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Browsing by Author "Hadebe, Sabelo"

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Characterisation of innate fungal recognition in the lung

Author: Faro-Trindade, Inês ; Willment, Janet A ; Kerrigan, Ann M ; Redelinghuys, Pierre ; Hadebe, Sabelo ; Reid, Delyth M ; Srinivasan, Naren ; Wainwright, Helen ; Lang, Dirk M ; Steele, Chad Date: 2012 The innate recognition of fungi by leukocytes is mediated by pattern recognition receptors (PRR), such as Dectin-1, and is thought to occur at the cell surface triggering intracellular signalling cascades which lead to the induction of ... Read more c b
Microbial ligand costimulation drives neutrophilic steroid-refractory asthma

Author: Hadebe, Sabelo ; Kirstein, Frank ; Fierens, Kaat ; Chen, Kong ; Drummond, Rebecca A ; Vautier, Simon ; Sajaniemi, Sara ; Murray, Graeme ; Williams, David L ; Redelinghuys, Pierre ; Reinhart, Todd A ; Junecko, Beth A Fallert ; Kolls, Jay K ; Lambrecht, Bart N ; Brombacher, Frank ; Brown, Gordon D Date: 2015 Asthma is a heterogeneous disease whose etiology is poorly understood but is likely to involve innate responses to inhaled microbial components that are found in allergens. The influence of these components on pulmonary inflammation has been ... Read more c b
The role of Interleukin-4 induced gene 1 (IL-4i1) in allergic asthma and atopic dermatitis

Author: Ngomti, Amkele Date: 2022 Allergies are described as an unnecessary immune response to non-harmful substances known as allergens. Both allergic asthma and atopic dermatitis (AD) are said to be induced by elevated levels of immunoglobulin E (IgE) and T helper 2 (Th2) ... Read more
β-Glucan exacerbates allergic airway responses to house dust mite allergen

Author: Hadebe, Sabelo ; Kirstein, Frank ; Fierens, Kaat ; Redelinghuys, Pierre ; Murray, Graeme I ; Williams, David L ; Lambrecht, Bart N ; Brombacher, Frank ; Brown, Gordon D Date: 2016 β-(1,3)-Glucan is present in mould cell walls and frequently detected in house dust mite (HDM) faeces. β-Glucan exposure is thought to be associated with pulmonary allergic inflammation in mouse and man, although the published data are ... Read more c b

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Browsing by Author "Hadebe, Sabelo"

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