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Browsing by Author "Gray, Glenda"

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Enrolling adolescents in HIV vaccine trials: reflections on legal complexities from South Africa

Author: Slack, Catherine ; Strode, Ann ; Fleischer, Theodore ; Gray, Glenda ; Ranchod, Chitra Date: 2007 BACKGROUND:South Africa is likely to be the first country in the world to host an adolescent HIV vaccine trial. Adolescents may be enrolled in late 2007. In the development and review of adolescent HIV vaccine trial protocols there are many ... Read more c b
Optimal uses of antiretrovirals for prevention in HIV-1 serodiscordant heterosexual couples in South Africa: a modelling study

Author: Hallett, Timothy B ; Baeten, Jared M ; Heffron, Renee ; Barnabas, Ruanne ; De Bruyn, Guy ; Cremin, Íde ; Delany, Sinead ; Garnett, Geoffrey P ; Gray, Glenda ; Johnson, Leigh Date: 2011 Hallett et al use a mathematical model to examine the long-term impact and cost-effectiveness of different pre-exposure prophylaxis (PrEP) strategies for HIV prevention in serodiscordant couples. Read more c b
A phase IIA randomized clinical trial of a multiclade HIV-1 DNA prime followed by a multiclade rAd5 HIV-1 vaccine boost in healthy adults (HVTN204)

Author: Churchyard, Gavin J ; Morgan, Cecilia ; Adams, Elizabeth ; Hural, John ; Graham, Barney S ; Moodie, Zoe ; Grove, Doug ; Gray, Glenda ; Bekker, Linda-Gail ; McElrath, M Juliana Date: 2011 BACKGROUND: The safety and immunogenicity of a vaccine regimen consisting of a 6-plasmid HIV-1 DNA prime (envA, envB, envC, gagB, polB, nefB) boosted by a recombinant adenovirus serotype-5 (rAd5) HIV-1 with matching inserts was evaluated in ... Read more c b
Predictors of HVTN 503 MRK-AD5 HIV-1 gag/pol/nef vaccine Induced immune responses

Author: Hopkins, Kathryn L ; Laher, Fatima ; Otwombe, Kennedy ; Churchyard, Gavin ; Bekker, Linda-Gail ; DeRosa, Stephen ; Nchabeleng, Maphoshane ; Mlisana, Koleka ; Kublin, James ; Gray, Glenda Date: 2014 BACKGROUND: Phambili, the Merck (MRK)-Adenovirus Type 5 (Ad5) HIV-1 gag/pol/nef subtype B vaccine study, conducted in South Africa, suspended enrollment and vaccination when companion study, Step, was found non-efficacious. Although the vaccine ... Read more c b
Sequential Immunization with gp140 boosts immune responses primed by modified vaccinia Ankara or DNA in HIV-uninfected South African participants

Author: Churchyard, Gavin ; Mlisana, Koleka ; Karuna, Shelly ; Williamson, Anna-Lise ; Williamson, Carolyn ; Morris, Lynn ; Tomaras, Georgia D ; De Rosa, Stephen C ; Gilbert, Peter B ; Gu, Niya ; Yu, Chenchen ; Mkhize, Nonhlanhla N ; Hermanus, Tandile ; Allen, Mary ; Pensiero, Michael ; Barnett, Susan W ; Gray, Glenda ; Bekker, Linda-Gail ; Montefiori, David C ; Kublin, James ; Corey, Lawrence Date: 2016 BACKGROUND: The safety and immunogenicity of SAAVI DNA-C2 (4 mg IM), SAAVI MVA-C (2.9 x 10 9 pfu IM) and Novartis V2-deleted subtype C gp140 (100 mcg) with MF59 adjuvant in various vaccination regimens was evaluated in HIV-uninfected adults ... Read more c b
Uptake of genital mucosal sampling in HVTN 097, a phase 1b HIV vaccine trial in South Africa

Author: Lazarus, Erica Maxine ; Otwombe, Kennedy ; Adonis, Tania ; Sebastian, Elaine ; Gray, Glenda ; Grunenberg, Nicole ; Roux, Surita ; Churchyard, Gavin ; Innes, Craig ; Laher, Fatima Date: 2014 Because sexual transmission of HIV occurs across mucosal membranes, understanding the immune responses of the genital mucosa to vaccines may contribute knowledge to finding an effective candidate HIV vaccine. We describe the uptake of rectal ... Read more c b

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Browsing by Author "Gray, Glenda"

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