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Browsing by Author "Gray, Clive M"

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CD4 and CD8 T-cell responses to acellular pertussis and rotavirus vaccination in breast-fed HIV exposed, uninfected infants

Author: Nundalall, Trishana Date: 2017 Introduction: Vaccination is one of the most efficient ways to prevent infectious diseases, however due to the naivety and regulation of immunity found in infants, induction of vaccine-mediated immunity is challenging. Respiratory and diarrheal ... Read more
Characterisation of mucosal tissue in the foreskin after voluntary medical male circumcision

Author: Harryparsad, Rushil Date: 2016 Background: Medical Male Circumcision (MMC) reduces the risk of HIV-1 acquisition by up to 60% as shown in a number of randomized controlled trials in Uganda, Kenya and South Africa. MMC has also been shown to reduce the prevalence of other ... Read more
The effect of HIV-exposure on immune responses to expanded programme on immunization vaccines and antigens

Author: Kidzeru, Elvis Banboye Date: 2013 Immunization against vaccine-preventable infections is essential to reducing childhood morbidity and mortality. The immaturity and tolerogenicity of the immune system of infants renders them susceptible to infectious diseases and makes induction ... Read more
Effect of standard tuberculosis treatment on plasma cytokine levels in patients with active pulmonary tuberculosis

Author: Riou, Catherine ; Peixoto, Blas Perez ; Roberts, Lindi ; Ronacher, Katharina ; Walzl, Gerhard ; Manca, Claudia ; Rustomjee, Roxana ; Mthiyane, Thuli ; Fallows, Dorothy ; Gray, Clive M Date: 2012 BACKGROUND: Sputum Mycobacterium tuberculosis (Mtb) culture is commonly used to assess response to antibiotic treatment in individuals with pulmonary tuberculosis (TB). Such techniques are constrained by the slow growth rate of Mtb, and more ... Read more c b
Establishing a cohort at high risk of HIV infection in South Africa: challenges and experiences of the CAPRISA 002 acute infection study

Author: van Loggerenberg, Francois ; Mlisana, Koleka ; Williamson, Carolyn ; Auld, Sara C ; Morris, Lynn ; Gray, Clive M ; Karim, Quarraisha Abdool ; Grobler, Anneke ; Barnabas, Nomampondo ; Iriogbe, Itua Date: 2008 Objectives To describe the baseline demographic data, clinical characteristics and HIV-incidence rates of a cohort at high risk for HIV infection in South Africa as well as the challenges experienced in establishing and maintaining the cohort. ... Read more c b
Is obesity a risk factor for vaccine non-responsiveness?

Author: Young, Katherine M ; Gray, Clive M ; Bekker, Linda-Gail Date: 2013 Understanding the link between vaccine immunogenicity and efficacy is currently a major focus in HIV research. Consequently, recent developments in the HIV-1 vaccine field have led to a closer look at immune responses to known efficacious ... Read more c b
A subset of circulating blood mycobacteria-specific CD4 T cells can predict the time to Mycobacterium tuberculosis sputum culture conversion

Author: Riou, Catherine ; Gray, Clive M ; Lugongolo, Masixole ; Gwala, Thabisile ; Kiravu, Agano ; Deniso, Pamela ; Stewart-Isherwood, Lynsey ; Omar, Shaheed Vally ; Grobusch, Martin P ; Coetzee, Gerrit Date: 2014 We investigated 18 HIV-negative patients with MDR-TB for M. tuberculosis (Mtb)- and PPD-specific CD4 T cell responses and followed them over 6 months of drug therapy. Twelve of these patients were sputum culture (SC) positive and six patients ... Read more c b

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Browsing by Author "Gray, Clive M"

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