immune responses induced by Bacillus calmette-Guerin when given at birth or at 6 weeks of age in Ugandan Infants

Author: Lutwama, Fredrick Date: 2014 In Uganda, infants delivered at a health care facility receive the tuberculosis vaccine Bacillus Calmette-Guerin (BCG) on the first day of life. Infants delivered at home receive BCG at their first health care facility visit at 6 weeks of ... Read more
Correlates of risk of TB disease in infants with differential response to BCG vaccination

Author: Njikan, Samuel Ayaba Date: 2014 Studying prospective immune correlates of risk of TB disease following BCG vaccination is an important first step towards determining correlates of protection against TB, which can be identified only in a placebo-controlled randomized controlled ... Read more
Determinants of innate immune responses to mycobacteria

Author: Shey, Muki Shehu Date: 2012 Innate cells such as macrophages, monocytes, myeloid dendritic cells and granulocytes recognise mycobacteria and initiate immune responses such as phagocytosis, cytokine production and expression of maturation markers. The type and magnitude ... Read more
Development of novel T cell assays and assessment of immune recognition to latency associated M.tuberculosis-specific antigens Rv2660 and Rv2659

Author: Govender, Lerisa Date: 2010 Nearly 130 years have elapsed since the discovery of Mycobacterium tuberculosis (M.tb), the causative agent of tuberculosis, yet today it is estimated that 1 in every 3 of the worldʼs population is infected with this pathogen. In South Africa ... Read more
The effect of birth weight and gestational age on BCG-induced immune responses in infants following BCG vaccination

Author: Dube, Frederick Date: 2010 Bacillus Calmette?Gu?rin (BCG), the only currently licensed tuberculosis (TB) vaccine, provides variable efficacy. Despite the use of BCG, TB remains a global health problem. BCG is administered at birth; however, more than 15% of infants are ... Read more
Evaluation of Xpert® MTB/RIF assay in induced sputum and gastric lavage samples from young children with suspected tuberculosis from the MVA85A TB vaccine trial

Author: Bunyasi, Erick Wekesa ; Tameris, Michele ; Geldenhuys, Hennie ; Schmidt, Bey-Marrie ; Luabeya, Angelique Kany Kany ; Mulenga, Humphrey ; Scriba, Thomas J ; Hanekom, Willem A ; Mahomed, Hassan ; McShane, Helen Date: 2015 Objective Diagnosis of childhood tuberculosis is limited by the paucibacillary respiratory samples obtained from young children with pulmonary disease. We aimed to compare accuracy of the Xpert ® MTB/RIF assay, an automated nucleic acid ... Read more c b
Genetic variation in TLR genes in Ugandan and South African populations and comparison with HapMap data

Author: Baker, Allison R ; Qiu, Feiyou ; Randhawa, April Kaur ; Horne, David J ; Adams, Mark D ; Shey, Muki ; Barnholtz-Sloan, Jill ; Mayanja-Kizza, Harriet ; Kaplan, Gilla ; Hanekom, Willem A ; Boom, W Henry ; Hawn, Thomas R ; Stein, Catherine M Date: 2012 Genetic epidemiological studies of complex diseases often rely on data from the International HapMap Consortium for identification of single nucleotide polymorphisms (SNPs), particularly those that tag haplotypes. However, little is known ... Read more c b
Human newborn bacille Calmette–Guérin vaccination and risk of tuberculosis disease: a case-control study

Author: Fletcher, Helen A ; Filali-Mouhim, Ali ; Nemes, Elisa ; Hawkridge, Anthony ; Keyser, Alana ; Njikan, Samuel ; Hatherill, Mark ; Scriba, Thomas J ; Abel, Brian ; Kagina, Benjamin M ; Veldsman, Ashley ; Agudelo, Nancy Marín ; Kaplan, Gilla ; Hussey, Gregory D ; Sekaly, Rafick-Pierre ; Hanekom, Willem A Date: 2016 : An incomplete understanding of the immunological mechanisms underlying protection against tuberculosis (TB) hampers the development of new vaccines against TB. We aimed to define host correlates of prospective risk of TB disease following ... Read more
Mycobacterium tuberculosis peptides presented by HLA-E molecules are targets for human CD8 T-cells with cytotoxic as well as regulatory activity

Author: Joosten, Simone A ; van Meijgaarden, Krista E ; van Weeren, Pascale C ; Kazi, Fatima ; Geluk, Annemieke ; Savage, Nigel D L ; Drijfhout, Jan W ; Flower, Darren R ; Hanekom, Willem A ; Klein, Michèl R Date: 2010 Tuberculosis (TB) is an escalating global health problem and improved vaccines against TB are urgently needed. HLA-E restricted responses may be of interest for vaccine development since HLA-E displays very limited polymorphism (only 2 coding ... Read more c b
Patients with tuberculosis disease have Mycobacterium tuberculosis-specific CD8 T cells with a pro-apoptotic phenotype and impaired proliferative capacity, which is not restored following treatment

Author: Day, Cheryl L ; Moshi, Noella D ; Abrahams, Deborah A ; Van Rooyen, Michele ; O'rie, Terrence ; De Kock, Marwou ; Hanekom, Willem A Date: 2014 CD8 T cells play a critical role in control of chronic viral infections; however, the role of these cells in containing persistent bacterial infections, such as those caused by Mycobacterium tuberculosis (Mtb), is less clear. We assessed the ... Read more c b
A quantitative analysis of complexity of human pathogen-specific CD4 T cell responses in healthy M. tuberculosis infected South Africans

Author: Arlehamn, Cecilia S Lindestam ; McKinney, Denise M ; Carpenter, Chelsea ; Paul, Sinu ; Rozot, Virginie ; Makgotlho, Edward ; Gregg, Yolande ; Van Rooyen, Michele ; Ernst, Joel D ; Hatherill, Mark ; Hanekom, Willem A ; Peters, Bjoern ; Scriba, Thomas J ; Sette, Alessandro Date: 2016 Author Summary: Human pathogen-specific immune responses are tremendously complex and the techniques to study them ever expanding. There is an urgent need for a quantitative analysis and better understanding of pathogen-specific immune ... Read more c b

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