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Browsing by Author "Govender, Ureshnie"

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The biochemical and molecular characterisation of respiratory mucins in TB

Author: Govender, Ureshnie Date: 2006 The role of the dominant respiratory mucins (MUC5AC and MUC5B) and MUC2 has been investigated in chronic airway diseases as it is the mucin glycoprotein that confers upon mucus its biological, rheological and physicochemical properties. Within ... Read more
Comparison of same day diagnostic tools including Gene Xpert and unstimulated IFN-γ for the evaluation of pleural tuberculosis: a prospective cohort study

Author: Meldau, Richard ; Peter, Jonny ; Theron, Grant ; Calligaro, Greg ; Allwood, Brian ; Symons, Greg ; Khalfey, Hoosain ; Ntombenhle, Gina ; Govender, Ureshnie ; Binder, Anke ; van Zyl-Smit, Richard ; Dheda, Keertan Date: 08 Apr 2014 Background: The accuracy of currently available same-day diagnostic tools (smear microscopy and conventional nucleic acid amplification tests) for pleural tuberculosis (TB) is sub-optimal. Newer technologies may offer improved detection. ... Read more c b
Correlation of mycobacterium tuberculosis specific and non-specific quantitative Th1 T-cell responses with bacillary load in a high burden setting

Author: Theron, Grant ; Peter, Jonny ; Lenders, Laura ; van Zyl-Smit, Richard ; Meldau, Richard ; Govender, Ureshnie ; Dheda, Keertan Date: 2012 BACKGROUND: Measures of bacillary load in patients with tuberculosis (TB) may be useful for predicting and monitoring response to treatment. The relationship between quantitative T-cell responses and mycobacterial load remains unclear. We ... Read more c b
Diagnostic accuracy of quantitative PCR (Xpert MTB/RIF) for tuberculous pericarditis compared to adenosine deaminase and unstimulated interferon-γ in a high burden setting: a prospective study

Author: Pandie, Shaheen ; Peter, Jonathan G ; Kerbelker, Zita S ; Meldau, Richard ; Theron, Grant ; Govender, Ureshnie ; Ntsekhe, Mpiko ; Dheda, Keertan ; Mayosi, Bongani M Date: 18 Jun 2014 Background: Tuberculous pericarditis (TBP) is associated with high morbidity and mortality, and is an important treatable cause of heart failure in developing countries. Tuberculous aetiology of pericarditis is difficult to diagnose promptly. ... Read more
The diagnostic accuracy of urine-based Xpert MTB/RIF in HIV-infected hospitalized patients who are smear-negative or sputum scarce

Author: Peter, Jonathan G ; Theron, Grant ; Muchinga, Tapuwa E ; Govender, Ureshnie ; Dheda, Keertan Date: 2012 BACKGROUND: Hospitals in sub-Saharan Africa are inundated with HIV-infected patients and tuberculosis (TB) is the commonest opportunistic infection in this sub-group. Up to one third of TB-HIV co-infected patients fail to produce a sputum ... Read more c b
Utility of novel diagnostic tests for tuberculosis using human urine

Author: Muchinga, Tapuwa Enwell Date: 2012 Two thirds of new TB cases in sub-Saharan Africa are HIV coinfected. HIV-TB co-infection increases the incidence of extra-pulmonary, sputum smear-negative and sputum-scarce TB. In these vulnerable patientgroups with high mortality rates, ... Read more

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Browsing by Author "Govender, Ureshnie"

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